Effect of polymer degradation on prolonged release of paclitaxel from filomicelles of polylactide/poly(ethylene glycol) block copolymers

J of Applied Polymer Sci

Liu

et al. 2017

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Section: Resultssupporting

confidence: 93%

Self‐assembled micelles prepared from poly(ɛ‐caprolactone)–poly(ethylene glycol) and poly(ɛ‐caprolactone/glycolide)–poly(ethylene glycol) block copolymers for sustained drug delivery

J of Applied Polymer Sci

Liu

et al. 2017

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“…This indicates that higher PGA content in the copolymers leads to faster paclitaxel release. In fact, faster degradation of micelles leads to faster drug release . With the increase of PGA component, the disruption of the chain structure and chain cleavage would be enhanced as in the case of PLGA copolymers, thus improving the drug release rate.…”

Section: Resultsmentioning

confidence: 99%

Drug release and biocompatibility of self‐assembled micelles prepared from poly (ɛ‐caprolactone/glycolide)‐poly (ethylene glycol) block copolymers

Polymers for Advanced Techs

et al. 2018

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A series of poly(ɛ‐caprolactone/glycolide)‐poly(ethylene glycol) (P(CL/GA)‐PEG) diblock copolymers were prepared by ring opening polymerization of a mixture of ɛ‐caprolactone and glycolide using mPEG as macro‐initiator and stannous octoate as catalyst. Self‐assembled micelles were prepared from the copolymers using nanoprecipitation method. The micelles were spherical in shape. The micelle size was larger for copolymers with longer PEG blocks. In contrast, the critical micelle concentration of copolymers increased with decreasing the overall hydrophobic block length. Drug loading and drug release studies were performed under in vitro conditions, using paclitaxel as a hydrophobic model drug. Higher drug loading was obtained for micelles with longer poly(ε‐caprolactone) blocks. Faster drug release was obtained for micelles of mPEG2000 initiated copolymers than those of mPEG5000 initiated ones. Higher GA content in the copolymers led to faster drug release. Moreover, drug release rate was enhanced in the presence of lipase from Pseudomonas sp., indicating that drug release is facilitated by copolymer degradation. The biocompatibility of copolymers was evaluated from hemolysis, dynamic clotting time, and plasma recalcification time tests, as well as MTT assay and agar diffusion test. Data showed that copolymer micelles present outstanding hemocompatibility and cytocompatibility, thus suggesting that P(CL/GA)‐PEG micelles are promising for prolonged release of hydrophobic drugs.

“…The architecture of self‐assembled aggregates mainly depends on the hydrophilic/hydrophobic balance of the copolymers. Recently, Jelonek et al reported on the self‐assembly and drug release properties of a series of poly( L ‐lactide)‐poly(ethylene glycol) (PLLA‐PEG) diblock copolymers . Filomicelles were obtained from copolymers with relatively long PLLA blocks.…”

Section: Introductionmentioning

confidence: 99%

“…Filomicelles were obtained from copolymers with relatively long PLLA blocks. The in vitro release of paclitaxel from PLLA‐PEG filomicelles was very slow and mainly dependent on the degradation of PLLA blocks …”

Section: Introductionmentioning

confidence: 99%

“…Recently, Jelonek et al reported on the self-assembly and drug release properties of a series of poly(L-lactide)-poly(ethylene glycol) (PLLA-PEG) diblock copolymers. 5,6 Filomicelles were obtained from copolymers with relatively long PLLA blocks. The in vitro release of paclitaxel from PLLA-PEG filomicelles was very slow and mainly dependent on the degradation of PLLA blocks.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Biocompatibility evaluation of self‐assembled micelles prepared from poly(lactide‐co‐glycolide)‐poly(ethylene glycol) diblock copolymers

Shen

Polymers for Advanced Techs

et al. 2017

Self Cite

In this work, a series of PLGA-PEG diblock copolymers were synthesized by ring-opening polymerization of L-lactide and glycolide using mPEG as macroinitiator and stannous octoate as catalyst. Spherical micelles were obtained from the various copolymers by using co-solvent evaporation method. The biocompatibility of micelles was evaluated with the aim of assessing their potential in the development of drug delivery systems. Various aspects of biocompatibility were considered, including MTT assay, agar diffusion test, release of cytokines, hemolytic test, dynamic clotting time, protein adsorption in vitro, and zebrafish embryonic compatibility in vivo.The combined results revealed that the micelles present good cytocompatibility and hemocompatibility in vitro. Moreover, the cumulative effects of micelles throughout embryos developing stages have no toxicity in vivo. It is thus concluded that micelles prepared from PLGA-PEG copolymers present good biocompatibility as potential drug carrier.