Effect of piperlongumine during exposure to cigarette smoke reduces inflammation and lung injury

Sant’Ana, Monielle; Souza, Helena Ribeiro; Possebon, Lucas; Cornélio, Marinônio Lopes; Riffo‐Vasquez, Yanira; Girol, Ana Paula; Oliani, Sônia Maria

doi:10.1016/j.pupt.2020.101896

Cited by 14 publications

(13 citation statements)

References 46 publications

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“…Besides, PL prevented the airway remodeling in the mice models caused due to extracellular matrix degradation, by reducing expression levels of MMP-9, collagen deposition, elastase, etc. [ 298 ], [ 301 ] In the collagen-induced arthritis mice model, PL is shown to suppress the expression of TNF-α, IL-1β, IL-23, and IL-17 [ 292 ].…”

Section: Anti-inflammatory Role Of Spicesmentioning

confidence: 99%

COVID-19, cytokines, inflammation, and spices: How are they related?

et al. 2021

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Background Cytokine storm is the exaggerated immune response often observed in viral infections. It is also intimately linked with the progression of COVID-19 disease as well as associated complications and mortality. Therefore, targeting the cytokine storm might help in reducing COVID-19-associated health complications. The number of COVID-associated deaths (as of January 15, 2021; https://www.worldometers.info/coronavirus/ ) in the USA is high (1199/million) as compared to countries like India is low (110/million). Although the reason behind this is not clear, spices may have some role in explaining this difference. Spices and herbs are used in different traditional medicines, especially in countries such as India to treat various chronic diseases due to their potent antioxidant and anti-inflammatory properties. Aim To evaluate the literature available on the anti-inflammatory properties of some spices which might prove beneficial in the prevention and treatment of COVID-19 associated cytokine storm. Method A detailed literature search has been conducted on PubMed for collecting information pertaining to the COVID-19; the history, origin, key structural features, and mechanism of infection of SARS-CoV-2; the repurposed drugs in use for the management of COVID-19 and the anti-inflammatory role of spices to combat COVID-19 associated cytokine storm. Key findings The literature search resulted in numerous in vitro , in vivo and clinical trials that have reported the potency of spices to exert anti-inflammatory effects by regulating crucial molecular targets for inflammation. Significance As spices are derived from Mother Nature and are inexpensive, they are relatively safer to consume. Therefore, their anti-inflammatory property can be exploited to combat the cytokine storm in COVID-19 patients. This review thus focuses on the current knowledge on the role of spices for the treatment of COVID-19 through suppression of inflammation-linked cytokine storm.

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Section: Anti-inflammatory Role Of Spicesmentioning

confidence: 99%

COVID-19, cytokines, inflammation, and spices: How are they related?

et al. 2021

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“…Our investigations indicated that PL attenuated systemic and pulmonary inflammatory changes, partially by modulating the expression of the endogenous AnxA1, in lung inflammation induced by cigarette smoke [42]. The potential of PL as a therapeutic immunomodulator for cancer prevention and progression was reinforced by analyzing PL administration in human cancer cells from an epidermoid carcinoma of the larynx (Hep-2) and umbilical vein endothelial cells (HUVEC), in which PL modulated the expression of genes involved in inflammatory processes [36].…”

Section: Introductionmentioning

confidence: 86%

“…For the selection of the PL dosage and for the purpose of comparison with the peptide, we chose two dosages. The lowest dosage of 200 µg (1 mg/kg or 1.57 mM) was equal to the one used for the peptide, while the highest dosage was based on another investigation by our group, which tested the therapeutic efficacy of PL by ip administration at a dosage of 400 µg (2 mg/kg or 3.15 mM) diluted in 100 µL of 10% dimethyl sulfoxide (DMSO, Gold Lab; Ribeirão Preto, São Paulo, Brazil) [42].…”

Section: Experimental Model Of Uveitis and Treatment Protocolsmentioning

confidence: 99%

“…In recent years, another potent anti-inflammatory mediator, piperlongumine (PL) (5,6-dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)pyridinone), a biologically active component of Piper species (Piperaceae), has attracted the attention of our research group for its possible interaction with AnxA1 [36]. In particular, PL is the main alkaloid of long pepper (Piper longum L.), and its pharmacological actions include cytotoxic, antitumor, antiangiogenic, antiplatelet, antibacterial, antidiabetic, antianxiolytic, antiatherosclerotic, and antifungal effects [36][37][38][39][40][41][42][43]. PL induces apoptosis by interfering with redox and reactive oxygen species (ROS) homeostatic regulators, such as glutathione S-transferase pi 1 (GSTP1) and carbonyl reductase (CBR1) [44].…”

