Effect of polyhexanide as antiseptic mouth rinse against oral pathogens in an <i>in vitro</i> biofilm model

Kollmuß, Maximilian; Tolksdorf, Konrad; Wuersching, Sabina Noreen; Hickel, Reinhard; Huth, Kathleen

doi:10.1080/00016357.2021.1899280

Cited by 8 publications

(10 citation statements)

References 37 publications

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“…In the literature, the antibiofilm activity of some commercial QACs was noted. For example, chlorhexidine digluconate has a destructive effect on various cariogenic biofilms, , Streptococcus mutans biofilms, and mixed biofilms consisting of several bacteria of Spirochetes . Cetylpyridinium chloride, a pyridinium mono-QAC, is widely used to neutralize dental biofilms .…”

Section: Use Of Qacs Against Bacterial Biofilmsmentioning

confidence: 99%

“…It has been suggested that the main form of resistance of A. baumannii to biocides may be due to the formation of a biofilm rather than the expression of microbiocide resistance genes. Polyhexanide is a potent antibiofilm agent against S. aureus , C. albicans , P. aeruginosa , E. coli , P. mirabilis , S. mutans , Aggregatibacter actinomycetemcomitans , Actinomyces naeslundii , and Fusobacterium mucleatum strains. Liquid disinfectants containing QACs have been tested against dry-surface biofilms of S. aureus and P. aeruginosa .…”

Section: Use Of Qacs Against Bacterial Biofilmsmentioning

confidence: 99%

“…,111 E. coli, P. mirabilis,36 S. mutans, Aggregatibacter actinomycetemcomitans, Actinomyces naeslundii, and Fusobacterium mucleatum106 strains. Liquid disinfectants containing QACs have been tested against dry-surface biofilms of S. aureus and P. aeruginosa.…”

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confidence: 99%

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From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs)

et al. 2023

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In a previous development stage, mostly individual antibacterial activity was a target in the optimization of biologically active compounds and antiseptic agents. Although this targeting is still valuable, a new trend has appeared since the discovery of superhigh resistance of bacterial cells upon their aggregation into groups. Indeed, it is now well established that the great majority of pathogenic germs are found in the environment as surface-associated microbial communities called biofilms. The protective properties of biofilms and microbial resistance, even to high concentrations of biocides, cause many chronic infections in medical settings and lead to serious economic losses in various areas. A paradigm shift from individual bacterial targeting to also affecting more complex cellular frameworks is taking place and involves multiple strategies for combating biofilms with compounds that are effective at different stages of microbiome formation. Quaternary ammonium compounds (QACs) play a key role in many of these treatments and prophylactic techniques on the basis of both the use of individual antibacterial agents and combination technologies. In this review, we summarize the literature data on the effectiveness of using commercially available and newly synthesized QACs, as well as synergistic treatment techniques based on them. As an important focus, techniques for developing and applying antimicrobial coatings that prevent the formation of biofilms on various surfaces over time are discussed. The information analyzed in this review will be useful to researchers and engineers working in many fields, including the development of a new generation of applied materials; understanding biofilm surface growth; and conducting research in medical, pharmaceutical, and materials sciences. Although regular studies of antibacterial activity are still widely conducted, a promising new trend is also to evaluate antibiofilm activity in a comprehensive study in order to meet the current requirements for the development of highly needed practical applications.

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Section: Use Of Qacs Against Bacterial Biofilmsmentioning

confidence: 99%

Section: Use Of Qacs Against Bacterial Biofilmsmentioning

confidence: 99%

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From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs)

et al. 2023

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“…For in vitro assessments, polyhexanide (PHA) and polyhexamethylene biguanide (PHMB) are commonly employed for wound treatment as well as oral and ocular disinfection. [52,54] These agents exhibit promising outcomes in antimicrobial assays, effectively inhibiting F. nucleatum biofilms in vitro. More specifically, they have demonstrated a significant reduction in F. nucleatum survival relative to the control group, as confirmed by real-time PCR.…”

Section:  Polymersmentioning

confidence: 99%

Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges

Liu,

Yu,

Dong

et al. 2023

Exploration

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Colorectal cancer (CRC) is generally characterized by a high prevalence of Fusobacterium nucleatum (F. nucleatum), a spindle‐shaped, Gram‐negative anaerobe pathogen derived from the oral cavity. This tumor‐resident microorganism has been closely correlated with the occurrence, progression, chemoresistance and immunosuppressive microenvironment of CRC. Furthermore, F. nucleatum can specifically colonize CRC tissues through adhesion on its surface, forming biofilms that are highly resistant to commonly used antibiotics. Accordingly, it is crucial to develop efficacious non‐antibiotic approaches to eradicate F. nucleatum and its biofilms for CRC treatment. In recent years, various antimicrobial strategies, such as natural extracts, inorganic chemicals, organic chemicals, polymers, inorganic‐organic hybrid materials, bacteriophages, probiotics, and vaccines, have been proposed to combat F. nucleatum and F. nucleatum biofilms. This review summarizes the latest advancements in anti‐F. nucleatum research, elucidates the antimicrobial mechanisms employed by these systems, and discusses the benefits and drawbacks of each antimicrobial technology. Additionally, this review also provides an outlook on the antimicrobial specificity, potential clinical implications, challenges, and future improvements of these antimicrobial strategies in the treatment of CRC.

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“…Quaternary ammonium compounds (QACs) are a well-known class of cationic biocides exhibiting high antibacterial, − fungicidal, − antiviral, − and antibiofilm − activity. QACs are compounds with a positive charge on the nitrogen atom associated with four carbon-containing groups (alkyl, aryl, or heterocyclic).…”

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confidence: 99%

Multicationic Quaternary Ammonium Compounds: A Framework for Combating Bacterial Resistance

et al. 2023

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During previous stages of research, high biocidal activity toward microorganism archival strains has been used as the main indicator in the development of new antiseptic formulations. Although this factor remains one of the most important characteristics of biocide efficiency, the scale of antimicrobial resistance spread causes serious concern. Therefore, focus shifts toward the development of formulations with a stable effect even in the case of prolonged contact with pathogens. Here, we introduce an original isocyanuric acid alkylation method with the use of available alkyl dichlorides, which opened access to a wide panel of multi-QACs with alkyl chains of various lengths between the nitrogen atoms of triazine and pyridine cycles. We used a complex approach for the resulting series of 17 compounds, including their antibiofilm properties, bacterial tolerance development, and antimicrobial activity toward multiresistant pathogenic strains. As a result of these efforts, available compounds have shown higher levels of antibacterial activity against ESKAPE pathogens than widely used commercial QACs. Hit compounds possessed high activity toward clinical bacterial strains and have also demonstrated a long-term biocidal effect without significant development of microorganism tolerance. The overall results indicated a high level of antibacterial activity and the broad application prospects of multi-QACs based on isocyanuric acid against multiresistant bacterial strains.

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Effect of polyhexanide as antiseptic mouth rinse against oral pathogens in an in vitro biofilm model

Cited by 8 publications

References 37 publications

From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs)

From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs)

Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges

Multicationic Quaternary Ammonium Compounds: A Framework for Combating Bacterial Resistance

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