Effect of polyethylene glycol 400 on adriamycin induced histamine release

Decorti, Giuliana; Klugmann, Fiora Bartoli; Candussio, Luigi; Basa, M; Mallardi, Franco; Grill, Vittorio; Baldini, L

doi:10.1016/0277-5379(86)90365-2

European Journal of Cancer and Clinical Oncology

1986

DOI: 10.1016/0277-5379(86)90365-2

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Effect of polyethylene glycol 400 on adriamycin induced histamine release

Giuliana Decorti

Fiora Bartoli Klugmann

Luigi Candussio

et al.

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Cited by 5 publications

(1 citation statement)

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“…Chronic cardiac effects may also be related to histamine and catecholamine release, as, in rabbits, pretreatment with antihistamines and antiadrenergics prevents the majority of cardiac tissue damage (Bristow et al, 1981). Adriamycin induces peritoneal mast cell degranulation when injected intraperitoneally in mice (Decorti et al, 1986a); in addition, this substance and other anthracyclines cause a significant and dose dependent histamine release from rat peritoneal cells in vitro in a non cytotoxic manner (Decorti et al, 1986b).…”

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confidence: 99%

Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo

Fb¹,

Decorti²,

Candussio³

et al. 1986

Br J Cancer

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The activity of theophylline and disodium cromoglycate was tested on adriamycin-induced histamine release in vitro and on adriamycin cardiotoxicity in vivo. Both substances significantly inhibited the release of histamine induced by 100 micrograms ml-1 of adriamycin on rat peritoneal cells and produced significant protection against adriamycin-mediated acute and chronic cardiotoxicity in mice. N-acetylcysteine, a free radical scavenger, successfully used in the prevention of the cardiomyopathy, was also found to be an inhibitor of histamine release induced by adriamycin and compound 48/80 on rat peritoneal cells. This study further supports the hypothesis that the release of histamine may be involved in the pathogenesis of anthracycline cardiotoxicity. Images Figure 5 Figure 6 Figure 7 Figure 8

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mentioning

confidence: 99%

Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo

Fb¹,

Decorti²,

Candussio³

et al. 1986

Br J Cancer

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Interaction of adriamycin with rat and mouse mast cells: Histamine release and cellular uptake

et al. 1989

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In the present study, we evaluated in mouse and rat mast cells if adriamycin uptake is related to histamine release. In addition, the uptake of the antineoplastic drug and histamine release were studied in other normal and neoplastic cell lines. The effect of sodium cromoglycate was also examined. Adriamycin induced histamine release from mixed or purified mast cells of the mouse and rat. This exocytotic response was quantitatively related to intracellular concentrations of adriamycin. Significant differences in adriamycin uptake were observed between mast cells and other normal and neoplastic cells. When peritoneal mast cells were treated with sodium cromoglycate, histamine release and adriamycin uptake were significantly reduced. In contrast, incubation of other cells with cromoglycate only slightly reduced the cellular concentration of the antineoplastic drug.

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Amelioration of 4′-epidoxorubicin-induced cardiotoxicity by sodium cromoglycate

Klugmann¹,

Decorti²,

Candussio³

et al. 1989

European Journal of Cancer and Clinical Oncology

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Effect of polyethylene glycol 400 on adriamycin induced histamine release

Cited by 5 publications

References 16 publications

Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo

Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo

Interaction of adriamycin with rat and mouse mast cells: Histamine release and cellular uptake

Amelioration of 4′-epidoxorubicin-induced cardiotoxicity by sodium cromoglycate

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