Effect of polyethylene glycol (PEG) chain organization on the physicochemical properties of poly(d, l-lactide) (PLA) based nanoparticles

Essa, Sherief; Rabanel, Jean‐Michel; Hildgen, Patrice

doi:10.1016/j.ejpb.2010.03.002

Cited by 83 publications

(56 citation statements)

References 40 publications

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“…2D). Burst release phenomenon is attributed to drug attached on or close to the surface of the NP (Essa et al, 2010). These results suggest that there is a higher amount of insulin attached to the PEGylated NP surface compared to PLGA NP because of presence of PEG chains.…”

Section: Effect Of Polymer Typementioning

confidence: 79%

Preparation and in vivo evaluation of insulin-loaded biodegradable nanoparticles prepared from diblock copolymers of PLGA and PEG

Haggag

Abdel-Wahab

Ojo

et al. 2016

International Journal of Pharmaceutics

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A B S T R A C TThe aim of this study was to design a controlled release vehicle for insulin to preserve its stability and biological activity during fabrication and release. A modified, double emulsion, solvent evaporation, technique using homogenisation force optimised entrapment efficiency of insulin into biodegradable nanoparticles (NP) prepared from poly (DL-lactic-co-glycolic acid) (PLGA) and its PEGylated diblock copolymers. Formulation parameters (type of polymer and its concentration, stabiliser concentration and volume of internal aqueous phase) and physicochemical characteristics (size, zeta potential, encapsulation efficiency, in vitro release profiles and in vitro stability) were investigated. In vivo insulin sensitivity was tested by diet-induced type II diabetic mice. Bioactivity of insulin was studied using Swiss TO mice with streptozotocin-induced type I diabetic profile. Insulin-loaded NP were spherical and negatively charged with an average diameter of 200-400 nm. Insulin encapsulation efficiency increased significantly with increasing ratio of co-polymeric PEG. The internal aqueous phase volume had a significant impact on encapsulation efficiency, initial burst release and NP size. Optimised insulin NP formulated from 10% PEG-PLGA retained insulin integrity in vitro, insulin sensitivity in vivo and induced a sustained hypoglycaemic effect from 3 h to 6 days in type I diabetic mice..

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Section: Effect Of Polymer Typementioning

confidence: 79%

Preparation and in vivo evaluation of insulin-loaded biodegradable nanoparticles prepared from diblock copolymers of PLGA and PEG

Haggag

Abdel-Wahab

Ojo

et al. 2016

International Journal of Pharmaceutics

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“…The bright regions are likely the crystallized PLA and hard segments. 31,50 The hard segment region formed by hydrogen bonding 31 becomes irregular spherical structures as shown in Fig. 8b.…”

Section: Stxm and Afm Observation And Toughening Mechanism Of The Plamentioning

confidence: 99%

Enhanced mechanical properties of PLA/PLAE blends via well-dispersed and compatilized nanostructures in the matrix

Cai

Zeng

Zhang³

et al. 2016

RSC Adv.

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Polylactide (PLA) was toughened by a PLA-based thermoplastic elastomer (PLAE). PLAE was prepared by chain extension of PLA copolymer derived from polylactic acid (PLA) and poly(tetramethylene ether glycol) (PTMEG) via melt polycondensation. The tensile strength of the toughened-PLA (PLAE30) reached 70 MPa, while the elongation at break was found to be above 140% compared to its plain PLA counterpart. The relationship between the phase morphology of the blends and their mechanical behavior was investigated with atomic force microscopy (AFM), scanning electron microscopy (SEM), and scanning transmission X-ray microscopy (STXM). It was found that the well-dispersed nanoscale structures in the matrix of PLA/PLAE blends are mainly responsible for the significantly enhanced mechanical properties. Also discussed are the detailed microstructural development in PLAE and the toughening mechanism.

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“…The ability of PEG to form small pores in the surfaces of the microspheres was reported for microparticles based on blends of PLGA/PLA and PEG and also applies to microparticles composed of diblock polymer [79]. During the precipitation step, the PEG branches of the diblock copolymer orientated toward the internal and surrounding aqueous phase and formed a sponge-like structure [80]. Finally, the heating experiments in AC magnetic field were performed on a medium frequency induction heating apparatus.…”

Section: Synthesis Of Ugi Magnetic Compositementioning

confidence: 99%

PLA-b-PEG/magnetite hyperthermic agent prepared by Ugi four component condensation

Icart¹,

Santos²,

Pereira³

et al. 2016

Express Polym. Lett.

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Effect of polyethylene glycol (PEG) chain organization on the physicochemical properties of poly(d, l-lactide) (PLA) based nanoparticles

Cited by 83 publications

References 40 publications

Preparation and in vivo evaluation of insulin-loaded biodegradable nanoparticles prepared from diblock copolymers of PLGA and PEG

Preparation and in vivo evaluation of insulin-loaded biodegradable nanoparticles prepared from diblock copolymers of PLGA and PEG

Enhanced mechanical properties of PLA/PLAE blends via well-dispersed and compatilized nanostructures in the matrix

PLA-b-PEG/magnetite hyperthermic agent prepared by Ugi four component condensation

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