Effect of Polypeptides on Cell Proliferation and Apoptosis during Aging

Abstract

Polypeptide complexes derived from the bronchi, blood vessels, muscles, kidneys, ovaries, testes, and retina stimulated the processes of cell renewal in organotypic cultures of the corresponding organs of young and old animals. A correlation between the intensity of regeneration and animal' age was revealed. The polypeptide complexes reduced the expression of apoptotic factors p53 and caspase 3 and increased the expression of proliferation protein Ki-67. These results provide the basis for further study of the polypeptide complexes as stimulators of regenerative processes in different tissues during ageing.

Ameliorative effect of urolithin A ond-gal-induced liver and kidney damage in aging miceviaits antioxidative, anti-inflammatory and antiapoptotic properties

“…However, the core molecule in apoptosis is cleaved caspase-3 (a cysteine protease), which is known to be mainly in charge of the execution of apoptosis. 10,37 It has commonly been believed that Bax acts downstream of cleaved caspase-3 activation, and thus, apoptosis is inhibited by the downregulation of cleaved caspase-3, which plays an irreplaceable role in apoptosis. 38 Our results showed that urolithin A intervention signicantly downregulated Bcl-2 and Bax protein expression and upregulated the expression of cleaved caspase-3.…”