“…Introduction 1) Polygoni Multiflori Radix (PMR), the roots of Polygonum multiflorum Thunberg, is used to tonify the liver and kidney, nourish the blood, and augment the essence and used for the treatment of the patterns of yin or blood deficiency with such signs as dizziness, blurred vision, premature greying of the hair, weakness in lower back and knees, soreness in the exremities, nocturenal emissions, and insomnia 1,2) . According to recent studies, PMR has many pharmacological actions, such as anti-oxidation 3) , neuroprotection 4) , anti-cancer 5) , hair growing effect of resting hair follicles 6) , anti-inflammation 7) , reducing the blood lipids 8) , and anti-osteoporosis 9) . Solar ultraviolet (UV) radiation accelerates premature aging (photoaging), the symptoms of which include leathery texture, wrinkles, mottled pigmentation, laxity and sallowness 10) .…”