Effect of Plasma Calcium Concentration on the Metabolic Clearance Rate of Calcitonin in the Dog

Fox, Julie; Heath, Hunter

doi:10.1055/s-2007-1014690

Cited by 9 publications

(13 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The peripheral metabolism of PTH is rapid; intact PTH is cleared from the circulation with a half-time disappearance of 2-5 min [5,6] . The majority of PTH (60-70%) is cleared from the blood hepatically, with the remainder (20-30%) cleared by the kidney [7,8] .…”

Section: Parathyroid Hormone: Synthesis and Bioutilizationmentioning

confidence: 99%

The Role of Intraoperative Measurement of Parathyroid Hormone in Parathyroid Surgery

Pellitteri¹

2008

ORL

View full text Add to dashboard Cite

Technological developments have significantly contributed to the rapid evolution of the surgical management of parathyroid disorders. The ability to physiologically determine the intraoperative status of the patient is now possible through the assessment of changing levels of intact parathyroid hormone (PTH) during surgery. In most patients with primary hyperparathyroidism, this method provides biochemical confirmation of hyperfunctional gland removal, and is predictive of a eucalcemic state and surgical cure. Patients with renal-induced disease (excluding tertiary hyperparathyroidism) do not follow the same kinetic decline in PTH and are therefore less likely to benefit from this modality. An emerging population of patients with primary disease and lower baseline levels of intact PTH appear to demonstrate a greater likelihood of manifesting multiple gland disease and do not follow a consistently predictable kinetic degradation profile. Although this category of patients will require further investigation, potentially resulting in modification of the utility of intraoperative determination of PTH levels, it is clear that this modality represents a very powerful technique which has significantly enhanced the surgical treatment of parathyroid disease.

show abstract

Section: Parathyroid Hormone: Synthesis and Bioutilizationmentioning

confidence: 99%

The Role of Intraoperative Measurement of Parathyroid Hormone in Parathyroid Surgery

Pellitteri¹

2008

ORL

View full text Add to dashboard Cite

show abstract

“…However, it seems unlikely that CT meta bolic clearance is affected in hypercalcemia. In fact, it has been demonstrated that during both chronic and acute hypercalcemia in ani mals [11], the metabolic clearance rate for human calcitonin is normal and of the same orde of magnitude as reported for normal human subjects [12].…”

Section: Discussionmentioning

confidence: 77%

Basal and Stimulated Calcitonin Secretion in Primary Hyperparathyroidism before and after Parathyroidectomy

Tabolli¹,

Valtorta²,

Bigi³

et al. 1986

Horm Res

View full text Add to dashboard Cite

To investigate calcitonin secretion in primary hyperparathyroidism, basal and stimulated (3 mg Ca⁺⁺/kg body weight/10 min) immunoreactive calcitonin plasma levels were studied before parathyroidectomy. Plasma calcitonin levels were raised in 50% of patients regardless of sex, but a significant correlation between basal plasma calcium and calcitonin was found only in males. A reduced calcitonin response to calcium infusion was observed in all patients. Parathyroidectomy invariably induced a normalization of calcitonin basal levels. Our findings confirm the existence of a decreased parafollicular cell reserve probably as a consequence of the persistent hypercalcemic state in hyperparathyroid patients and suggest that it is more frequent in females.

show abstract

“…p-Ca 2ϩ might affect the peripheral metabolism of PTH (33)(34)(35). It was observed by our group in the isolated perfused liver Figure 4.…”

Section: Discussionmentioning

confidence: 81%

Parathyroid Hormone 7-84 Induces Hypocalcemia and Inhibits the Parathyroid Hormone 1-84 Secretory Response to Hypocalcemia in Rats with Intact Parathyroid Glands

Huan

Ølgaard

Nielsen

et al. 2006

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Biologic effects of large C-terminal parathyroid hormone (PTH) fragments, opposite to those of N-terminal PTH, have been demonstrated. C-terminal PTH fragments are co-secreted with N-terminal PTH from the parathyroids. The aim of our study was to examine whether C-terminal PTH 7-84 regulates secretion of PTH 1-84 and affects the expression of genes of relevance for parathyroid function, PTH, calcium-sensing receptor (CaR), PTH type 1 receptor (PTHR1), and PTH-related peptide (PTHrP) genes in rat parathyroid glands. PTH 7-84 induced a significant decrease in plasma Ca 2؉ in rats with intact parathyroid glands. Despite the reduction of plasma Ca 2؉ , no stimulation of PTH 1-84 secretion took place. Furthermore, the PTH 1-84 secretory response to EGTA-induced acute and severe hypocalcemia was significantly inhibited by PTH 7-84. During recovery from hypocalcemia, plasma Ca 2؉ levels were significantly lower in the PTH 7-84 -treated group, as compared with the vehicle group, and at the same time plasma PTH 1-84 levels were significantly suppressed. The expression of PTH, CaR, PTHR1, and PTHrP genes in the rat parathyroid glands was not affected by PTH 7-84. The peripheral metabolism of PTH 1-84 was not affected by PTH 7-84. PTH 7-84 did not cross-react with the rat bioactive PTH 1-84 assay. In normal rats with intact parathyroid glands, PTH 7-84 inhibited the PTH 1-84 secretory response to hypocalcemia and induced a significant decrease in plasma Ca 2؉ . These effects of PTH 7-84 on PTH 1-84 secretion and on plasma Ca 2؉ levels were not associated with significant changes in PTH, PTHR1, CaR, and PTHrP gene expressions in the rat parathyroid glands. It is hypothesized that PTH 7-84 regulates PTH secretion via an autocrine/paracrine regulatory mechanism.

show abstract

Effect of Plasma Calcium Concentration on the Metabolic Clearance Rate of Calcitonin in the Dog

Cited by 9 publications

References 11 publications

The Role of Intraoperative Measurement of Parathyroid Hormone in Parathyroid Surgery

The Role of Intraoperative Measurement of Parathyroid Hormone in Parathyroid Surgery

Basal and Stimulated Calcitonin Secretion in Primary Hyperparathyroidism before and after Parathyroidectomy

Parathyroid Hormone 7-84 Induces Hypocalcemia and Inhibits the Parathyroid Hormone 1-84 Secretory Response to Hypocalcemia in Rats with Intact Parathyroid Glands

Contact Info

Product

Resources

About