Effect of physical exercise on adoptive experimental auto-immune encephalomyelitis in rats

Abstract

The aim of the study was to determine whether different programmes of exercise influence adoptive monophasic experimental auto-immune encephalomyelitis (adoptive EAE), a paralytic disease mediated by T-cells. Adoptive EAE was induced by the transfer of activated encephalitogenic T-lymphocytes into syngeneic recipients (Lewis rats, n = 85) and its development was followed by two independent observers. The results showed that 2 days of severe exercise (250 and 300 min) performed after the adoptive transfer of EAE slightly delayed the onset of the disease (P <0.008) and the day of its maximal severity (P <0.016) without affecting the overall severity of the disease. When this programme of exercise was performed before the cell transfer, it had no effect (P > 0.05). Two more moderate exercise programmes (5 x 120 min of running at constant speed or 5 x 60 min of running at variable speed, 5 consecutive days) performed between the adoptive transfer and the onset of the disease did not modify the development of the clinical signs of adoptive EAE (P >0.05). These results showed that severe exercise slightly influenced the effector phase of monophasic EAE and confirmed that physical exercise performed before the onset of experimental auto-immune diseases did not exacerbate the clinical signs.

Impact of aerobic training on immune-endocrine parameters, neurotrophic factors, quality of life and coordinative function in multiple sclerosis

“…Studies in experimental autoimmune encephalomyelitis (EAE), an animal model of MS, have shown that exercise during the induction phase of the disease does not aggravate the course of disease [10]. None of the clinical MS studies mentioned above reported enhancement of the inflammatory activity or exercise-induced exacerbations (for review, see Ref.…”

Effects of Exercise Intensity in Experimental Autoimmune Encephalomyelitis

“…Other authors also reported delayed onset of clinical EAE signs following voluntary wheel running in chronic EAE mice [5] and treadmill running in rats [3,4]. It is difficult to compare different studies due to application of different exercise intensities (lower versus higher intensities) or due to the use of voluntary exercise versus quantified training load and intensity.…”

“…So far, research investigating the impact of EAE and/or physical exercise during EAE on muscle contractile properties and EAE progression is scarce, conflicting but also promising [2][3][4][5]. De Haan and co-workers explored the impact of EAE on muscle contractile properties.…”

MS, exercise, and the potential for older adults

“…While there is no cure for MS, exercise appears to be beneficial at multiple levels, and it may have an important role to play in delaying negative symptoms of the disease. For example, animal research has suggested that exercise might provide an antiinflammatory effect, potentially slowing the disease process [21]. Extending this research to human participants is an important next step in MS research.…”