Effect of polymer binder on surface texturing by photoembossing

Hughes-Brittain, NF; Picot, OT Olivier; Dai, Mian; Peijs, Ton; Bastiaansen, Cwm Cees

doi:10.1016/j.apsusc.2012.05.059

Cited by 7 publications

(12 citation statements)

References 13 publications

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“…Figure (c) shows the effect of processing temperature on height of relief structures. The effect of processing temperature on photoembossing has also been studied . Similar to studies of other photopolymer systems, the height of the relief structures increases as the temperature increases till an optimum condition after which it begins to decrease.…”

Section: Resultsmentioning

confidence: 53%

“…temperature on photoembossing has also been studied. 25,28,33,34 Similar to studies of other photopolymer systems, the height of the relief structures increases as the temperature increases till an optimum condition after which it begins to decrease. However, unlike these photoembossing studies, relief structures could also be formed at room temperature below the Tg of the blend (Figure 3).…”

Section: Photoembossingmentioning

confidence: 53%

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Degradation and biocompatibility of photoembossed PLGA–acrylate blend for improved cell adhesion

et al. 2016

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We have shown previously that PMMA-acrylate photopolymers are biocomopatible and can exhibit improved cell adhesion compared to PMMA, due to an increase in negative surface charge caused by UV radiation PLGA has been used widely in soft tissue regeneration due to its high biocompatibility and cell adhesion. This polymer is also biodegradable and can be utilised in the field of vascular regeneration. In this study, PLGA is blended with a triacrylate monomer (TPETA) to create a degradable photopolymer blend. Surface relief structures are formed on this PLGA-TPETA by photoembossing. An optimum height of 950 nm was achieved for a 10 µm pitch with the height of these relief structures being controlled by changing UV intensity, processing temperature and time. Degradation studies of this blend revealed a bulk degradation mechanism with PLGA-TPETA degrading slower compared to pure PLGA. We also evaluated the adhesion of human umbilical vein endothelial cells (HUVECs) on both smooth and textured PLGA-TPETA films. Embossed PLGA-TPETA films showed improved cell adhesion compared to smooth substrates. Furthermore, HUVECs proliferated faster on the embossed surface compared to their smooth counterparts. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 163-171, 2018.

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Section: Resultsmentioning

confidence: 53%

Section: Photoembossingmentioning

confidence: 53%

Degradation and biocompatibility of photoembossed PLGA–acrylate blend for improved cell adhesion

et al. 2016

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“…Compared to photolithography, which is the most commonly used method to pattern thin films or substrates by microfabrication, photoembossing does not require a wet-etching step which makes it more cost-effective and environmental friendly. In this method, the shape of the relief structures is determined by the pattern of the photomask while our previous work has confirmed that the depth of the relief structures can be adjusted by controlling the UV dosage and temperature during the heating stage [25,27]. By this process of photoembossing and controlled UV dosages, we successfully fabricated photopolymer films with 1 µm high relief structures and 6, 10, and 20 µm pitches, as well as films with 2.5 µm high microstructures with a 20 µm pitch.…”

Section: Discussionmentioning

confidence: 99%

“…To produce smooth films as control substrates, after drying, the films were exposed to direct UV light for 1000 s causing all the monomers to polymerize. To produce surface textured samples, films were covered with a photomask and exposed to UV light for 30 s and then heated for 20 min at 120 °C to accelerate the diffusion of unreacted monomer, and which previous studies indicated as the optimum developing temperature [25]. Moreover, it was shown that there is an optimum UV dosage required to create any particular relief structure [25,26].…”

Section: Methodsmentioning

confidence: 99%

“…All these techniques are able to fabricate ordered topographies but are either time consuming, costly, or both. With the prospect that surface topography influences cell behaviour and increased surface roughness may enhance the adhesion, growth [24] and migration of endothelial cells, we patterned photopolymer films with different groove sizes by a technology called photoembossing [25,26,27], aiming to observe how human umbilical vein endothelial cells (HUVECs) will react on them. …”

Section: Introductionmentioning

confidence: 99%

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Responses of Vascular Endothelial Cells to Photoembossed Topographies on Poly(Methyl Methacrylate) Films

Qiu

Hughes-Brittain

Bastiaansen

et al. 2016

JFB

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Failures of vascular grafts are normally caused by the lack of a durable and adherent endothelium covering the graft which leads to thrombus and neointima formation. A promising approach to overcome these issues is to create a functional, quiescent monolayer of endothelial cells on the surface of implants. The present study reports for the first time on the use of photoembossing as a technique to create polymer films with different topographical features for improved cell interaction in biomedical applications. For this, a photopolymer is created by mixing poly(methyl methacrylate) (PMMA) and trimethylolpropane ethoxylate triacrylate (TPETA) at a 1:1 ratio. This photopolymer demonstrated an improvement in biocompatibility over PMMA which is already known to be biocompatible and has been extensively used in the biomedical field. Additionally, photoembossed films showed significantly improved cell attachment and proliferation compared to their non-embossed counterparts. Surface texturing consisted of grooves of different pitches (6, 10, and 20 µm) and heights (1 µm and 2.5 µm). The 20 µm pitch photoembossed films significantly accelerated cell migration in a wound-healing assay, while films with a 6 µm pitch inhibited cells from detaching. Additionally, the relief structure obtained by photoembossing also changed the surface wettability of the substrates. Photoembossed PMMA-TPETA systems benefited from this change as it improved their water contact angle to around 70°, making it well suited for cell adhesion.

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