Effect of Physical Training on Exercise-Induced Inflammation and Performance in Mice

Barcellos, Luiz Alexandre Medrado de; Gonçalves, William; Oliveira, Marcos Paulo Esteves de; Guimarães, Juliana Bohnen; Queiroz-Júnior, Celso Martins; Resende, Carolina Braga de; Russo, Remo Castro; Coimbra, Cândido Celso; Silva, Albená Nunes; Teixeira, Mauro Martins; Rezende, Bárbara Antunes; Pinho, Vanessa

doi:10.3389/fcell.2021.625680

Cited by 16 publications

(14 citation statements)

References 38 publications

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“…In this context, clinical studies have shown that regular physical exercise in the form of high‐intensity interval training (HIIT) and continuous training (CT) can prevent pathological diseases, including pulmonary and cardiovascular diseases, diabetes mellitus, metabolic syndrome and cases associated with systemic inflammation (Amirazodi et al., 2022 ). Accordingly, exercise‐induced biochemical changes increase the amount of circulating inflammatory cells and cytokines to maintain physiological homeostasis (Barcellos et al., 2021 ), and antioxidant increases are associated with post‐exercise immune system changes (cell adhesion, lymphocyte proliferation and inflammation). Previous studies have supported that CT increases the efficiency of immune function, decreases serum levels of markers of inflammation, and also suppresses nuclear factor‐κB (NF‐κB) signalling and its proinflammatory targets interleukin (IL)‐6 and TNF‐α in rats (Liu & Chang, 2018 ; Petersen & Pedersen, 2005 ).…”

Section: Introductionmentioning

confidence: 99%

Comparison of preventive and therapeutic effects of continuous exercise on acute lung injury induced with methotrexate

Rajizadeh,

Hosseini,

Bahrami

et al. 2023

Experimental Physiology

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Methotrexate (Mtx) is used to treat various diseases, including cancer, arthritis and other rheumatic diseases. However, it induces oxidative stress and pulmonary inflammation by stimulating production of reactive oxygen species and cytokines. Considering the positive effects of physical activity, our goal was to investigate the preventive and therapeutic role of continuous training (CT) on Mtx‐induced lung injury in rats. The rats were divided into five groups of 14 animals: a control group (C); a continuous exercise training group (CT; healthy rats that experienced CT); an acute lung injury with Mtx group (ALI); a pretreatment group with CT (the rats experienced CT before ALI induction), and a post‐treatment group with CT (the rats experienced CT after ALI induction). One dose of 20 mg/kg Mtx intraperitoneal was administered in the Mtx and training groups. Forty‐eight hours after the last exercise session all rats were sacrificed. According to our results, the levels of tumour necrosis factor‐α (TNF‐α), malondialdehyde (MDA), myeloperoxidase (MPO), GATA binding protein 3 (GATA3) and caspase‐3 in the ALI group significantly increased compared to the control group, and the levels of superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC), interleukin‐10 (IL‐10), forkhead box protein 3 (FOXP3), and T‐bet decreased. In contrast, compared to the acute lung injury group, pretreatment and treatment with CT reduced TNF‐α, MDA, MPO, GATA3 and caspase‐3 and increased SOD, GPX, TAC, IL‐10, FOXP3 and T‐bet levels. The effects of CT pretreatment were more significant than the effects of CT post‐treatment. Continuous exercise training effectively reduced oxidative stress and inflammatory cytokines and ameliorated Mtx‐induced injury, and the effects of CT pretreatment were more significant than the effects of CT post‐treatment.New Findings What is the central question of this study? Considering the high prevalence of lung injury in society, does exercise as a non‐pharmacological intervention have ameliorating effects on lung injury? What is the main finding and its importance? Exercise can have healing effects on the lung after pulmonary injury through reducing inflammation, oxidative stress and apoptosis. Considering the lower side effects of exercise compared to drug treatments, the results of this study may be useful in the future.

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Section: Introductionmentioning

confidence: 99%

Comparison of preventive and therapeutic effects of continuous exercise on acute lung injury induced with methotrexate

Rajizadeh,

Hosseini,

Bahrami

et al. 2023

Experimental Physiology

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“…This suggests that the exacerbation of behavioral impairments induced by a combination of RS + ES is unlikely to be mediated through triggering these pro‐inflammatory biomarkers. Although an imbalance involving excessive exercise and inadequate recovery increases the production and release of pro‐inflammatory cytokines, initiating most of the signs and symptoms linked to performance decrement (da Rocha et al., 2019; de Barcellos et al., 2021), there is a paucity of studies evaluating its impact on maternal and neonatal inflammatory status and related neurobehavioral outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…In spite of this, prenatal zinc supplementation unexpectedly did not result in any improvement in behavioral and inflammatory consequences induced by the combination of RS and ES. As strenuous exercise alters blood immune and inflammatory profiles (Cerqueira et al., 2019; da Rocha et al., 2019; de Barcellos et al., 2021), it can increase the amount of circulating inflammatory cells and cytokines to maintain physiological homeostasis (Cerqueira et al., 2019; da Rocha et al., 2019; Ostrowski et al., 1999; Suzuki et al., 2002), which may mask or conceal the suppression effect of zinc on PS‐induced pro‐inflammatory responses.…”

