Effect of Physical State on Pain Mediated Through Emotional Health in Rheumatoid Arthritis

Nakagami, Yukako; Sugihara, Genichi; Takei, Nori; Fujii, Tomoyuki; Hashimoto, Motomu; Murakami, Kosaku; Furu, Moritoshi; Ito, Hiromu; Uda, Miyabi; Torii, Mie; Nin, Kazuko; Murai, Toshiya; Mimori, Tsuneyo

doi:10.1002/acr.23779

Cited by 16 publications

(9 citation statements)

References 36 publications

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“…Indeed, some genetic epidemiological studies have shown significant associations between the severity of depression and polymorphisms in inflammatory cytokine genes encoding IL-1β, IL-6, TNF and CRP [ 47 , 48 ]. Psychological stress, in turn, is thought to promote the inflammatory response via several immunomodulatory pathways [ 12 , 49 , 50 ], and can also exacerbate clinical symptoms and impair medical adherence, treatment response, and physical activity [ 8 , 9 , 51 ]. In addition, a large-scale cohort study has shown that exposure to a stress-related disorder is a risk factor for subsequent autoimmune disease [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Influence of dietary habits on depression among patients with rheumatoid arthritis: A cross-sectional study using KURAMA cohort database

et al. 2021

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Objective Although mental disorder is one of the most common comorbidities of rheumatoid arthritis (RA) and is known as a critical influence on RA remission rates, there is little knowledge regarding a possible therapeutic strategy for depression or anxiety in a RA population. Most recently, clinical evidence of dietary improvement for depression has emerged in a general population, but the relationship between dietary habits and mental disorder has not been investigated in RA. The purpose of this study is to elucidate clinical associations between mental disorder (depression/anxiety), dietary habits and disease activity/physical function in patients with RA. Methods A cross-sectional study was performed with 267 female outpatients from the KURAMA database. Using the Hospital Anxiety and Depression Scale (HADS), we classified the participants into three groups by depression state, and their characteristics were compared. Using the 20-items on the self-reported food frequency questionnaire, we investigated the relationship between dietary habits and depression or anxiety, adopting a trend test and a multivariate standardized linear regression analysis for the HADS score of depression or that of anxiety as a dependent variable. Results According to the classified stage of depression, current disease activity (DAS28-CRP: 28-Joint RA Disease Activity Score-C-reactive protein) and the health assessment questionnaire disability Index (HAQ-DI) were significantly increased. Trend analyses revealed that the depression score was inversely associated with the consumption of three food (fish, vegetables and fruit) out of twenty as was the anxiety score with only fish intake. Furthermore, multiple linear regression analysis revealed that the depression score was negatively associated with frequent fish intake (≥ 3 times per week) (Estimate -0.53, p = 0.033), HAQ-DI score within normal range (Estimate -0.88, p ≤ 0.001) and MTX use (Estimate -0.60, p ≤ 0.023). For the anxiety score, multivariate analysis showed similar but not significant associations with variables except for HAQ-DI score. Conclusions In a RA population, both depression and anxiety had a significant and negative association with HAQ-DI score, and depression rather than anxiety had negative association with frequent fish intake. Modification of dietary habits such as increased fish consumption may have a beneficial effect on the depression state in RA patients.

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Section: Discussionmentioning

confidence: 99%

Influence of dietary habits on depression among patients with rheumatoid arthritis: A cross-sectional study using KURAMA cohort database

et al. 2021

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“…Indeed, some genetic epidemiological studies have shown signi cant associations between the severity of depression and polymorphisms in in ammatory cytokine genes encoding IL-1β, IL-6, TNF and CRP [38,39]. Psychological stress, in turn, is thought to promote the in ammatory response via several immunomodulatory pathways [10,40,41], and can also exacerbate clinical symptoms and impair medical adherence, treatment response, and physical activity [7,8,42]. In addition, a large-scale cohort study has shown that exposure to a stress-related disorder is a risk factor for subsequent autoimmune disease [43].…”

Section: Discussionmentioning

confidence: 99%

Influence of Dietary Habits on Depression Among Patients With Rheumatoid Arthritis: A Cross-Sectional Study Using KURAMA Cohort Database