Section: Introductionmentioning

confidence: 99%

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Annexin A1 Mimetic Peptide and Piperlongumine: Anti-Inflammatory Profiles in Endotoxin-Induced Uveitis

Girol

Zanon

Caruso

et al. 2021

Cells

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Uveitis is one of the main causes of blindness worldwide, and therapeutic alternatives are worthy of study. We investigated the effects of piperlongumine (PL) and/or annexin A1 (AnxA1) mimetic peptide Ac2-26 on endotoxin-induced uveitis (EIU). Rats were inoculated with lipopolysaccharide (LPS) and intraperitoneally treated with Ac2-26 (200 µg), PL (200 and 400 µg), or Ac2-26 + PL after 15 min. Then, 24 h after LPS inoculation, leukocytes in aqueous humor, mononuclear cells, AnxA1, formyl peptide receptor (fpr)1, fpr2, and cyclooxygenase (COX)-2 were evaluated in the ocular tissues, along with inflammatory mediators in the blood and macerated supernatant. Decreased leukocyte influx, levels of inflammatory mediators, and COX-2 expression confirmed the anti-inflammatory actions of the peptide and pointed to the protective effects of PL at higher dosage. However, when PL and Ac2-26 were administered in combination, the inflammatory potential was lost. AnxA1 expression was elevated among groups treated with PL or Ac2-26 + PL but reduced after treatment with Ac2-26. Fpr2 expression was increased only in untreated EIU and Ac2-26 groups. The interaction between Ac2-26 and PL negatively affected the anti-inflammatory action of Ac2-26 or PL. We emphasize that the anti-inflammatory effects of PL can be used as a therapeutic strategy to protect against uveitis.

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“…Interestingly, a study demonstrated that PL exhibits the potential to suppress glycolysis via suppression of hexokinase activity [228]. It also reduces the glucose levels, influx of lymphocytes, macrophages, and neutrophils in BALF and attenuates both systemic and pulmonary inflammation [229]. A study reported that hypoxia condition can potentiate the activity of PL [230].…”

Section: Anti-inflammatory and Health Mediated Properties Of Piper Longummentioning

confidence: 99%

Phytotherapy for treatment of cytokine storm in COVID19

2021

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In 2020, a novel strain of coronavirus has led to a significant morbidity and mortality worldwide. As of the date of this writing, a total of 116 M cases has been diagnosed worldwide leading to 2.5 M deaths. The number of mortalities is directly correlated with the rise of innate immune cells (especially macrophages) in the lungs that secrete inflammatory cytokines (IL-1β and IL-6) leading to the development of "Cytokine Storm Syndrome" (CSS), multi-organ-failure and death. Given that currently the treatment of this condition is rare and release of effective vaccine might be months away, here, we review the plants and their pharmacologically active-compounds as potential phytopharmaceuticals for the virus induced inflammatory response. Experimental validation of the effectiveness of these natural compounds to prevent or reduce the cytokine storm might be beneficial as an adjunct treatment of SARS-CoV-2.

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Effect of piperlongumine during exposure to cigarette smoke reduces inflammation and lung injury

Cited by 14 publications

References 46 publications

COVID-19, cytokines, inflammation, and spices: How are they related?

COVID-19, cytokines, inflammation, and spices: How are they related?

Annexin A1 Mimetic Peptide and Piperlongumine: Anti-Inflammatory Profiles in Endotoxin-Induced Uveitis

Phytotherapy for treatment of cytokine storm in COVID19

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Effect of piperlongumine during exposure to cigarette smoke reduces inflammation and lung injury

Cited by 14 publications

References 46 publications

COVID-19, cytokines, inflammation, and spices: How are they related?

COVID-19, cytokines, inflammation, and spices: How are they related?

Annexin A1 Mimetic Peptide and Piperlongumine: Anti-Inflammatory Profiles in Endotoxin-Induced Uveitis

Phytotherapy for treatment of cytokine storm in COVID­19

Contact Info

Product

Resources

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Phytotherapy for treatment of cytokine storm in COVID19