Effect of Polydeoxyribonucleotide on Chondrocutaneous Composite Grafts Survival

Heo, Jae Won; Kim, Yong Hun; Kim, Eon Su; Kim, Sug Won; Kim, Ji-Ye

doi:10.1007/s00266-019-01400-x

Cited by 2 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of nine studies have evaluated the wound healing activity of Ok- (six studies) and Om-PDRNs (three studies) [ 4 , 8 , 9 , 27 , 28 , 45 , 46 , 47 ]. In the case of Ok-PDRN, one study has evaluated the effective range of Ok-PDRN for wound healing as a function of molecular weight distributions (under 50 kDa, between 50 and 1500 kDa, over 1500 kDa) [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

“…The authors also observed less lipid accumulation in the PDRN groups and normal wound healing (i.e., not excessive wound healing). A 2019 study hypothesized and confirmed that Ok-PDRN promotes the survival of composite grafts [ 45 ]. Ok-PDRN (0.75 mg/kg) was injected evenly into the surrounding skin of the composite graft, whereas normal saline (0.9% NaCl) was used as a negative control.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering

Kim

Heo

et al. 2021

Marine Drugs

View full text Add to dashboard Cite

Polydeoxyribonucleotides (PDRNs) are a family of DNA-derived drugs with a molecular weight ranging from 50 to 1500 kDa, which are mainly extracted from the sperm cells of salmon trout or chum salmon. Many pre-clinical and clinical studies have demonstrated the wound healing and anti-inflammatory properties of PDRN, which are mediated by the activation of adenosine A2A receptor and salvage pathways, in addition to promoting osteoblast activity, collagen synthesis, and angiogenesis. In fact, PDRN is already marketed due to its therapeutic properties against various wound healing- and inflammation-related diseases. Therefore, this review assessed the most recent trends in marine organism-derived PDRN using the Google Scholar search engine. Further, we summarized the current applications and pharmacological properties of PDRN to serve as a reference for the development of novel PDRN-based technologies.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering

Kim

Heo

et al. 2021

Marine Drugs

View full text Add to dashboard Cite

show abstract

“…Similarly, PDRN restored perfusion by increasing neovascularization, as assessed by histological and optical methods, in auricular chondrocutaneous composite grafts in rabbits. 61…”

Section: Pdrn and The Resolution Of Inflammationmentioning

confidence: 99%

Polydeoxyribonucleotide Regulation of Inflammation

Colangelo

Galli

Guizzardi

2020

Advances in Wound Care

View full text Add to dashboard Cite

Significance: Dysregulated inflammation is a critical factor in the development of a wide range of diseases. Controlling inflammatory responses can be challenging because available treatment options are often limited. This review discusses the ability of polydeoxyribonucleotides (PDRN) to modulate inflammation and the evidence that supports it. Recent Advances: PDRN is known in the clinical field for its regenerative properties. This action is partially related to the stimulation of the purinergic system through adenosine A2A receptors (A2ARs). Recently, the topical antiinflammatory effects of PDRN have aroused much interest, with a growing body of research supporting its use for the management of several inflammatory states. Critical Issues: Impaired tissue repair and several metabolic disorders are associated with chronic inflammation. Despite the growing clinical concern, an optimal and sustainable therapy for different inflammatory conditions has not yet been established, and current treatments are often limited by their short-term efficacies and side effects. Future Directions: The present review provides an updated summary of the ability of PDRN to control inflammation as observed in several in vitro studies, simplified models of the main biological mechanisms mediating its anti-inflammatory effect, and confirmed in vivo and clinical models. It analyzes the therapeutic potential of PDRN in terms of its mechanism of action through A2AR activation, its efficacy and its complications compared with those of current anti-inflammatory drugs.

show abstract

Effect of Polydeoxyribonucleotide on Chondrocutaneous Composite Grafts Survival

Cited by 2 publications

References 28 publications

Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering

Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering

Polydeoxyribonucleotide Regulation of Inflammation

Contact Info

Product

Resources

About