Minamino

Katsushima

Hashimoto

et al. 2021

Preprint

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BackgroundAlthough depression is one of the most common comorbidities of rheumatoid arthritis (RA) and is known as a critical influence on RA remission rates, there is little knowledge regarding a possible therapeutic strategy for depression in a RA population. Most recently, clinical evidence of dietary improvement for depression has emerged in a general population, but the relationship between dietary habits and depression has not been investigated in RA. The purpose of this study is to elucidate clinical associations between depression, dietary habits and disease activity/physical function in patients with RA.MethodsA cross-sectional study was performed with 267 female outpatients from the KURAMA database. Using the Hospital Anxiety and Depression Scale (HADS), we classified the participants into three groups by depression state, and their characteristics were compared. Using the 20-items on the self-reported food frequency questionnaire, we investigated the relationship between dietary habits and depression or anxiety, adopting a trend test and a multivariate standardized linear regression analysis for the HADS score as a dependent variable.ResultsClassification of the depressive state revealed that current disease activity and physical dysfunction (28-Joint RA Disease Activity Score-C-reactive protein (DAS28-CRP) as well as the health assessment questionnaire disability Index (HAQ)) were significantly increased according to the stage of depression. Trend analysis identified three of 20 foods, i.e., fish, vegetables and fruit, the consumption of which was inversely associated with the depression score. Furthermore, multiple linear regression analysis revealed that the depression score was negatively associated with frequent fish intake (> 3 times per week) (Estimate -0.53, p = 0.033) as well as remission of HAQ (Estimate -0.88, p ≤ 0.001). For the anxiety score, none of the dietary habits showed any correlation in the multiple regression analysis.ConclusionDepression state assessed by HADS score was significantly and independently associated with both fish intake frequency and remission of physical dysfunction in an RA population. Modification of dietary habits, such as that by increased fish consumption, may have a beneficial effect on the depression state in RA patients.

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“…Physical state changes (e.g., age, health status, etc.) could also worsen the perception of pain [14].…”

Section: Mechanism Of Painmentioning

confidence: 99%

Pain and Stress Detection Using Wearable Sensors and Devices—A Review

Chen

Abbod

Shieh

2021

Sensors

111

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Pain is a subjective feeling; it is a sensation that every human being must have experienced all their life. Yet, its mechanism and the way to immune to it is still a question to be answered. This review presents the mechanism and correlation of pain and stress, their assessment and detection approach with medical devices and wearable sensors. Various physiological signals (i.e., heart activity, brain activity, muscle activity, electrodermal activity, respiratory, blood volume pulse, skin temperature) and behavioral signals are organized for wearables sensors detection. By reviewing the wearable sensors used in the healthcare domain, we hope to find a way for wearable healthcare-monitoring system to be applied on pain and stress detection. Since pain leads to multiple consequences or symptoms such as muscle tension and depression that are stress related, there is a chance to find a new approach for chronic pain detection using daily life sensors or devices. Then by integrating modern computing techniques, there is a chance to handle pain and stress management issue.

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Effect of Physical State on Pain Mediated Through Emotional Health in Rheumatoid Arthritis

Cited by 16 publications

References 36 publications

Influence of dietary habits on depression among patients with rheumatoid arthritis: A cross-sectional study using KURAMA cohort database

Influence of dietary habits on depression among patients with rheumatoid arthritis: A cross-sectional study using KURAMA cohort database

Influence of Dietary Habits on Depression Among Patients With Rheumatoid Arthritis: A Cross-Sectional Study Using KURAMA Cohort Database

Pain and Stress Detection Using Wearable Sensors and Devices—A Review

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Effect of Physical State on Pain Mediated Through Emotional Health in Rheumatoid Arthritis

Cited by 16 publications

References 36 publications

Influence of dietary habits on depression among patients with rheumatoid arthritis: A cross-sectional study using KURAMA cohort database

Influence of dietary habits on depression among patients with rheumatoid arthritis: A cross-sectional study using KURAMA cohort database

Influence of Dietary Habits on Depression Among Patients With Rheumatoid Arthritis: A Cross-Sectional Study Using KURAMA&nbsp;Cohort Database

Pain and Stress Detection Using Wearable Sensors and Devices—A Review

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Influence of Dietary Habits on Depression Among Patients With Rheumatoid Arthritis: A Cross-Sectional Study Using KURAMA Cohort Database