Effect of Platelet Rich Fibrin as an Adjunct to Bioactive Glass Compared to Bioactive Glass Alone for the Treatment of Intrabony Defects in Chronic Periodontitis Patients - A Systematic Review

Abstract

Background: Platelets are the richest source for cytokine and growth factors which are two important components of regeneration and Platelet Rich Fibrin (PRF) has gained popularity in the past two decades. PRF and bioactive glass (BG) have shown effective results in the reduction of Probing pocket depth (PPD), Gain in clinical attachment level (CAL) and defect ll in intrabony defects. Materials and Methods: Electronic searches were performed in PubMed, MEDLINE, Cochrane Library, Google Scholar and EbscoHost for the identication of relevant studies, till 30 September 2020 in English language. Additionally, hand search was also carried out in the relevant journals. The review protocol followed the PRISMA guidelines and was registered in PROSPERO (CRD42020211755). The risk of bias of the studies was independently evaluated using Cochrane Risk of Bias tool. Results: Five RCTs were included, which investigated the effects of PRF as an adjunct to bioactive glass comparing with Bioactive glass alone in the treatment of intrabony defects. In all the included studies it was found that PRF as adjunct had better results in the outcomes measured when compared with Bioactive glass alone. Conclusion: The current review has shown evidence suggesting that platelet rich brin can prove to be effective as a regenerative material, for the treatment of intrabony defects, in combination with bioactive glass.