Effect of platinum-containing chemotherapy on olfactory, gustatory, and hearing function in ovarian cancer patients

Steinbach, Silke; Hundt, Walter; Schmalfeldt, Barbara; Böhner, Christina; Berktold, Sabina; Wolf, Petra; Harbeck, Nadia

doi:10.1007/s00404-012-2307-5

Cited by 23 publications

(10 citation statements)

References 23 publications

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“…These results were reaffirmed by a following study investigating 12 ovarian cancer patients receiving carboplatin containing chemotherapy [12]. In accordance with our results, in both studies [11,12] odor identification of patients undergoing chemotherapy was hardly affected, whereas odor threshold score significantly decreased. These results were confirmed by other research investigating olfactory function of patients undergoing cisplatin containing chemotherapy protocols, that showed odor ID unaffected [7,13].…”

Section: Discussionsupporting

confidence: 94%

“…All patients presented a normal olfactory function after completing therapy. These results were confirmed by other studies [8,11,12]. This is not surprising as olfactory sensory cells are unique among the sensory cells of humans because they are capable for renewing.…”

Section: Discussionsupporting

confidence: 92%

“…In addition, in a cohort of 87 cancer patients (breast cancer or gynecologic malignancies) undergoing various chemotherapy regimens (27% of those platinum containing) it could be demonstrated that olfactory function decreased significantly during chemotherapy but recovered almost completely after termination of the therapy [13]. These results were reaffirmed by a following study investigating 12 ovarian cancer patients receiving carboplatin containing chemotherapy [12]. In accordance with our results, in both studies [11,12] odor identification of patients undergoing chemotherapy was hardly affected, whereas odor threshold score significantly decreased.…”

Section: Discussionsupporting

confidence: 49%

“…As the subjective rating of olfactory function has been shown to be notoriously inaccurate, it is necessary to measure olfactory function [5]. There are some studies which measured olfactory function psychophysically during versus after chemotherapy with inconclusive findings though [2][3][4][5][6][7][8][9][10][11][12][13][14]. However, chemosensory alterations, especially olfactory and taste distortions have been reported in cancer patients in general.…”

Section: Introductionmentioning

confidence: 99%

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Testicular cancer patients undergoing cisplatin based chemotherapy exhibit temporary olfactory threshold scores changes

Walliczek‐Dworschak

Gudziol

Mitzschke

et al. 2017

Eur Arch Otorhinolaryngol

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Testicular cancer is the most frequent malignant disease in young males between 15 and 35 years. Platinum based chemotherapy regimen is the therapy of choice in advanced disease. This treatment has also adverse effects caused by the cytostatic active substances, such as olfactory dysfunctions. The aim of this study was, therefore, to monitor olfactory function of testicular cancer patients during and 6 months after chemotherapy. A total of 17 patients (mean age 31.06 ± 10.26 years), which underwent chemotherapy (mean 2.47 cycles ± 0.5) were enrolled in this study. Odor threshold, discrimination and identification were assessed by means of the "Sniffin' Sticks" prior to and on day 42, 90 and 180 after chemotherapy has been completed. Furthermore, patients' ratings of olfactory function and depressive symptoms were evaluated. Threshold scores were significantly lower on day 90 (8.0 ± 2.51) compared to baseline (10.4 ± 2.20) (p = 0.014) and recovered almost completely on day 180 (9.65 ± 3.26). Odor discrimination and identification did not show significant changes during therapy. The decrease of the olfactory function during/immediately after chemotherapy was underlined by the subjectively perceived impaired olfactory function during this time. In addition almost every fourth patient presented with a depressed mood at the beginning of chemotherapy. Patients should be informed about possible transient olfactory impairment during/immediately after chemotherapy.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 49%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Testicular cancer patients undergoing cisplatin based chemotherapy exhibit temporary olfactory threshold scores changes

