Effect of pilocarpine on behavior of mucus glycoproteins of canine tracheal secretory cells.

The Role of Vagal Reflex in Mechanism of Secretagogic Action of Bromhexine

“…This may be supported by the finding that the histochemical changes were not influenced by cholinergic blockade. The degrees of histological and histochemical changes observed in this in vivo study using [10][11][12][13][14][15][16][17][18][19][20] mg/kg of bromhexine roughly resembled those observed in the in vitro study using 10-6-10-5 M/l of bromhexine.…”

“…It was found that the secretagogic action of bromhexine results from a selective promotion of the secretory activity of submucosal glands in the lamina propria mucosae of the respiratory tract and that the mucolytic action of the agent results from a dissolution of acid glycoprotein (AGP), a chief viscous factor (7,8), contained in mucus granules of both goblet cells in the epithelium and submucosal glandular cells (9-1 1 ). In a previous paper, we reported an in vitro result that the et al The analytical method for photomicrographs of submucosal glands in the tracheal tissues were described previously (9)(10)(11)(13)(14)(15)(16)(17)(18). In this study, the ratio of acinar inner diameter of submucosal gland to the tracheal wall thickness (AMR) was used to represent the histological parameters.…”

Mucoactive drugs for asthma and COPD: any place in therapy?

“…It is derived from the alkaloid vasicine (from Adhatoda vasica nees) and reduces the elasticity and viscosity of mini-pig tracheal mucus after oral dosing [181]. Bromhexine stimulates mucus secretion by canine tracheal submucosal glands, without affecting secretion from goblet cells [182]. In a multicentre placebo-controlled trial of 237 patients with COPD, oral bromhexine (30 mg b.i.d.)…”