Effect of polyamidoamine dendrimer G3 and G4 on skin permeation of 8-methoxypsoralene—In vivo study

Borowska, Katarzyna; Wołowiec, Stanisław; Rubaj, Andrzej; Głowniak, Kazimierz; Sieniawska, Elwira; Radej, Sebastian

doi:10.1016/j.ijpharm.2012.01.041

Cited by 63 publications

(23 citation statements)

References 25 publications

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“…Furthermore, there exists ample evidence in the literature of nonpeptidic dendrimers increasing skin permeation/ deposition of drugs through complex formation, this Loss of drug (%) compared to drug alone (Yiyun et al, 2007;Venuganti & Perumal, 2008;Borowska et al, 2012). In this study, this attractive property can be extended to peptide dendrimers, given that 5-FU-peptide dendrimer complexes were allowed to form in the donor solution (2-3 h) prior to conducting diffusion studies.…”

Section: -Fu In Vitro Skin Permeation Studiesmentioning

confidence: 96%

Enhancement in deposition and permeation of 5-fluorouracil through human epidermis assisted by peptide dendrimers

et al. 2013

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Enhancing the deposition and permeation of 5-fluorouracil across human epidermis assisted by appropriately charged and well-defined peptide dendrimers was investigated. Peptide dendrimers with arginine as the terminal amino acid and having a range of terminal positive charges (4þ and 16 þ ) were synthesized by solid phase peptide synthesis. Various parameters including effect of peptide dendrimers on the solubility and partition coefficient of 5-FU, degradation of drug in skin as well as deposition and permeation of 5-FU in/through skin were studied. All the tested dendrimers increased the aqueous solubility and partition coefficient of 5-FU with each also significantly (p50.05) enhancing the deposition and permeation of 5-FU in/across human epidermis in a concentration-dependent manner. Of the three peptide dendrimers examined, R8 dendrimer (bearing 8 þ charge derived from four terminal arginines and MW of &1000 Da) showed greatest values for flux, Q 48 (cumulative amount of drug permeated at the end of 48 h) and amount of drug retained in human skin. Furthermore, this study also scrutinized and reports on the likely mechanisms by which peptide dendrimers act as transdermal permeation enhancers.

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Section: -Fu In Vitro Skin Permeation Studiesmentioning

confidence: 96%

Enhancement in deposition and permeation of 5-fluorouracil through human epidermis assisted by peptide dendrimers

et al. 2013

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“…In addition, transdermal delivery of other drugs, such as 8-methoxypsoralen (8-MOP), could also be enhanced by the PAMAM dendrimers (G3-NH 2 and G4-NH 2 ) both in vitro and in vivo. Confocal images revealed that 8-MOP could transport into the deeper layers of the skin than the single drug solution (Borowska et al, 2010(Borowska et al, , 2012.…”

Section: Dendrimersmentioning

confidence: 98%

Biomaterials as novel penetration enhancers for transdermal and dermal drug delivery systems

2013

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The highly organized structure of the stratum corneum provides an effective barrier to the drug delivery into or across the skin. To overcome this barrier function, penetration enhancers are always used in the transdermal and dermal drug delivery systems. However, the conventional chemical enhancers are often limited by their inability to delivery large and hydrophilic molecules, and few to date have been routinely incorporated into the transdermal formulations due to their incompatibility and local irritation issues. Therefore, there has been a search for the compounds that exhibit broad enhancing activity for more drugs without producing much irritation. More recently, the use of biomaterials has emerged as a novel method to increase the skin permeability. In this paper, we present an overview of the investigations on the feasibility and application of biomaterials as penetration enhancers for transdermal or dermal drug delivery systems.

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“…For example, 8-methoxypsoralen, a compound used in psoralen ultraviolet A therapy [115], had been formulated into niosomal vesicles and delivered topically to increase its local efficacy and safety [116]. Another group of investigators has attempted to develop a niosomal gel formulation with acyclovir that has a superior topical bioavailability [117].…”

Section: Other Applicationsmentioning

confidence: 99%

Niosomes: a review of their structure, properties, methods of preparation, and medical applications

et al. 2017

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Target-specific drug-delivery systems for the administration of pharmaceutical compounds enable the localization of drugs to diseased sites. Various types of drug-delivery systems utilize carriers, such as immunoglobulins, serum proteins, synthetic polymers, liposomes, and microspheres. The vesicular system of niosomes, with their bilayer structure assembled by nonionic surfactants, is able to enhance the bioavailability of a drug to a predetermined area for a period. The amphiphilic nature of niosomes promotes their efficiency in encapsulating lipophilic or hydrophilic drugs. Other additives, such as cholesterol, can be used to maintain the rigidity of the niosomes' structure. This narrative review describes fundamental aspects of niosomes, including their structural components, methods of preparation, limitations, and current applications to various diseases.

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Effect of polyamidoamine dendrimer G3 and G4 on skin permeation of 8-methoxypsoralene—In vivo study

Cited by 63 publications

References 25 publications

Enhancement in deposition and permeation of 5-fluorouracil through human epidermis assisted by peptide dendrimers

Enhancement in deposition and permeation of 5-fluorouracil through human epidermis assisted by peptide dendrimers

Biomaterials as novel penetration enhancers for transdermal and dermal drug delivery systems

Niosomes: a review of their structure, properties, methods of preparation, and medical applications

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