Effect of Plasma from Premenstrual Syndrome and Control Patients on Human Platelet and Rat Brain Synaptosome Monoamine Oxidase B Activity

Ashby, Charles R.; Carr, Laurence A.; Cook, Christine L.; Steptoe, Margaret M.; Franks, Darrell D.

doi:10.1159/000118820

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…Furthermore, approximately 50% of females have experienced physical/mental discomfort or premenstrual syndrome between ovulation and the start of menstruation. In those with depression, there was a correlation between the severity of mental symptoms and that of physical symptoms 6. Thus, the subjective assessment of depression-related mental discomfort, as well as the objective assessment of a stress-related reduction in female hormone secretion, must be considered.…”

Section: Introductionmentioning

confidence: 99%

Relationships between Salivary Melatonin Levels, Quality of Sleep, and Stress in Young Japanese Females

Ito

Iida

Teramura

et al. 2013

Int J�Tryptophan�Res

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A decrease in the quality of sleep is believed to cause anxiety and worsen depression. Comparisons of salivary melatonin levels with different factors including quality of sleep, state and trait anxieties, and depression, were conducted to examine whether there is a relationship between melatonin, presumably associated with sleep, and psychological stress. The saliva of healthy young females was collected during the daytime and before they went to bed at night (when they were awake and resting in a sitting position), and salivary melatonin levels were measured. The quality of sleep was scored using the Pittsburgh Sleep Quality Index (PSQI)—a questionnaire method. State and trait anxieties, and depression were scored using other questionnaire methods: the State-Trait Anxiety Inventory (STAI) and Self-Rating Depression Scale (SDS), respectively. The following findings were obtained: (1) Salivary melatonin levels measured during the daytime and before going to bed were higher in females with a high depression score, compared to those with a low score, and there was a correlation between the depression scores and salivary melatonin levels measured at night; and (2) salivary melatonin levels measured before going to bed at night (in a sitting position) were higher in females with a high state anxiety score, suggesting a correlation between state anxiety scores and salivary melatonin levels during the night. Both depression and a sense of anxiety are forms of psychological stress. Therefore, it is assumed that, when a person is under psychological stress, the action of melatonin as a ligand on its receptor is reduced. Meaning psychological stress may induce oxidative stress in the body. On the other hand, no correlation was noted between the quality of sleep and salivary melatonin levels during the night, presumably because saliva was collected when the subjects were awake and sitting, rather than sleeping.

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Section: Introductionmentioning

confidence: 99%

Relationships between Salivary Melatonin Levels, Quality of Sleep, and Stress in Young Japanese Females

Ito

Iida

Teramura

et al. 2013

Int J�Tryptophan�Res

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Synthesis and Biological Screening of 2-Substituted 5,6-Dihydro-5-oxo- 4H-1,3,4-oxadiazine-4-propanenitriles and of Their Intermediates

Khan

Rahat

Choudhary

et al. 2002

HCA

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To evaluate the effect of substituents on biological activities of electron-rich N-containing heterocycles, the variably 2-substituted 5,6-dihydro-5-oxo-4H-1,3,4-oxadiazine-4-propanenitriles 26 ± 33 were synthesized and evaluated for antibacterial, antifungal, and enzyme-inhibition activities. The target compounds were obtained from alkyl 4-or 3-hydroxy benzoates 1 and 2, respectively, and from methyl indoleacetate 3. The phenolic OH group of benzoates 1 and 2 were substituted with p-toluenesulfonyl ( 3 4 and 5), benzoyl ( 3 6 and 7), and benzyl groups ( 3 8 and 9) and then converted to 5,6-dihydro-5-oxo-4H-1,3,4-oxadiazine-4-propanenitriles. To establish structure-activity relationships (SAR), a pharmacological screening of the intervening intermediates was also conducted, which revealed that the intermediate hydrazide 11 possesses significant antimicrobial and MAO-A inhibiting properties and intermediates 12, 24, 28, and 29 appreciable antifungal activities. Compound 7 inhibits a-chymotrypsin. Introduction. ± A diversity of biological effects is associated with 1,3,4-oxadiazine and its derivatives, they exhibit cardiovascular [1 ± 3], antibacterial [4], plant-growth regulating [5], miticidal and nematocidal [6], acricidal [7], and insecticidal activities [8]and monoamine-oxidase (MAO) inhibition [9]. The promising therapeutic potential of this class of compounds prompted us to synthesize and biologically screen a series of structural variants of 4H-1,3,4-oxidiazine-5(6H)-ones. To establish structure activity relationships (SAR), the activities of the intervening intermediates were also determined. Thus, the readily available alkyl benzoates 1, 2, and 4 ± 9 and the indoleacetate 3 were transformed to the target 5,6-dihydro-5-oxo-4H-1,3,4-oxadiazine-4-propanenitriles 26 ± 33 in excellent yields. The structures of 26 ± 33 were established by spectroscopic techniques, and their biological activities were determined.

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Behavioral and Biochemical Studies of Dichloromethane Fraction From the Areca catechu Nut

Dar

Khatoon

2000

Pharmacology Biochemistry and Behavior

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Effect of Plasma from Premenstrual Syndrome and Control Patients on Human Platelet and Rat Brain Synaptosome Monoamine Oxidase B Activity

Cited by 3 publications

References 12 publications

Relationships between Salivary Melatonin Levels, Quality of Sleep, and Stress in Young Japanese Females

Relationships between Salivary Melatonin Levels, Quality of Sleep, and Stress in Young Japanese Females

Synthesis and Biological Screening of 2-Substituted 5,6-Dihydro-5-oxo- 4H-1,3,4-oxadiazine-4-propanenitriles and of Their Intermediates

Behavioral and Biochemical Studies of Dichloromethane Fraction From the Areca catechu Nut

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