Effect of polyenephosphatidylcholine on cholesterol uptake by human high density lipoprotein

Effect of High Density Lipoproteins Modified with Dilinoleoylphosphatidylcholine Vesicles on [3H]Cholesterol Release from Macrophages

“…In our assay system, LCAT activity was negligible; but the release of [3H]cholesterol occurred, indicating that the fluidity of the acceptor phospholipid and apolipoproteins were important in the first two steps. These conclusions are consistent with the report of Zierenberg et al [7] that cholesterol transfer is not dependent on LCAT activity and that the surface properties of HDL are the limiting factor for cholesterol uptake and not the activity of LCAT [7].…”

“…Thus, treatment that increases in the HDL level may prevent cardiovascular disease. HDL can be modified by incubation with polyenephosphatidylcholine (PPC), which results in a change in the fluidity of the lipoprotein [7].…”

Aging and chronic illnesses: Membrane Lipid Replacement for restoring mitochondrial function and reducing fatigue, pain, and other symptoms in aged individuals

“…When present in excess in the gastrointestinal system, they can be absorbed as small phospholipid globules and micelles with undegraded constituents (reviewed in [11]). Independent of the transport mechanism, the process is very efficient-over 90% of ingested phospholipids are absorbed and transported into the blood within six hours [15][16][17]. In the blood circulation phospholipids are usually found in carrier molecules, such as lipoproteins, or cell membranes of erythrocytes; but in excess they can also be present as small phospholipid globules or micelles.…”

“…In the blood circulation phospholipids are usually found in carrier molecules, such as lipoproteins, or cell membranes of erythrocytes; but in excess they can also be present as small phospholipid globules or micelles. Eventually they are delivered to tissues and cells where they are transferred by direct membrane contact, endocytosis or by carrier and transport proteins into cells where they are directed to various cellular and organelle membranes and compartments [11,[15][16][17].…”

Cholesterol-Lowering and HDL-Raising Properties of Lecithinated Soy Proteins in Type II Hyperlipidemic Patients

“…Studies on the effects of L on plasma lipid-lipoprotein levels and on atherosclerosis prevention, have been controversial [26,27], Metabolic studies with polyunsaturated L from soybean in healthy volunteers have shown that these are secreted from the intestine within small very low-den sity lipoproteins (VLDL) [28], followed by a transfer to HDL, which may contain 2 to 6-fold higher levels of exogenous L, compared to the other lipoproteins [29], L-modified HDL seem to have a markedly enhanced capacity for cholesterol storage [30]. If this is the case, patients with low starting HDL-C levels would be more likely to benefit from this treatment.…”