Effect of Platelet-Rich Plasma on Peri-Implant Bone Repair: A Histologic Study in Dogs

Garcia, Ricardo Vieira; Gabrielli, Marisa Aparecida Cabrini; Hochuli‐Vieira, Eduardo; Spolidorio, Luís Carlos; Filho, J.G. Padilha; Neto, F.A. Doria; Cardoso, Luciana A. Gouveia de; Shibli, Jamil Awad

doi:10.1563/aaid-joi-d-09-00056

Cited by 28 publications

(21 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings are in accordance with the results of the study by the authors, Peev S et al, [19] in which improved stability of immediate loaded implants in the period between second and sixth week of their loading were observed with application of PRP. A significant change in bone levels was observed from baseline to one month and three months, so, effect of PRP on bone formation was found to be non-significant, these results contradict the results of the study by authors Anitua EA, [12] Anand U, [20] & Manimaran et al, [21] and are in accordance with the results of the study by Froum SJ et al, [22] Garcia RV et al, [23] and El -marssafy et al, [24] who suggested that PRP does not enhance bone formation around dental implants though they have used different types of implants in maxillary posterior areas. Similar implant stability was achieved with square and reverse buttress thread form implants.…”

Section: Discussionsupporting

confidence: 56%

Effect of Platelet-Rich-Plasma (PRP) and Implant Surface Topography on Implant Stability and Bone

Kundu

Rathee

2014

JCDR

View full text Add to dashboard Cite

Purpose: To evaluate the effect of Platelet-Rich-Plasma (PRP) and different implant surface topography on implant stability and bone levels around immediately loaded dental implants. Materials and Methods:Dental implants were placed in subjects divided into two groups and four subgroups on basis of implant treatment with PRP and implant surface topography used. A total of 30 implants were placed, 15 in each group. For PRP group, implants were placed after surface treatment with PRP. Temporization was done within two weeks and final prosthesis was given after three months. Implant stability was measured with Periotest at baseline, one month and three months. Bone height was measured on mesial & distal side on standardized IOPA x-rays.Results: A statistically significant difference was noticed in implant stability with PRP at baseline. The effect of PRP on bone height changes was not statistically significant. A synergistic effect of PRP and square thread-form was observed on improved implant stability and bone levels; however, no such effect is seen with PRP and reverse buttress thread-form. Conclusion:Within the limitation of this study, enhancement on implant stability and bone healing was observed with PRP treated implant surfaces, and with use of implant with square thread-form. InTROduCTIOnModern dentistry aims to restore the comfort and health of the stomatognathic system. Dental implants have emerged as a promising option for this purpose. Osseointegration forms the basis of implant success. Studies have been conducted to establish the criteria for success and failure of osseointegration and factors affecting osseointegration [1,2]. Traditionally, an unloaded healing period was considered essential for the achievement of osseointegration of dental implants [3]. Now in implant dentistry, advanced treatment protocols such as early or immediate loading are frequently used to reduce treatment time but this poses new demands on both the primary and secondary implant stability. Implant stability is defined as the capacity of the implant to withstand loading in axial, lateral, and rotational directions [4]. Primary stability is mainly dependent on the mechanical characteristics of the original bone like its local quality and quantity, the type of implant used including its geometry, diameter, length & surface characteristics, and the surgical techniques employed [5,6].Secondary implant stability represents enhancement of the stability as a result of peri-implant bone formation through gradual bone remodeling and osteoconduction, with the possibility of new bone formation at the implant-bone interface and influenced by the implant surface characteristics [7,8]. Contemporary knowledge indicates that the degree of micromotion at the bone-implant interface during initial healing is of utmost importance in achieving good secondary stability [9][10][11].Several measures have been proposed to improve and accelerate osseous healing of endosseous implants. Platelet-Rich-Plasma (PRP) has been suggested to enhance ...

show abstract

Section: Discussionsupporting

confidence: 56%

Effect of Platelet-Rich-Plasma (PRP) and Implant Surface Topography on Implant Stability and Bone

Kundu

Rathee

2014

JCDR

View full text Add to dashboard Cite

show abstract

“…Platelets are one of the first of the cellular mediators of the ensuing repair process to reach the implant site where the platelets attach to adsorbed adhesion proteins such as fibrinogen through their integrin α IIbβ3 surface receptor, thus forming a monolayer. This further activates the platelets to contract and release proteins contained within their α-granules 29) including growth factors such as PDGF, TGF-β1, TGF-β2, and IGF 30) . The subsequent use of platelet rich plasma (PRP) as a source of growth factors to enhance bone regeneration and osseointegration has been demonstrated in a number of studies however these results remain controversial in the light of more recent studies which failed to show any significant improvement in bone healing following pre-treatment with PRP 30) .…”

Section: Discussionmentioning

confidence: 99%

“…This further activates the platelets to contract and release proteins contained within their α-granules 29) including growth factors such as PDGF, TGF-β1, TGF-β2, and IGF 30) . The subsequent use of platelet rich plasma (PRP) as a source of growth factors to enhance bone regeneration and osseointegration has been demonstrated in a number of studies however these results remain controversial in the light of more recent studies which failed to show any significant improvement in bone healing following pre-treatment with PRP 30) . Notwithstanding these results, platelet-released proteins also elicit the initial cellular responses from fibroblasts, endothelial cells, neutrophils and macrophages.…”

Section: Discussionmentioning

confidence: 99%

Titanium surface hydrophilicity enhances platelet activation

2014

View full text Add to dashboard Cite

Titanium implant surface modification is a key strategy used to enhance osseointegration. Platelets are the first cells that interact with the implant surface whereupon they release a wide array of proteins that influence the subsequent healing process. This study therefore investigated the effect of titanium surface modification on the attachment and activation of human platelets. The surface characteristics of three titanium surfaces: smooth (SMO), micro-rough (SLA) and hydrophilic micro-rough (SLActive) and the subsequent attachment and activation of platelets following exposure to these surfaces were determined. The SLActive surface showed the presence of significant nanoscale topographical features. While attached platelets appeared to be morphologically similar, significantly fewer platelets attached to the SLActive surface compared to both the SMO and SLA surfaces. The SLActive surface however induced the release of the higher levels of chemokines β-thromboglobulin and platelet factor 4 from platelets. This study shows that titanium surface topography and chemistry have a significant effect on platelet activation and chemokine release.

show abstract

“…(Carl, 2007;Malik et al, 2011;Palwinder, 2011) The scientific basis for this success is the occurrence of osseointegrated dental implants with bone and patient clinical conditions that include adequate quality and quantity of bone. (Garcia, 2010) Hence, the authors are interested to see the value of post-placement BIC dental implant coated and not coated with PRP.…”

Section: Introductionmentioning

confidence: 99%

Differences of Post-Placement Bone Implant Contact (BIC) Value of Dental Implant Coated and Not Coated With Platelet Rich Plasma (PRP)

Thalib¹,

Machmud²,

Dharmautama³

et al. 2017

GJHS

View full text Add to dashboard Cite

show abstract

Effect of Platelet-Rich Plasma on Peri-Implant Bone Repair: A Histologic Study in Dogs

Cited by 28 publications

References 32 publications

Effect of Platelet-Rich-Plasma (PRP) and Implant Surface Topography on Implant Stability and Bone

Effect of Platelet-Rich-Plasma (PRP) and Implant Surface Topography on Implant Stability and Bone

Titanium surface hydrophilicity enhances platelet activation

Differences of Post-Placement Bone Implant Contact (BIC) Value of Dental Implant Coated and Not Coated With Platelet Rich Plasma (PRP)

Contact Info

Product

Resources

About