Walliczek‐Dworschak

Gudziol

Mitzschke

et al. 2017

Eur Arch Otorhinolaryngol

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“…For example, it has been demonstrated by numerous laboratories that alterations in chemosensory function in cancer patients predict dietary intake patterns, as well as quality of life (e.g., 9,21). The use of radiation and/or cytotoxic agents to combat the cancer is thought to be the major cause of taste dysfunction in cancer patients (17,18,31,64,73) via influences on taste bud cell survival, replacement, and proliferation (3,44,45,48). Collectively, these data provide powerful support for the role of taste in maintaining eating habits and quality of life.…”

Section: Perspectives and Significancementioning

confidence: 99%

The consequences of gustatory deafferentation on body mass and feeding patterns in the rat

Dotson

Colbert

Garcea

et al. 2012

American Journal of Physiology-Regulatory, Integrative and Comp

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Dotson CD, Colbert CL, Garcea M, Smith JC, Spector AC. The consequences of gustatory deafferentation on body mass and feeding patterns in the rat. Am J Physiol Regul Integr Comp Physiol 303: R611-R623, 2012. First published July 11, 2012 doi:10.1152/ajpregu.00633.2011.-The contribution of orosensory signals, especially taste, on body mass, and feeding and drinking patterns in the rat was examined. Gustatory deafferentation was produced by bilateral transection of the chorda tympani, glossopharyngeal, and greater superficial petrosal nerves. Total calories consumed from sweetened-milk diet and oil-chow mash by the nerve-transected rats significantly decreased relative to shamoperated controls, mostly attributable to decreases in bout number, but not size. Nevertheless, caloric intake steadily increased over the postsurgical observation period, but body mass remained below both presurgical baseline and control levels and did not significantly increase over this time. After the sweetened-milk diet/oil-chow mash phase, rats received a series of sucrose preference tests. Interestingly, the nerve-transected rats preferred sucrose, and intake did not differ from controls, likely due to the stimulus sharing some nontaste chemosensory properties with the sweetened-milk diet. The neurotomized rats initiated a greater number of sucrose-licking bouts that were smaller in size and slower in licking rate, compared with control rats, and, unlike in control rats, the latter two bout parameters did not vary across concentration. Thus, in the absence of gustatory neural input, body mass is more stable compared with the progressive trajectory of weight gain seen in intact rats, and caloric intake initially decreases but recovers. The consequences of gustatory neurotomy on processes that determine meal initiation (bout number) and meal termination (bout size) are not fixed and appear to be influenced by presurgical experience with food stimuli coupled with its nongustatory chemosensory properties. ageusia; body mass regulation; taste loss; taste nerves DECADES OF RESEARCH HAVE SHOWN that nutritional intake contributes to the development of human disease mainly by influencing the development of obesity and its associated conditions (e.g., cardiovascular disease, hypertension, Type 2 diabetes mellitus) [e.g., (8,28,35)]. Collectively, these studies suggest that a majority of obesity-related diseases could be prevented by the adoption of healthier eating habits. In the act of feeding, specialized chemosensory, thermosensory, and mechanosensory receptors, positioned in the nasal and oropharyngeal cavities, provide information to the brain related to the macronutrient composition, caloric density, osmolarity, and potential toxicity of food ingested (1,43,49,76). Chief among these neural signals are those provided by the gustatory system, which is the final guardian of the alimentary tract and provides a chemical analysis of stimulus components that do not typically have sufficiently high vapor pressures to effectively stimulate olfacto...

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Influence of Toxins on Olfactory Function and their Potential Association with Neurodegenerative Disease

Calderón‐Garcidueñas

2015

Handbook of Olfaction and Gustation

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Effect of platinum-containing chemotherapy on olfactory, gustatory, and hearing function in ovarian cancer patients

Cited by 23 publications

References 23 publications

Testicular cancer patients undergoing cisplatin based chemotherapy exhibit temporary olfactory threshold scores changes

Testicular cancer patients undergoing cisplatin based chemotherapy exhibit temporary olfactory threshold scores changes

The consequences of gustatory deafferentation on body mass and feeding patterns in the rat

Influence of Toxins on Olfactory Function and their Potential Association with Neurodegenerative Disease

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