Section: Discussionmentioning

confidence: 99%

The effects of forced exercise and zinc supplementation during pregnancy on prenatally stress‐induced behavioral and neurobiological consequences in adolescent female rat offspring

Sameei

Fatehfar

Abdollahzadeh

et al. 2023

Developmental Psychobiology

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Prenatal manipulations can lead to neurobehavioral changes in the offspring. In this study, individual and combined effects of forced exercise and zinc supplementation during pregnancy on prenatally restraint stress (PRS)‐induced behavioral impairments, neuro‐inflammatory responses, and oxidative stress have been investigated in adolescent female rat offspring. Pregnant rats were divided into five groups: control; restraint stress (RS); RS + exercise stress (RS + ES), RS + zinc supplementation (RS + Zn); and RS + ES + Zn. All the pregnant rats (except control) were exposed to RS from gestational days 15 to 19. Pregnant rats in ES groups were subjected to forced treadmill exercise (30 min/daily), and in Zn groups to zinc sulfate (30 mg/kg/orally), throughout the pregnancy. At postnatal days 25–27, anxiety‐like and stress‐coping behaviors were recorded, and the gene expressions of interleukin‐1β (IL‐1β) and tumor necrosis factor‐α (TNF‐α) and the concentration of total antioxidant capacity were measured in the prefrontal cortex. PRS significantly enhanced anxiety, generated passive coping behaviors, increased IL‐1β and TNF‐α expression, and decreased the antioxidant capacity. ES potentiated while zinc reversed PRS‐induced behavioral impairments. Prenatal zinc also restored the anti‐inflammatory and antioxidant capacity but had no effect on additive responses imposed by the combination of RS and ES. Suppression of PRS‐induced behavioral and neurobiological impairments by zinc suggests the probable clinical importance of zinc on PRS‐induced changes on child temperament.

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“…In the study by Libardi et al, the final blood sample was collected seven days following the last exercise session, and in the study by Eaton et al the final blood samples were taken just three hours after exercise intervention (27,28). It has been revealed that acute exercise increases the release of inflammatory indices (29). In addition, the difference in participants and baseline values of the variables can also explain the discrepancy, so that in the research by Libardi et al, the participants were healthy individuals with normal baseline values of the inflammatory cytokines (27).…”

Section: Discussionmentioning

confidence: 99%

Effect of Endurance Training and High-Fat Diet on Serum Interleukin-6 and 17 Levels in Male Wistar Rats

Nayebpoor

Bashiri

Gholami

2022

Hormozgan medical journal

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Background: High-fat diet (HFD) can cause several health problems and chronic inflammation. The aim of the study was to examine the effect of endurance training along with HFD on serum levels of interleukin-6 (IL-6) and IL-17 in male Wistar rats. Methods: In an experimental-controlled study, 36 male Wistar rats were randomly assigned to four groups of HFD, training (T), HFD + training (HFDT), and control (C). Exercise training consisted of 40 minutes of running on treadmill at the maximum speed of 55%-65%, five sessions per week for four weeks. Forty-eight hours following the last intervention, serum IL-6 and IL-17 levels were measured. Data analysis was conducted by one-way analysis of variance (ANOVA) and Tukey’s post hoc test at P<0.05. Results: The results showed that serum IL-6 and IL-17 levels significantly increased as a result of HFD (P=0.001). Endurance training decreased IL-6 and IL-17 levels and there was a significant difference between training and HFD groups (P=0.001). However, based on the difference between HFDT and control groups, the variables did not return to baseline values. Conclusion: According to the results, HFD induced inflammation in a short duration of four weeks manifested by elevated inflammatory indices. In contrast, endurance training ameliorated HFD-induced elevation of IL-6 and IL-17 and these levels did not return to baseline values.

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Effect of Physical Training on Exercise-Induced Inflammation and Performance in Mice

Cited by 16 publications

References 38 publications

Comparison of preventive and therapeutic effects of continuous exercise on acute lung injury induced with methotrexate

Comparison of preventive and therapeutic effects of continuous exercise on acute lung injury induced with methotrexate

The effects of forced exercise and zinc supplementation during pregnancy on prenatally stress‐induced behavioral and neurobiological consequences in adolescent female rat offspring

Effect of Endurance Training and High-Fat Diet on Serum Interleukin-6 and 17 Levels in Male Wistar Rats

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