Effect of Physical States of Binders on High-Shear Wet Granulation and Granule Properties: A Mechanistic Approach Toward Understanding High-Shear wet Granulation Process, Part 3: Effect of Binder Rheological Properties

The Effect of the Physical State of Binders on High-Shear Wet Granulation and Granule Properties: A Mechanistic Approach to Understand the High-Shear Wet Granulation Process. Part IV. The Impact of Rheological State and Tip-speeds

“…As mentioned by Mort, the rheological state of the binder is a critical factor affecting the granulation. The rheological properties of all four binders, after being exposed to 96% RH for 4 weeks, are listed in Table . As seen from Table , PVP K17 and PVP K29/32 exhibit viscous solution behavior after exposure, although the solution of PVP K29/32 is a little more viscous than that of PVP K17.…”

“…As shown in our previous studies, for a wet granulation process with a binder added in dry, the physical state change of a binder from a glassy state to a rubbery/solution state is the main factor influencing granule growth and the final granule properties . After transition, as indicated in the Part 3, the rheological properties such as viscosity of the binder in granulation, which depends on both binder molecular weight and water content, strongly impact the flow behavior of the binder during mixing . Consequently, the flow behavior of the binder in the granulation or coverage should influence the kinetics of the granule formation as well as the final granule properties .…”

“…The procedure for the preparation of dry blends used for this study is the same as that used for previous studies . The detailed description was described in a previous publication (Part 3 of this series) …”

“…6,7 After transition, as indicated in the Part 3, the rheological properties such as viscosity of the binder in granulation, which depends on both binder molecular weight and water content, strongly impact the flow behavior of the binder during mixing. 8 Consequently, the flow behavior of the binder in the granulation or coverage should influence the kinetics of the granule formation as well as the final granule properties. 9 In this study, three representative impeller tip speeds were selected, and the speed effect on granule growth at specific rheological states was examined.…”

Pharmaceutical properties of a low-substituted hydroxypropyl cellulose (L-HPC) hydrogel as a novel external dressing

“…The average substitution ratio of the hydroxypropyl group in typical HPC is 2.0-4.5 per glucose unit. The viscous properties of HPC in aqueous solution have been employed as a viscosity agent (thickener) for emulsions and as a binder in solid pharmaceutics (Li et al, 2012). In contrast, the lower substituted HPC, in which the substitution ratio is 0.1-0.5, is water-insoluble and is called low-substituted hydroxypropyl cellulose (L-HPC, Fig.…”