Effect of polymethacrylic acid (PMAA) on tumour metastasis☆

Franchi, G; Garattini, S.; Kram, L. K. J.; Putten, L.M. van

doi:10.1016/0014-2964(73)90056-x

Cited by 6 publications

(1 citation statement)

References 7 publications

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“…The interaction of PMAA with proteins has already been studied in the early 1950s. 11 Further examples comprise the use of PMAA for the retardation of tumor metastasis 12 and biomaterials for the growth of artificial bone 13 and for controlled drug release 14 as well as bioinert multilayer thin films. 15 It is the stimulus-responsive swelling behavior that controls the function of weak polyelectrolytes in biological systems.…”

Section: Introductionmentioning

confidence: 99%

Interaction of Poly(methacrylic acid) Brushes with Metal Ions: Swelling Properties

2005

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The swelling behavior of poly(methacrylic acid) (PMAA) brushes in contact with aqueous solutions of sodium, silver, alkaline-earth metal, copper, and aluminum nitrate was studied by multiple angle null ellipsometry. Fundamentally different swelling behavior were found for the interaction of the polyacid brush with metal cations of increasing valency or when going from a main group to a transition metal ion at constant valency. The different cations were classified with respect to the nature of their interaction with the surface-attached poly(carboxylic acid), and the findings were compared to theoretical predictions as well as to experimental investigations of related systems, such as free polyacids in solution or polyacid gels interacting with different metal cations.

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Section: Introductionmentioning

confidence: 99%

Interaction of Poly(methacrylic acid) Brushes with Metal Ions: Swelling Properties

2005

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Chemical Agents from Occupational Sources

Kay

1977

Comprehensive Physiology

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Enhancement by drugs of metastatic lung nodule formation after intravenous tumour cell injection

Putten¹,

Kram²,

Dierendonck³

et al. 1975

Intl Journal of Cancer

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In studies on a model of induced pulmonary metastasis in mice a tumour host system was analysed which was not affected by immunogenicity of the tumour for the host; neither intensive immunosuppression nor immunization caused a significant change in the quantity of pulmonary metastatic nodules. In contrast the application of cytostatic drugs and of Corynebacterium parvum could modify the pulmonary resistance to the formation of tumour nodules by a factor greater than 100 in either direction. This finding confirms the observation of others that major modification of the resistance to metastatic tumour formation can occur independently of classical immunological mechanisms. Special attention is drawn to the fact that cyclophosphamide enhances the formation of metastatic nodules in this model by factors of 100 to more than 1,000 whereas other cytostatic drugs including the cyclophosphamide congeners iphosphamide and trophosphamide are active only factors between 2 and 12. The possible practical significance of these findings is discussed.

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Effect of polymethacrylic acid (PMAA) on tumour metastasis☆

Cited by 6 publications

References 7 publications

Interaction of Poly(methacrylic acid) Brushes with Metal Ions: Swelling Properties

Interaction of Poly(methacrylic acid) Brushes with Metal Ions: Swelling Properties

Chemical Agents from Occupational Sources

Enhancement by drugs of metastatic lung nodule formation after intravenous tumour cell injection

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