Effect of Poly Unsaturated Fatty Acids Administration on Children with Attention Deficit Hyperactivity Disorder: A Randomized Controlled Trial

Anand, Puneet; Sachdeva, Ankur

doi:10.7860/jcdr/2016/20423.8471

Cited by 16 publications

(23 citation statements)

References 28 publications

(4 reference statements)

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“…The medication was given on a daily basis for four months to a total of 50 children. Although PUFAs improved ADHD symptoms, this experiment showed no clinically significant difference in the ADHD Conners Parent rating scale, questioning the overall therapeutic effect of PUFAs against ADHD, even if some beneficial effects are evident [188]. Supporting these results, a systematic review discussing results of 14 meta-analyses inducing PUFAs to ADHD children showed a very small effect size when parents and teachers rated children's behavior using the Conners scale [189].…”

Section: Polyunsaturated Fatty Acidsmentioning

confidence: 68%

“…As the levels of SCFAs [174] and PUFAs [185] are positively correlated with BDNF, omega-3 fatty acids may prove to be of therapeutic importance. So far, various studies have shown that adding PUFAs to the diet only marginally decreases the symptoms of ADHD [188][189][190]. Future studies could assess the effects of various concentrations of PUFAs and age at which these were ingested on the symptom development of ADHD.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, many studies including a double-blind trial [188] assessed the effects of inducing the noradrenaline reuptake inhibitor (Atomoxetine) conventionally used to treat ADHD, to the patient and the control group and PUFAs, such as eicosapentanoic acid (EPA) and DHA solely to the ADHD patients. The medication was given on a daily basis for four months to a total of 50 children.…”

Section: Polyunsaturated Fatty Acidsmentioning

confidence: 99%

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The Potential Influence of the Microbiome on the Development and Progression of ADHD

Bull-Larsen¹,

Mohajeri²

2019

Preprint

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The latest research cumulates staggering information about the correlation between the microbiota-gut-brain axis and neurodevelopmental disorders. This review aims to shed light on the potential influence of the microbiome on the development of the most prevalent neurodevelopmental disease, attention-deficit-hyperactive disorder (ADHD). As the etiology and pathophysiology of ADHD are still unclear, finding viable biomarkers and effective treatment still represent a challenge. Therefore, we focused on factors that have been associated with a higher risk of developing ADHD while simultaneously influencing the microbial composition. We reviewed the effect of a differing microbial composition on neurotransmitter concentrations important in the pathophysiology of ADHD. Additionally, we deduced factors that correlate with a high prevalence of ADHD while simultaneously affecting the gut microbiome such as emergency c-sections, and premature birth as the former leads to a decrease of the gut microbial diversity and the latter causes neuroprotective Lactobacillus levels to be reduced. Also, we assessed nutritional influences such as breastfeeding, ingestion of short-chain fatty acids (SCFAs) and polyunsaturated fatty acids (PUFAs) on the host's microbiome and development of ADHD. Finally, we discussed the potential significance of Bifidobacterium as a biomarker for ADHD, the importance of preventing premature birth as prophylaxis and nutrition as a prospective therapeutic measurement against ADHD.

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Section: Polyunsaturated Fatty Acidsmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Polyunsaturated Fatty Acidsmentioning

confidence: 99%

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The Potential Influence of the Microbiome on the Development and Progression of ADHD

Bull-Larsen¹,

Mohajeri²

2019

Preprint

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“…Studies in children with neurodevelopmental disorders have demonstrated lower levels of n-3 PUFAs, a higher ratio of n-6/n-3 PUFAs, and high correlation between PUFA dysregulation and symptom severities [62,63]. In a randomized attention-deficit/hyperactivity disorder (ADHD) study, the n-3 PUFA supplemented group had a greater reduction in ADHD scores compared to the control group, suggesting that n-PUFA plays a major role in maintaining brain function and development in neurodevelopmental populations [64]. In an fMRI study, 33 healthy boys were randomly assigned either 400 mg/day or 1200 mg/day of DHA or corn oil for 8 weeks.…”

Section: Discussionmentioning

confidence: 99%

Personalized polyunsaturated fatty acids as a potential adjunctive treatment for anorexia nervosa

Shih

Morisseau

et al. 2017

Prostaglandins & Other Lipid Mediators

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Anorexia nervosa (AN) is a complex psychiatric disorder with high morbidity and mortality rates. While many individuals make full recoveries, up to a third of patients develop a chronic, treatment-resistant form of the illness that leads to a premature death in 15–20% of those affected. There have been few advances in treatment, both in terms of psychological or pharmacologic treatment over the last 30 years. Food aversion is commonly cited by patients with AN as a barrier to normalizing eating and weight. Our group has a keen interest in examining factors that might allow this to be addressed, thus improving treatment outcomes through personalized dietary plans or nutritional supplementation related to underlying genetic status. We demonstrated that polyunsaturated fatty acids (PUFAs)-derived bioactive lipids (eicosanoids) are implicated in not only the risk of AN, but also with its comorbid psychopathology. Of interest, the differential postprandial omega 6-derived eicosanoid shift observed in AN highlights the possibility that the metabolism of PUFAs is an important mechanism underlying the profound food version, contributing to pathological food restriction in AN. A concise knowledge of the relationships among PUFAs, eicosanoids, and AN clinical course and psychopathology could be the key to developing personalized nutritional rehabilitative treatments for those suffering from AN. This paper provides a comprehensive overview of the literature on PUFAs in AN. We also selectively reviewed the clinical benefits PUFA treatments exert in other psychiatric diseases, on weight and appetite regulation, and for resolution of inflammation, all of which are relevant in the disease course and outcome of AN. We propose that personalized PUFA formulation be developed and tested as a novel adjunctive treatment for patients with AN. We hypothesize that with personalized PUFA formulation, food aversion and anxiety about eating will decrease while mood, dietary behavior, and weight restoration will improve in AN, leading to improvements in the overall treatment outcome.

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“…Some of the early studies on children with ADHD focused on supplementation with DHA alone showed little or no therapeutic effect. 30,31 Other clinical trials on children with ADHD who were supplemented with evening primrose oil or formulas rich in omega-6 were summarized as of little or no effect on ADHD. 32,33 Very few trials employed comparable experimental designs, supplements, doses, and duration of supplementation.…”

Section: Pufas Supplementation For Adhdmentioning

confidence: 99%

Omega-3 Supplementation for Children with Learning Difficulties and Attention Deficit Disorder: Is it Beneficial?

Gadoth

2019

J Pediatr Neurol

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The use of “natural medicines,” food supplements, and in particular long-chain polyunsaturated fatty acids (omega-3/6) for a large variety of ailments including attention deficit hyperactivity disorder (ADHD) and other developmental behavioral disorders has dramatically increased in the past few years. In recent publications, doubts have been raised in regard to the benefits and risks of this form of treatment for ADHD. In this article, a short history of the way this treatment has evolved, its theoretical basis, and evidence-based data on the value of this popular supplementation will be reviewed.

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Effect of Poly Unsaturated Fatty Acids Administration on Children with Attention Deficit Hyperactivity Disorder: A Randomized Controlled Trial

Cited by 16 publications

References 28 publications

The Potential Influence of the Microbiome on the Development and Progression of ADHD

The Potential Influence of the Microbiome on the Development and Progression of ADHD

Personalized polyunsaturated fatty acids as a potential adjunctive treatment for anorexia nervosa

Omega-3 Supplementation for Children with Learning Difficulties and Attention Deficit Disorder: Is it Beneficial?

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