Effect of plasma metabolites of (+)-catechin and quercetin on monocyte adhesion to human aortic endothelial cells

Koga, Takuro; Meydani, Mohsen

doi:10.1093/ajcn/73.5.941

Cited by 146 publications

(104 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has also been suggested that conjugation and methylation of the phenolic moiety led to a decrease in its antioxidative activity, via the suppression of scavenging chain-initiating oxygen radicals or chelating transition metal ions (Nanjo et al, 1996;Rice-Evans et al, 1996). On the other hand, Baba et al (2000) and Koga and Meydani (2001) reported that various conjugated forms of catechin enhanced antioxidative activity. Consequently, it is not clear whether free or conjugated catechins are more effective at enhancing antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

The relation between single/double or repeated tea catechin ingestions and plasma antioxidant activity in humans

et al. 2002

View full text Add to dashboard Cite

Objective: The purpose of this study was to investigate the effects of single=double or repeated intake of a normal amount of tea catechin on plasma catechin concentrations and antioxidant activity in young women. Design: First, after an overnight fast, five healthy subjects were given water or single=double dose(s) of tea polyphenol extract (164 mg tea catechins containing 61% epigallocatechin gallate in 190 ml water). Blood samples were taken before and 30, 60 and 180 min after the ingestion. Second, 16 healthy subjects ingested the tea polyphenol extract three times a day at mealtimes for 7 days followed by withdrawal of tea polyphenol extract for 7 days. Blood samples were taken before and after ingestion, and 7 days after the withdrawal of tea catechin. Subjects were prohibited from drinking any beverages containing polyphenols or antioxidant supplements during the study period. Catechin and other antioxidant concentrations in the plasma were measured, and changes in antioxidant activity were evaluated by ferric reducing ability of plasma assay. Results: Single=double ingestion of tea polyphenol extract did not cause an increase in the antioxidant activity. There was no also change in antioxidant activity after the ingestion of tea polyphenol extract for 7 days. Plasma-free epigallocatechin gallate concentration remained at the pre-study level; however, the plasma FRAP value decreased significantly at 7 days after the withdrawal of tea polyphenol extract. Decreases in endogenous antioxidants in the plasma, including vitamin C and bilirubin, were also observed 7 days after withdrawal of tea polyphenol. Conclusions:The results suggest that continuous daily intake of tea catechins affects the concentrations of endogenous antioxidants in the plasma and has the potential to maintain total antioxidant activity.

show abstract

Section: Discussionmentioning

confidence: 99%

The relation between single/double or repeated tea catechin ingestions and plasma antioxidant activity in humans

et al. 2002

View full text Add to dashboard Cite

show abstract

“…For example, red wine and polyphenols inhibit activation of nuclear factor-kB and production of proinflammatory factors in endothelial cells and inflammatory cells (61,68). Incubation of monocytes with catechin decreased their adhesion to endothelial cells (69). Relevant polyphenols also inhibit activation of nuclear factor-kB in T lymphocyte cell lines (70).…”

Section: Epidemiologymentioning

confidence: 99%

Grapes and Cardiovascular Disease

Dohadwala

Vita

2009

The Journal of Nutrition

176

View full text Add to dashboard Cite

Epidemiological studies suggest that consumption of wine, grape products, and other foods containing polyphenols is associated with decreased risk for cardiovascular disease. The benefits of wine consumption appear to be greater than other alcoholic beverages. Experimental studies indicate that grape polyphenols could reduce atherosclerosis by a number of mechanisms, including inhibition of oxidation of LDL and other favorable effects on cellular redox state, improvement of endothelial function, lowering blood pressure, inhibition of platelet aggregation, reducing inflammation, and activating novel proteins that prevent cell senescence, e.g. Sirtuin 1. Translational studies in humans support these beneficial effects. More clinical studies are needed to confirm these effects and formulate dietary guidelines. The available data, however, strongly support the recommendation that a diet rich in fruits and vegetables, including grapes, can decrease the risk for cardiovascular disease.

