Effect of polyphenols extracted from tamarind (Tamarindus indica L.) seed coat on pathophysiological changes and red blood cell glutathione peroxidase activity in heat-stressed broilers

Aengwanich, Worapol; Suttajit, Maitree

doi:10.1007/s00484-012-0540-z

Cited by 9 publications

(1 citation statement)

References 34 publications

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“…Tamarind seed gum (Xyloglucan) is a hemicellulose extracted from the seed of the tamarind tree, Tamarindus indica. It is a non-ionic, neutral, branched polysaccharide that consists of a cellulose-like backbone carrying xylose and galactoxylose, present in the primary cell walls of all vascular plants [ 10 ]. Xyloglucan is characterized by a structural similarity to mucin and it is able to exert a protective barrier effect on mucosal and skin surfaces which restores the integrity of mucosal cells, protecting them from damaging agents, such as microorganisms and allergens [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Efficacy of Xyloglucan, Pea Protein and Opuntia ficus-indica Extract in a Preclinical Model of Psoriasis

Filippone

Casili

Lanza

et al. 2023

IJMS

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Psoriasis is a chronic inflammatory skin disease characterized by epidermal gene abnormalities, epidermal barrier defects and inflammation. Corticosteroids are considered to be standard treatments, but often come with side effects and lose efficacy with long-term use. Alternative treatments targeting the epidermal barrier defect are needed to manage the disease. Film-forming substances such as xyloglucan, pea protein and Opuntia ficus-indica extract (XPO) have generated interest for their ability to restore skin barrier integrity and may pose an alternative approach to disease management. Thus, the aim of this two-part study was to evaluate the barrier-protective properties of a topical cream containing XPO on the membrane permeability of keratinocytes exposed to inflammatory conditions and compare its efficacy to dexamethasone (DXM) in an in vivo model of psoriasis-like dermatitis. XPO treatment significantly reduced S. aureus adhesion, subsequent skin invasion and restored epithelial barrier function in keratinocytes. Furthermore, the treatment restored the integrity of keratinocytes, reducing tissue damage. In mice with psoriasis-like dermatitis, XPO significantly reduced erythema, inflammatory markers and epidermal thickening with a superior efficacy to dexamethasone. Given the promising results, XPO may represent a novel steroid-sparing therapeutic for epidermal-related diseases such as psoriasis, thanks to its ability to preserve skin barrier function and integrity.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Efficacy of Xyloglucan, Pea Protein and Opuntia ficus-indica Extract in a Preclinical Model of Psoriasis

Filippone

Casili

Lanza

et al. 2023

IJMS

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Growth, immune, antioxidant, and bone responses of heat stress-exposed broilers fed diets supplemented with tomato pomace

2015

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A study was conducted to investigate the effects of supplementation of dried tomato pomace (DTP) on growth performance, relative weights of viscera, serum biological parameters, antioxidant status, immune response, and bone composition of broilers exposed to a high ambient temperature. A total of 352 one-day-old male broiler chickens were randomly divided into four groups consisting of four replicates with 22 birds each. One group was reared under the thermoneutral zone and fed a corn-soybean meal basal diet. The other three groups were subjected to a cyclic heat stress from 29 to 42 days of age (34 ± 1 °C, 55 % RH, 5 h/day). These birds were fed corn-soybean meal basal diet or the same diet supplemented with 3 % DTP (420 mg lycopene/kg diet) or 5 % (708 mg lycopene/kg diet) of DTP. Blood samples were collected on days 28 and 42, and the birds were slaughtered at the same times. Supplementation of 5 % of DTP increased body weight and production index and decreased feed conversion ratio during 1-28 days of age. On day 28, the broilers supplemented with 5 % DTP had lower serum triglycerides and higher high-density lipoprotein (HDL) cholesterol concentration than those on the other dietary treatments. The activities of glutathione peroxidase (GPx) and superoxide dismutase (SOD) were higher and the concentration of malondialdehyde (MDA) was lower in the broilers fed 5 % TP than those of the broilers fed other diets at 28 days of age. The effects of heat stress (HS) were impaired body weight, enhanced serum activities of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lipase, and MDA concentration while reducing the activities of GPx and SOD. Dried tomato pomace supplementation did not influence growth performance under HS but ameliorated the negative effects of HS on the serum enzyme activities, GPx activity, and lipid peroxidation. Heat stress did not change the relative weights of the lymphoid organs but reduced the total and IgG titers for secondary antibody response to sheep red blood cells and titer against Newcastle disease virus and increased the heterophil/lymphocyte ratio. The supplementation with 5 % of DTP completely alleviated the negative effects of HS on immune responses. The ash, Ca, and P contents of the tibia bone were decreased under HS. The ash and Ca contents of the tibia were not significantly different between thermoneutral and heat-stressed broilers supplemented with 5 % DTP. In conclusion, dietary supplementation of DTP, particularly 5 % DTP, to broiler diet attenuated the detrimental effects of HS on the activities of serum enzymes, oxidative status, immune response, and bone composition.

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Possible Modulatory Effect of Tamarind Seed Coat Extract on Fluoride-Induced Pulmonary Inflammation and Fibrosis in Rats

Ameeramja

Perumal

2018

Inflammation

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Fluorosis (fluoride toxicity) seems to be reduced by plant secondary metabolites. Tamarind seed coat extract (TSCE), a mixture of procyanidins and polyphenols, possesses numerous pharmacological activities. Regardless of its beneficial properties, the underlying molecular mechanism against chronic fluorosis in vivo is not known. Hence, the present study is aimed to investigate the efficacy of TSCE against fluoride (F)-induced pulmonary toxicity in rats. Female Wistar rats were randomly divided into four groups and treated with NaF (300 ppm in drinking water) and TSCE (100 mg/kg/bw by oral intubation) alone and in combination daily for 30 days. The results showed that F exposure-induced modifications in lung injury markers in both serum and BALF were restored by TSCE supplementation. Additionally, F-induced changes in oxidative stress (NOX4 and p38α MAPK), inflammation (NF-κB, COX-2, and HO-1), apoptosis (Hsp27, Hsp60, caspase3p20, and PARP1), and fibrosis (TGF-β1, psmad3, Col1αl, and hydroxyproline level) markers in the lungs were modulated by TSCE. Thus, TSCE offers protection against F-induced pulmonary inflammation and fibrosis in rats.

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Effect of polyphenols extracted from tamarind (Tamarindus indica L.) seed coat on pathophysiological changes and red blood cell glutathione peroxidase activity in heat-stressed broilers

Cited by 9 publications

References 34 publications

Evaluation of the Efficacy of Xyloglucan, Pea Protein and Opuntia ficus-indica Extract in a Preclinical Model of Psoriasis

Evaluation of the Efficacy of Xyloglucan, Pea Protein and Opuntia ficus-indica Extract in a Preclinical Model of Psoriasis

Growth, immune, antioxidant, and bone responses of heat stress-exposed broilers fed diets supplemented with tomato pomace

Possible Modulatory Effect of Tamarind Seed Coat Extract on Fluoride-Induced Pulmonary Inflammation and Fibrosis in Rats

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