Effect of phytosterols on reducing low-density lipoprotein cholesterol in dogs

Borin-Crivellenti, Sofia; Crivellenti, Leandro Zuccolotto; Oliveira, Frederico Rocha; Costa, Paula Barbosa; Alvarenga, Alef W.O.; Rezende, Luara Rodrigues; Gouvêa, Fernanda Nastri; Assef, Najla D.; Branco, Luana de Oliveira

doi:10.1016/j.domaniend.2021.106610

Cited by 5 publications

(2 citation statements)

References 22 publications

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“…Compared with omnivorous and herbivorous fish, carnivorous fish have a lower ability to make use of dietary carbohydrates. Excessive dietary carbohydrates generally cause persistent glycogen deposition (Wu et al, 2016;Lin et al, 2018;Ma et al, 2019), induce an immune response (Hu et al, 2017;Cheng et al, 2020;Borin-Crivellenti et al, 2021) and further impair the growth and health status of cultured carnivorous fish. Therefore, studies on how to alleviate hepatic glycogen deposition caused by high dietary carbohydrates, which may contribute to coping with the nutritional-technological conundrum in manufacturing aquafeeds of carnivorous fish, should receive much attention.…”

Section: Introductionmentioning

confidence: 99%

Phytosterol supplementation enhances the growth performance, feed utilization, antioxidant status and glucose metabolism of juvenile largemouth bass (Micropterus salmoides) fed a high-starch diet

Liang,

Huang,

Zhu

et al. 2024

Front. Mar. Sci.

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IntroductionPrevious studies found that phytosterols could influence growth performance, feed utilization and lipid metabolism as well as improve the antioxidant capacity of animals.MethodsTo investigate the effects of dietary phytosterol supplementation on juvenile largemouth bass (Micropterus salmoides) fed a high-starch diet, a 56- day feedingtrial was conducted with four dietary feeds for juvenile largemouth bass: extruded floating feed isonitrogenous and isoenergetic diets were formulated to contain 10% and 15% α-starch; on the basis of a 15% α-starch diet, two other diets were formulated with supplementation of 0.1% and 0.5% phytosterol, respectively. After the feeding trials, the survival rate, weight gain and specific growth rate, feed conversion ratio, intraperitoneal fat ratio, feed intake, protein efficiency ratio and activities of three digestive enzymes, as well as the concentrations of nine plasma biochemical indices, hepatic enzyme activities and glycogen contents, were measured and calculated, and the data were statistically analyzed.ResultsThe results of the present study showed that the survival rate, weight gain and specificgrowthrates were significantly greater in plants fed high-starch diets supplemented with phytosterols. As the supplemental phytosterol concentration increased, the feed conversion ratio and intraperitoneal fat ratio significantly decreased; the protease and lipase levels in the pyloric zone markedly increased; the plasma cholesterol, triglyceride, glucose, malondialdehyde, aspartate transaminase and alanin transaminase levels significantly decreased; the glucokinase and pyruvate kinase levelsmarkedly increased; and the hepatic glycogen content significantly decreased.DiscussionIn summary, dietary phytosterol supplementation promoted the growth performance, feed utilization and antioxidant status of juvenile largemouth bass fed a highstarch diet; enhanced glucose utilization and metabolism; and alleviated the negative stimulation of glycemia stress in M. salmoide fed a high-starch diet.

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Section: Introductionmentioning

confidence: 99%

Phytosterol supplementation enhances the growth performance, feed utilization, antioxidant status and glucose metabolism of juvenile largemouth bass (Micropterus salmoides) fed a high-starch diet

Liang,

Huang,

Zhu

et al. 2024

Front. Mar. Sci.

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“…Statin therapy is highly effective in reducing LDL-C up to 50% in hypercholesterolemic individuals . Along with medication, dietary phytosterols (PSs) have gained popularity as adjuvant therapy due to their well-established LDL-C-lowering properties. − PSs at a daily oral dose of 2 g can reduce serum LDL-C in the range of 8–14%. − PSs inhibit the intestinal absorption of cholesterol by competing with cholesterol for solubilization in bile salt micelles . Numerous clinical studies have demonstrated that the extent of LDL-C reduction by PSs is dependent on their formulation.…”

Section: Introductionmentioning

confidence: 99%

Liposomal Phytosterols as LDL-Cholesterol-Lowering Agents in Diet-Induced Hyperlipidemia

et al. 2023

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The high blood level of low-density lipoprotein cholesterol (LDL-C) is a primary risk factor for cardiovascular disease. Plant sterols, known as phytosterols (PSs), can reduce LDL-C in a range of 8–14%. The extent of LDL-C reduction depends on its formulation. Encapsulation into liposomes is one formulation strategy to enhance the efficiency of PSs. PSs (campesterol, stigmasterol, and β-sitosterol) have frequently been assessed alone or in combination for their LDL-C-lowering ability. However, one naturally abundant PS, brassicasterol, has not yet been tested for its efficacy. We have previously developed a novel liposomal formulation containing the PS mixture present naturally in canola that is composed of brassicasterol, campesterol, and β-sitosterol. In this work, the efficacy of our novel liposomal PS formulation that includes brassicasterol was assessed in a hamster model. Animals were divided into five groups: (i) liposomal PS in orange juice, (ii) liposomal PS in water, (iii) marketed PS in orange juice, (iv) control orange juice, and (v) control water. The animals were fed a high-fat, cholesterol-supplemented (0.5%) diet to induce hypercholesterolemia. The treatment was administered orally once daily for 4 weeks. Fasting blood samples were collected at baseline, week 2, and week 4. The extent of the reduction of total cholesterol, LDL-C, high-density lipoprotein cholesterol (HDL-C), and triglycerides was compared among the groups. Liposomal PSs in both orange juice and water significantly reduced LDL-C compared to their controls. Furthermore, the liposomal PS was as effective as a marketed PS-containing product in reducing LDL-C. Liposomal PSs in both orange juice and water showed similar efficacy in LDL-C reduction, highlighting that these vehicles/food matrices do not affect the efficacy of PSs. The liposomal formulation of a natural PS mixture extracted from canola oil, with brassicasterol as a major component, exhibited a significant LDL-C reduction in a hamster model.

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Integrated metabolomics and transcriptomics analyses reveal the key genes regulating differential metabolites of longissimus dorsi muscle in castrated South Sichuan black goats (Capra hircus)

Zhang

Xing

Wang

et al. 2023

Funct Integr Genomics

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Effect of phytosterols on reducing low-density lipoprotein cholesterol in dogs

Cited by 5 publications

References 22 publications

Phytosterol supplementation enhances the growth performance, feed utilization, antioxidant status and glucose metabolism of juvenile largemouth bass (Micropterus salmoides) fed a high-starch diet

Phytosterol supplementation enhances the growth performance, feed utilization, antioxidant status and glucose metabolism of juvenile largemouth bass (Micropterus salmoides) fed a high-starch diet

Liposomal Phytosterols as LDL-Cholesterol-Lowering Agents in Diet-Induced Hyperlipidemia

Integrated metabolomics and transcriptomics analyses reveal the key genes regulating differential metabolites of longissimus dorsi muscle in castrated South Sichuan black goats (Capra hircus)

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