Effect of polymer molecular weight on the tumor targeting characteristics of self-assembled glycol chitosan nanoparticles

Park, Kyeongsoon; Kim, Jong Ho; Nam, Yun Sik; Lee, Seulki; Nam, Hae Yun; Kim, Kwangmeyung; Park, Jae Hyung; Kim, In San; Choi, Kuiwon; Kim, Sang Yoon; Kwon, Ick Chan

doi:10.1016/j.jconrel.2007.04.009

Cited by 238 publications

(152 citation statements)

References 24 publications

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“…35 Ethylene chitosan nanoparticles had a prolonged circulating time in the blood with a high tumor-cell selectivity. 36 Moreover, this kind of effect was more obvious in ethylene chitosan nanoparticles of large molecular weight. Doxorubicin-chitosan polymeric micelles had excellent drug-loading properties, were suitable for targeting the liver and spleen, and significantly reduced drug toxicity to the heart and kidney.…”

Section: Targeting Of Chitosan Nanoparticlesmentioning

confidence: 99%

Recent advances of chitosan nanoparticles as drug carriers

Zeng¹

2011

IJN

248

123

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Chitosan nanoparticles are good drug carriers because of their good biocompatibility and biodegradability, and can be readily modified. As a new drug delivery system, they have attracted increasing attention for their wide applications in, for example, loading protein drugs, gene drugs, and anticancer chemical drugs, and via various routes of administration including oral, nasal, intravenous, and ocular. This paper reviews published research on chitosan nanoparticles, including its preparation methods, characteristics, modification, in vivo metabolic processes, and applications.

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Section: Targeting Of Chitosan Nanoparticlesmentioning

confidence: 99%

Recent advances of chitosan nanoparticles as drug carriers

Zeng¹

2011

IJN

248

123

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“…A 670 nm pulsed laser diode was used to excite Cy5.5 ® molecules. NIR fluorescence emission at 700 nm was collected and detected with a fast photo multiplier tube (Hamamatsu, Japan) and a time-correlated single photon counting system (Becker and HicklGmbH, Berlin, Germany) [30].…”

Section: Nir Fluorescence Real-time Tumor Imagingmentioning

confidence: 99%

“…The tumor targeting ability of the PHSM pop-upTAT was also demonstrated using a near-infrared (NIR) fluorescence imaging system [30]. The NIR fluorescence signals were monitored at scheduled time points after intravenous injection of polymeric micelles in human epidermoid KB tumor-bearing female nude mice (Fig.…”

Section: In Vivo Tumor Imagingmentioning

confidence: 99%

Super pH-sensitive multifunctional polymeric micelle for tumor pHe specific TAT exposure and multidrug resistance

Lee

Gao

Kim

et al. 2008

Journal of Controlled Release

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368

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As an alternative to cell specific cancer targeting strategies (which are often afflicted with the heterogeneity of cancer cells as with most biological systems), a novel polymeric micelle constitute of two block copolymers of poly(L-lactic acid)-b-poly(ethylene glycol)-b-poly(L-histidine)-TAT (transactivator of transcription) and poly(L-histidine)-b-poly(ethylene glycol) was developed. The micelle formed via the dialysis method was approximately 95 nm in diameter and contained 15 wt. % of doxorubicin (DOX) by weight. The micelle surface hides TAT during circulation, which has the strong capability to translocate the micelle into cells, and exposes TAT at a slightly acidic tumor extracellular pH to facilitate the internalization process. The micelle core was engineered for disintegration in early endosomal pH of tumor cells, quickly releasing DOX. The ionization process of the block copolymers and ionized polymers assisted in disrupting the endosomal membrane. This processes permitted high DOX concentrations in the cytosol and its target site of the nucleus, thus increasing DOX potency in various wild and multidrug resistant (MDR) cell lines (3.8-8.8 times lower IC 50 than free DOX, depending on cell line). When tested with the xenografted tumors of human ovarian tumor drug-resistant A2780/AD, human breast tumor drug-sensitive MCF-7, human lung tumor A549 and human epidermoid tumor KB in a nude mice model, all tumors significantly regressed in size by three bolus injections at a dose of DOX 10 mg equivalent/kg body per injection of DOX-loaded micelle at three day interval, while minimum weight loss was observed. This approach may replace the need for cell-specific antibodies or targeting ligands, thereby providing a general strategy for solid tumor targeting.

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“…Como um heteropolímero, a quitosana pode variar quanto à proporção das diferentes unidades monoméricas, geralmente expressa pelo grau de acetilação (percentual molar de grupos acetilados), quanto ao seu peso molecular, também expresso em termos de graus de polimerização e quanto ao padrão de polimerização. Parâmetros como solubilidade, 74 [79][80][81] Uma das principais aplicações da quitosana na nanotecnologia é a formação de nanopartículas por geleificação iônica. 82 Para tanto, o polímero é misturado com agentes reticulantes iônicos (geralmente sais com alta densidade eletrônica como tripolifosfato ou sulfato de sódio), havendo uma transição sol-gel do polímero, conjuntamente com uma nanoprecipitação controlada.…”

Section: Polímeros Catiônicos Quitosanaunclassified