Effect of pirfenidone on pulmonary fibrosis due to paraquat poisoning in rats

Abstract

This study showed that pirfenidone is able to decrease pulmonary fibrosis following paraquat poisoning in a rat model.

The antioxidants dilemma: are they potentially immunosuppressants and carcinogens?

“…It has been shown that increased oxidative stress could enhance prevalence of malignancies by direct cellular damage, Seifirad et al (2012); Lu et al (2013); Seifirad and Masoudkabir (2013) however, as mentioned above oxidative stress when applied as immune system arms could protect organisms from invading pathogens and malignant cells (Weel et al, 1996). …”

CT imaging as a prognostic indicator for patients with pulmonary injury from acute paraquat poisoning

“…Immediate treatment with anti-oxidants (such as vitamins C and E), glucocorticoids, cytotoxic agents and certain forms of newly developed antifibrotic agents can improve the prognosis [10]. Only recently have radiological findings, such as CT scanning, been employed to examine the pulmonary effects and progression of acute PQ poisoning, revealing the highly variant response of individual patients to PQ.…”

The relation of radiation-induced pulmonary fibrosis with stress and the efficiency of antioxidant treatment: An experimental study

“…Vitamin C chromium-induced pulmonary fibrosis prevents pulmonary fibrosis in rats and its combination with vitamin E is more effective [28]. On the other hand, it was determined that vitamin C is not effective in preventing fibrosis created with paraquat [29]. It was shown that nonalcoholic steatohepatitis-related fibrosis decreases in patients when a vitamin C and vitamin E combination is applied compared to placebo.…”