Abstract:Currently, many central nervous system disorders cannot be treated effectively using conventional drug delivery methods such as oral and intravenous drug administration. Therapeutic agents for such disorders often contain polar proteins with high molecular weight compounds (i.e. enzymes, antibodies and gene vectors) that are too large to diffuse through the tight junctions of the blood brain barrier (BBB) [1]. Moreover, it has been shown that low molecular weight compounds, though highly diffusive within brain… Show more
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