Effect of polychlorinated biphenyls (PCBs) accumulated in the dam's body on mouse filial immunocompetence

Takagi, Yasuhiro; Aburada, Satoshi; Otake, T.; Ikegami, Nobuko

doi:10.1007/bf01054956

Cited by 20 publications

(6 citation statements)

References 28 publications

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“…Such associations are consistent with many laboratory experiments that have found severe impacts of HAHs on Tcell-mediated immunity in birds and mammals (22,26,32,33,(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47). In a parallel investigation that studied herring gull chicks at nine colonies in the Great Lakes and one colony on the Atlantic coast, thymic atrophy was associated with increasing liver EROD activity (89).…”

Section: )supporting

confidence: 65%

Organochlorine-Associated Immunosuppression in Prefledgling Caspian Terns and Herring Gulls from the Great Lakes: An Ecoepidemiological Study

Grasman¹,

Fox²,

Scanlon³

et al. 1996

Environmental Health Perspectives

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The objectives of this study were to determine whether contaminant-associated immunosuppression occurs in prefledgling herring gulls and Caspian terns from the Great Lakes and to evaluate immunological biomarkers for monitoring health effects in wild birds. During 1992 to 1994, immunological responses and related variables were measured in prefledgling chicks at colonies distributed across a broad gradient of organochlorine contamination (primarily polychlorinated biphenyls), which was measured in eggs. The phytohemagglutinin skin test was used to assess T-lymphocyte function. In both species, there was a strong exposure-response relationship between organochlorines and suppressed T-cell-mediated immunity. Suppression was most severe (30-45%) in colonies in Lake Ontario (1992) and Saginaw Bay (1992)(1993)(1994) for both species and in western Lake Erie (1992) for herring gulls. Both species exhibited biologically significant differences among sites in anti-sheep red blood cells antibody titers, but consistent exposure-response relationships with organochlorines were not observed. In Caspian terns and, to a lesser degree, in herring gulls, there was an exposure-response relationship between organochlorines and reduced plasma retinol (vitamin A). In 1992, altered white blood cell numbers were associated with elevated organochlorine concentrations in Caspian terns but not herring gulls. The immunological and hematological biomarkers used in this study revealed contaminantassociated health effects in wild birds. An epidemiological analysis strongly supported the hypothesis that suppression of T-cell-mediated immunity was associated with high perinatal exposure to persistent organochlorine contaminants.Environ Health Perspect 104(Suppl 4): 829-842 (1996)

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Section: )supporting

confidence: 65%

Organochlorine-Associated Immunosuppression in Prefledgling Caspian Terns and Herring Gulls from the Great Lakes: An Ecoepidemiological Study

Grasman¹,

Fox²,

Scanlon³

et al. 1996

Environmental Health Perspectives

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“…KERKVUET thymus gland could have serious and longlasting consequences in terms of immune function since the thymus gland is critical for the selection of T cells that can appropriately discriminate between self and nonself molecules (18). Several studies suggest that prenatal exposure of mice or rats to TCDD is more immunosuppressive than comparable exposure of adults (19)(20)(21)(22)(23) (24).…”

Section: Immunotoxicity Studies Laboratory Animal Studiesmentioning

confidence: 99%

Immunological Effects of Chlorinated Dibenzo-p-Dioxins

Kerkvliet¹

1995

Environmental Health Perspectives

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“…Four-week-old mice exposed prenatally to a commercial PCB mixture (Kanechlor 500) displayed T-helper activity reduced to 20% of control levels (47). In another report, in utero exposure of mice to PCB resulted in fetal thymic hypoplasia and inhibited lymphoid cell development in thymic organ culture (thymi taken from 14-day embryos) (48).…”

Section: Development Of the Immune Systemmentioning

confidence: 99%

Development of the murine and human immune system: differential effects of immunotoxicants depend on time of exposure.

Holladay

Smialowicz

2000

Environ Health Perspect

236

177

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Fetal and early postnatal life represent critical periods in vertebrate immune system development. Disruption of such development by perinatal immunotoxic chemical exposure has been widely described in experimental animal models. The resultant inhibited postnatal immune responses in such animals are often more dramatic and persistent than those after exposure during adult life. Further, recent reports suggest that prenatal exposure to immunotoxicants may exacerbate postnatal aberrant immune responses (e.g., hypersensitivity disorders and autoimmune disease) in genetically predisposed rodents. Limited information is available regarding the possibility of inhibited postnatal immune capacity in humans as a result of developmental immunotoxicant exposure. The multifactorial nature of hypersensitivity and autoimmune responses will further complicate the elucidation of possible relationships between chemical exposure during ontogeny of the human immune system and immune-mediated disease later in life. Taken together, however, the available animal data suggest the potential for altered postnatal immune function in humans exposed to immunotoxicants (e.g., environmental chemicals and therapeutic agents) during fetal and/or early postnatal life.

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Effect of polychlorinated biphenyls (PCBs) accumulated in the dam's body on mouse filial immunocompetence

Cited by 20 publications

References 28 publications

Organochlorine-Associated Immunosuppression in Prefledgling Caspian Terns and Herring Gulls from the Great Lakes: An Ecoepidemiological Study

Organochlorine-Associated Immunosuppression in Prefledgling Caspian Terns and Herring Gulls from the Great Lakes: An Ecoepidemiological Study

Immunological Effects of Chlorinated Dibenzo-p-Dioxins

Development of the murine and human immune system: differential effects of immunotoxicants depend on time of exposure.

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