show abstract

“…Only a very few investigators have studied the influence of metabolism on the bioactivity of flavonoids [105,137,178,193,194], thus most of the effects reported based on in vitro experiments, cannot be extrapolated to in vivo situations. For example, one of the most intensively investigated flavonoids, quercetin, is often just used as the aglycone in cell culture systems and interesting biological activities such as modulation of the multidrug-resistance protein [118], induction of apoptosis [168], inhibition of the expression of nitric oxide synthase and cyclooxygenase [162], protection against oxidative stress [88] and modulation of the calcium homeostasis [209] have been reported.…”

Section: Flavonoids: Neuroprotective Agents In Vivo and In Vitro?mentioning

confidence: 99%

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

Schroeter

Boyd

Spencer

et al. 2002

Neurobiology of Aging

302

178

View full text Add to dashboard Cite

Oxidative and nitrosative stress is increasingly associated with the pathology of neurodegeneration and aging. The molecular mechanisms underlying oxidative/nitrosative stress-induced neuronal damage are emerging and appear to involve a mode of death in which mitogen-activated protein kinase (MAPK) signaling pathways are strongly implicated. Thus, attention is turning towards the modulation of intracellular signaling as a therapeutic approach against neurodegeneration. Both endogenous and dietary agents have been suggested as potent modulators of intracellular signal transduction, e.g. nitric oxide and flavonoids, respectively. This review addresses recent findings on the biological effects of flavonoids and nitric oxide in neurodegeneration and aims to elucidate the rationale for their prospective use as modulators of cellular signal transduction. © 2002 Elsevier Science Inc. All rights reserved.Keywords: Apoptosis; Oxidative stress; Neuron; Flavonoids; MAP kinase; JNK; ERK; Epicatechin; Nitric oxide; Mitochondria; Redox status; Polyphenols Abbreviations: AKT, serine/threonine kinase (also known as protein kinase B); AP-1, activator protein-1; Apaf-1, apoptosis protease activating factor-1; ASK1, apoptosis signal-regulating kinase-1; Bad, Bcl-2/BclX Lassociated death promoting protein; Bax, pro-apoptotic protein of the Bcl-2 family; Bcl-2, B-cell lymphoma 2: protein with anti-apoptotic properties; BclX L , long form of Bclx: anti-apoptotic protein of the Bcl-2 family; Caspase, cysteinyl aspartic acid-protease; c-Jun, mammalian equivalent of Jun: part of the AP-1 transcription complex; CREB, cAMP response element binding protein; DIABLO/smac, mitochondria-related pro-apoptotic protein: inhibits XIAP; ERK1/2, extracellular signal-related kinase; Fas, CD95: member of the TNF receptor family; GSHST, glutathione Stransferase; JNK, c-Jun amino-terminal kinase; MAPK, mitogen-activated protein kinase; MAPKK, MAPK kinase; MAPKKK, MAPKK kinase; MEK1/2, ERK1/2-specific MAPKK; MKK4/7, JNK-specific MAPKK; MSK1, mitogen-and stress-activated kinase-1; NF-B, nuclear factor of immunoglobulin k locus in B-cells; ONOO − , peroxynitrite anion; p53, pro-apoptotic tumor suppressor gene product; PI3-kinase, phosphoinositol 3-kinase; Ras, small G-protein; RNS, reactive nitrogen species; ROS, reactive oxygen species; RSK, pp90 ribosomal S6 kinase; SAPK, stressactivated protein kinase; XIAP, X-linked inhibitor of apoptosis: inhibits the activation of caspase-9

show abstract

Effect of plasma metabolites of (+)-catechin and quercetin on monocyte adhesion to human aortic endothelial cells

Abstract: Metabolic conversion of flavonoids such as (+)-catechin and quercetin modifies the flavonoids' biological activity. Metabolites of flavonoids, rather than their intact forms, may contribute to the reported effects of flavonoids on reducing the risk of cardiovascular disease.

Cited by 146 publications

References 51 publications

The relation between single/double or repeated tea catechin ingestions and plasma antioxidant activity in humans

The relation between single/double or repeated tea catechin ingestions and plasma antioxidant activity in humans

Grapes and Cardiovascular Disease

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

Contact Info

Product

Resources

About