Effect of platelet‐rich plasma on bone regeneration in dentistry: a systematic review

Abstract

We found evidence for beneficial effects of PRP in the treatment of periodontal defects. Evidence for beneficial effects of PRP in sinus elevation appeared to be weak. No conclusions can be drawn about other applications of PRP in dentistry.

Maxillary sinus lift with solely autogenous bone compared to a combination of autogenous bone and growth factors or (solely) bone substitutes. A systematic review

“…Authors who did not describe randomization clearly were contacted via e-mail for additional information. When a proper randomization procedure was applied, these studies were added to the results 1,11,21,28 .…”

New bone formation using fibrin rich block with concentrated growth factors in maxillary sinus augmentation

“…최근 여러 연구에서는 환자의 혈액에서 유도된 물질을 골 이식의 보조제 및 대체재로 사용하고 있다 [17][18][19][20][21][22] . 환자의 정맥혈을 항응고제를 처리한 튜브에 넣고 원심분리하여 만든 platelet rich plasma (PRP)나 platelet rich growth factor (PRGF) 등은 골 이식재와 함께 상악동 거상술에 사용시 골 유도능이 있어 골 재생을 촉진한다는 연구가 있지만, 항응 고제의 첨가로 인한 그 성능에 이론의 여지가 있고 제작 과 정이 복잡하다는 단점이 있다 17,18 .…”

“…환자의 정맥혈을 항응고제를 처리한 튜브에 넣고 원심분리하여 만든 platelet rich plasma (PRP)나 platelet rich growth factor (PRGF) 등은 골 이식재와 함께 상악동 거상술에 사용시 골 유도능이 있어 골 재생을 촉진한다는 연구가 있지만, 항응 고제의 첨가로 인한 그 성능에 이론의 여지가 있고 제작 과 정이 복잡하다는 단점이 있다 17,18 . 이들보다 발전한 형태인 platelet rich fibrin (PRF)은 항응고제의 첨가 없이 원심분리 를 통하여 쉽게 얻을 수 있다.…”

Evaluation of the Effect of Platelet-Rich Plasma on Alveolar Wound Healing in Rats

“…However, opinions of the clinical utility of PRP vary (Sánchez et al, 2003;Gürbüzer et al, 2008) as a large number of experimental studies have questioned its efficacy (Gerard et al, 2006;Mooren et al, 2007;Plachokova et al, 2008;Oliveira Filho et al, 2010). On the other hand, the properties of PRP are promising, and further studies are warranted.…”

“…The effects of PRP on bone and soft-tissue healing have been related to an increased quantity of growth factors, such as platelet-derived growth factor (PDGF), transforming growth factor-β (TGF-β), vascular endothelial growth factor (VEGF), epithelial growth factor (EGF), insulin growth factor-I (IGF-I) and basic fibroblast growth factor (βFGF), being delivered to the surgical area (Weibrich et al, 2002;Plachokova et al). PDGF is believed to stimulate the proliferation of fibroblasts in the periodontal ligament and their migration into a clot, while TGF-β may be important in the differentiation of fibroblasts into osteoblasts, inducing these osteoprogenitor cells in the residual periodontal ligament to contribute to bone regeneration following tooth extraction (Devlin & Sloan, 2002).…”