Effect of platelet-poor plasma additive on the formation of biocompatible calcium phosphates

Глазов, И. Е.; Крутько, В. К.; Кулак, А. И.; Musskaya, O. N.; Власов, Р. А.; Malakhovsky, Pavel; Kumar, Vinit; Surya, Parthasarathy; Sridhar, Santosh Mysore; Reddy, Narendra

doi:10.1016/j.mtcomm.2021.102224

Cited by 9 publications

(12 citation statements)

References 60 publications

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“…The dissolution curves of the powdered samples were assessed by examining their evolution in a model Simulated Body Fluid (SBF) solution with pH of 7.2 and ion concentrations identical to those in human blood plasma [ 26 ]. The SBF solution was prepared in accordance with our previous study [ 21 ], using analytical grade reagents (Sigma Aldrich, St. Louis, MO, USA) except for hydrochloric acid, which was prepared from fixanal (vacuum sealed ampoule, AnalysX, Minsk, Belarus). The powdered samples (150 ± 10 mg) were soaked in 50 mL of the SBF solution for 75 days, measuring the supernatant pH value every 7 days.…”

Section: Methodsmentioning

confidence: 99%

“…However, there are few data on the effect of blood components on the phase composition of precipitated calcium phosphates, even though phase composition is among the properties that strongly affect the material resorbability. According to our previous study [ 21 ], the addition of 6% PPP in the precipitation medium brings about the formation of bioactive calcium phosphate composites instead of single-phased stoichiometric HAp. Developing this idea, we decided to expand the range of utilized PPP concentrations and to vary the duration of HAp maturation under the mother solution.…”

Section: Introductionmentioning

confidence: 99%

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Formation of Hydroxyapatite-Based Hybrid Materials in the Presence of Platelet-Poor Plasma Additive

et al. 2023

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Biomaterials based on hydroxyapatite with controllable composition and properties are promising in the field of regenerative bone replacement. One approach to regulate the phase composition of the materials is the introduction of biopolymer-based additives into the synthesis process. The purpose of present study was to investigate the formation of hydroxyapatite-based hybrid materials in the presence of 6–24% platelet-poor plasma (PPP) additive, at a [Ca2+]/[PO43−] ratio of 1.67, pH 11, and varying maturing time from 4 to 9 days. The mineral component of the materials comprised 53% hydroxyapatite/47% amorphous calcium phosphate after 4 days of maturation and 100% hydroxyapatite after 9 days of maturation. Varying the PPP content between 6% and 24% brought about the formation of materials with rather defined contents of amorphous calcium phosphate and biopolymer component and the desired morphology, ranging from typical apatitic conglomerates to hybrid apatite-biopolymer fibers. The co-precipitated hybrid materials based on hydroxyapatite, amorphous calcium phosphate, and PPP additive exhibited increased solubility in SBF solution, which defines their applicability for repairing rhinoplastic defects.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Formation of Hydroxyapatite-Based Hybrid Materials in the Presence of Platelet-Poor Plasma Additive

et al. 2023

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“…Проведенные нами исследования [19,20] доказали эффективность применения композитов ГА/аутофибрин в риносептопластике. В наших предыдущих работах [21,22] описаны физикохимические свойства композитов на основе ГА, осажденных в среде аутофибрина при pH 11. Установлено [22], что присутствие добавки биополимера в среде осаждения ГА с pH 11 способствует стабилизации включений АФК и отклонению состава ГА от стехиометрического [10].…”

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“…В наших предыдущих работах [21,22] описаны физикохимические свойства композитов на основе ГА, осажденных в среде аутофибрина при pH 11. Установлено [22], что присутствие добавки биополимера в среде осаждения ГА с pH 11 способствует стабилизации включений АФК и отклонению состава ГА от стехиометрического [10]. Однако выдерживание образцов в сильнощелочной среде формирования стехиометрического ГА сопровождалось частичным разрушением аутофибрина.…”

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“…Результаты исследований и их обсуждение. Известно [22], что в сильнощелочной среде с pH 11 фибриновый сгусток неустойчив и растворяется в течение суток, а при pH 9 время растворения фибрина составляет 14 сут, что обеспечивает сохранение биополимерной матрицы в композитах. Осаждение ТКФ в матрице цитратной плазмы сопровождалось схватыванием осадка за счет формирования фибриновой сетки в объеме реакционной смеси [21].…”

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Nanocomposites based on apatitic tricalcium phosphate and autofibrin

Глазов

Крутько

Власов

et al. 2021

Vescì Akademìì navuk Belarusì. Seryâ himičnyh navuk

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Nanocomposites based on apatitic tricalcium phosphate in an autofibrin matrix were obtained by precipitation at a Ca/P ratio of 1.50, pH 9 and a maturation time from 30 min to 7–14 days. The resorbability of nanocomposites was determined by the composition of calcium phosphates, which, during long-term maturation, formed as the calcium-deficient hydroxyapatite with a Ca/P ratio of 1.66, whereas biopolymer matrix favored the formation of more soluble calcium phosphates with a Ca/P ratio of 1.53–1.59. It was found that the fibrin clot stabilized, along with apatitic tricalcium phosphate, the phase of amorphous calcium phosphate, which after 800 °C was transformed into resorbable α-tricalcium phosphate. Citrated plasma inhibited the conversion of apatitic tricalcium phosphate into stoichiometric hydroxyapatite, which also facilitated the formation of resorbable β-tricalcium phosphate after 800 °C. The combined effect of the maturation time and the biopolymer matrix determined the composition, physicochemical and morphological properties of nanocomposites and the possibililty to control its extent of resorption

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Modifications in the Surface of Titanium Substrate and the Incorporation of an Essential Oil for Biomaterial Application

Ferreira

Sousa

Barboza

et al. 2022

J. of Materi Eng and Perform

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Effect of platelet-poor plasma additive on the formation of biocompatible calcium phosphates

Cited by 9 publications

References 60 publications

Formation of Hydroxyapatite-Based Hybrid Materials in the Presence of Platelet-Poor Plasma Additive

Formation of Hydroxyapatite-Based Hybrid Materials in the Presence of Platelet-Poor Plasma Additive

Nanocomposites based on apatitic tricalcium phosphate and autofibrin

Modifications in the Surface of Titanium Substrate and the Incorporation of an Essential Oil for Biomaterial Application

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