Effect of platelet-rich plasma on healing in laser pilonidoplasty for pilonidal sinus disease

Kurt, Feyzi; Sözen, Selim; Kanat, Burhan Hakan; Kutluer, Nizamettin; Sakalli, Onur; Gencturk, Mehmet; Kanat, Zekiye

doi:10.1007/s10103-020-03137-5

Cited by 4 publications

(19 citation statements)

References 28 publications

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“…Both of these studies demonstrated a significant decrease in healing time for PRP‐treated wounds following surgery (Table 3). Neither study which reported post‐operative return to work time showed any significant difference between treatment arms [29, 34]. Complications including infection and recurrence were also similar between both groups (Table 3).…”

Section: Resultsmentioning

confidence: 89%

“…A total of 37 studies were identified and nine met the inclusion criteria (Tables 2 & 3); the included studies originated from Greece [26], Iran [27–29], Russia [30], Egypt [31] and Turkey [32–34] and were conducted between 2009 and 2021. Eight included studies were RCT's [26–33], and one was a case control study by Kurt et al [34], and all studies compared PRP treated wounds to dressings alone (Tables 2, 3).…”

Section: Resultsmentioning

confidence: 99%

“…Five studies investigated the use of PRP in open pilonidal surgery [26–28, 30, 31], three in minimally invasive pilonidal surgery [29, 33, 34], and one study reported patients in both groups [32]. A total of 621 and 309 patients were included in the open and minimally invasive groups, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…The four included studies in the minimally invasive group utilized a number of surgical approaches including: laser [34], curettage [32, 33] and excision + primary closure [29] (Table 3). In lieu of this methodological heterogeneity, it was decided to perform a narrative review of these studies.…”

Section: Resultsmentioning

confidence: 99%

“…All three studies in the open surgery group showed a significant reduction in time off work following application of PRP, with pooled analysis estimating a quicker return to work by over one week [26, 27, 31]. In contrast, neither study from the minimally invasive group demonstrated any recovery benefit from application of PRP; this may be due to a sub‐therapeutic concentration of PRP reaching the target tissue due to a lower wound surface area and/or only one opportunity for PRP application [29, 34].…”

Section: Discussionmentioning

confidence: 99%

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Platelet‐Rich Plasma (PRP) for Sacrococcygeal Pilonidal Disease: An Updated Systematic Review and Meta‐Analysis

2022

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Background Pilonidal disease can be a debilitating condition which carries a significant physical and economic burden. This systematic review and updated meta‐analysis presents the evidence for the use of platelet‐rich plasma (PRP) for wound healing following open and minimally‐invasive sacrococcygeal pilonidal surgery. Methods A literature search was performed during December 2021 for studies relating to platelet‐rich plasma and pilonidal wound healing following surgery. Results Nine studies remained after applying the exclusion criteria, incorporating a total of 621 (open surgery group) and 309 (minimally‐invasive group) patients, respectively. Pooled analysis of the six open surgery group studies demonstrated a significant reduction in wound healing time (mean difference [MD] = − 13.98 days, 95% CI − 18.41 to − 9.55, p < 0.001, I2 = 98%). Three open surgery group studies compared post‐operative time off work, while three recorded mean pain duration; pooled analysis also revealed a significant reduction in both outcomes, respectively (MD = − 8.7 days, 95% CI − 9.4 to − 8.0, p < 0.001, I2 = 57%; MD = − 9.5 days, 95% CI − 15.6 to − 3.3, p = 0.002, I2 = 98%). Methodological heterogeneity among the minimally‐invasive studies precluded formal meta‐analysis; however, two studies demonstrated a modest improvement in wound healing when treated with PRP. Conclusions This systematic review and updated meta‐analysis provide further evidence supporting the use of PRP for wound healing in sacrococcygeal pilonidal disease. PRP application was demonstrated to significantly reduce healing time, postoperative pain and time off work in the open surgery group. Nevertheless, there is still considerable heterogeneity among PRP manufacture and administration techniques, and further high‐powered RCTs with consistent methodology are required to substantiate these findings.

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Section: Resultsmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Platelet‐Rich Plasma (PRP) for Sacrococcygeal Pilonidal Disease: An Updated Systematic Review and Meta‐Analysis

2022

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Laser ablation: a unique and beneficial therapeutic option for pilonidal sinus? And the potential for further innovation—a review

Ganduboina,

Sreekumar,

Dutta

et al. 2023

Lasers Med Sci

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Platelet-rich plasma for pilonidal disease: a systematic review

Zhuang,

Feng

2023

J Int Med Res

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Objective To examine the use of platelet-rich plasma (PRP) for treatment of pilonidal disease (PD) and thus provide a reference for clinical application. Methods A systematic review of PubMed and the Cochrane Library was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. We considered all studies that reported the use of PRP for treatment of PD. Extracted data included the first author’s name, year of publication, study type, number of included patients, inclusion and exclusion criteria, interventions, anesthesia, application of PRP (source, preparation, dose, and operation), antibiotics, follow-up time, therapeutic outcomes, and adverse events. Results In total, eight randomized controlled trials and one prospective cohort study involving 809 patients were included. PRP reduced pain, accelerated healing, and reduced adverse events. The application of combined minimally invasive surgery achieved better results. However, overfilling of the wound with PRP in minimally invasive surgeries was shown to potentially increase the risk of adverse events. Conclusion PRP can be used as an adjuvant treatment in PD surgery to improve the therapeutic effect and reduce adverse events. The optimal combination of PRP and various factors is an important direction of future research. INPLASY registration number: INPLASY2023100070.

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Effect of platelet-rich plasma on healing in laser pilonidoplasty for pilonidal sinus disease

Cited by 4 publications

References 28 publications

Platelet‐Rich Plasma (PRP) for Sacrococcygeal Pilonidal Disease: An Updated Systematic Review and Meta‐Analysis

Platelet‐Rich Plasma (PRP) for Sacrococcygeal Pilonidal Disease: An Updated Systematic Review and Meta‐Analysis

Laser ablation: a unique and beneficial therapeutic option for pilonidal sinus? And the potential for further innovation—a review

Platelet-rich plasma for pilonidal disease: a systematic review

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