Effect of physicochemical properties of adhesive on the release, skin permeation and adhesiveness of adhesive-type transdermal drug delivery systems (a-TDD) containing silicone-based pressure-sensitive adhesives

Adhesive properties: a critical issue in transdermal patch development

“…3.3 Silicon-based PSA Silicon-based PSAs are made up of a long chain polymer (polydimethyl siloxane) and a silicate resin [36]. The resin has a high glass transition, while the polymer has a notably low glass transition.…”

Manipulation of Corticosteroid Release from a Transiently Supersaturated Topical Metered Dose Aerosol Using A Residual Miscible Co-Solvent

“…The most common test performed to measure tackiness is the peel test, which assesses the force necessary to pry a film from another object, e.g. a tablet or a pressure sensitive adhesive (PSA) liner (36). The peel force is then extrapolated to the likelihood of the film staying affixed to the topical surface.…”

Predicting the Octanol Solubility of Organic Compounds

“…The reported octanol solubilities and melting points of 224 compounds were taken from the literature (see Table S1) 1,9,12–35. The molar volumes and solubility parameters were taken from literature36–50 or calculated using Fedors' group contribution method 51. For compounds with multiple octanol solubility or solubility parameter values, the values were averaged.…”