Effect of physical activity on risk of Alzheimer's disease: A systematic review and meta-analysis of twenty-nine prospective cohort studies

Zhang, Xiaoqian; Li, Qu; Cong, Wenqiang; Mu, Siyu; Zhan, Rui; Zhong, Shanshan; Zhao, Mei; Zhao, Chuansheng; Kang, Kexin; Zhou, Zhike

doi:10.1016/j.arr.2023.102127

Cited by 6 publications

(5 citation statements)

References 59 publications

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“…These findings were largely robust across multiple sensitivity analyses. This is consistent with prior research documenting an association between higher PA and better cognitive performance [35] and lower risk of dementia [1][2][3], as well as research reporting that individuals living with MCI/dementia exhibit differences in objectively measured PA patterns [36]. Potential mechanisms explaining these associations include higher PA leading to increased brain neurotrophic factors [35,37] and cerebral blood flow [35,37] or decreased inflammation [35], stress overactivity [35], and cardiovascular risk factors [2,38].…”

Section: Discussionsupporting

confidence: 87%

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Associations of Physical Activity and Heart Rate Variability from a Two-Week ECG Monitor with Cognitive Function and Dementia: The ARIC Neurocognitive Study

Marino,

Wu,

Etzkorn

et al. 2024

Sensors

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Low physical activity (PA) measured by accelerometers and low heart rate variability (HRV) measured from short-term ECG recordings are associated with worse cognitive function. Wearable long-term ECG monitors are now widely used, and some devices also include an accelerometer. The objective of this study was to evaluate whether PA or HRV measured from long-term ECG monitors was associated with cognitive function among older adults. A total of 1590 ARIC participants had free-living PA and HRV measured over 14 days using the Zio® XT Patch [aged 72–94 years, 58% female, 32% Black]. Cognitive function was measured by cognitive factor scores and adjudicated dementia or mild cognitive impairment (MCI) status. Adjusted linear or multinomial regression models examined whether higher PA or higher HRV was cross-sectionally associated with higher factor scores or lower odds of MCI/dementia. Each 1-unit increase in the total amount of PA was associated with higher global cognition (β = 0.30, 95% CI: 0.16–0.44) and executive function scores (β = 0.38, 95% CI: 0.22–0.53) and lower odds of MCI (OR = 0.38, 95% CI: 0.22–0.67) or dementia (OR = 0.25, 95% CI: 0.08–0.74). HRV (i.e., SDNN and rMSSD) was not associated with cognitive function. More research is needed to define the role of wearable ECG monitors as a tool for digital phenotyping of dementia.

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Section: Discussionsupporting

confidence: 87%

“…Physical activity (PA) is a known modifiable risk factor for cognitive impairment and dementia [1][2][3]. There is a growing interest in objectively measuring PA using accelerometers.…”

Section: Introductionmentioning

confidence: 99%

Associations of Physical Activity and Heart Rate Variability from a Two-Week ECG Monitor with Cognitive Function and Dementia: The ARIC Neurocognitive Study

Marino,

Wu,

Etzkorn

et al. 2024

Sensors

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“…Hence, there is also a necessity for subsequent meta-analyses in this area to realize the popularized 2nd-level efficacy analysis. Third, recently, a great number of meta-analyses have also revealed that aerobic exercise such as physical activity and exercise interventions could significantly improve cognitive performance and reduce the incidence of AD ( Groot et al, 2016 ; Zhou, 2018 ; López-Ortiz et al, 2021 ; Zhang et al, 2023 ). Therefore, it will be a novel direction to compare the differences between hyperbaric oxygen intervention and aerobic exercise in future research.…”

Section: Discussionmentioning

confidence: 99%

Clinical evidence of hyperbaric oxygen therapy for Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials

Lin,

Zhao,

Lin

et al. 2024

Front. Aging Neurosci.

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ObjectiveTo evaluate the potential benefits of hyperbaric oxygen intervention on people with Alzheimer’s disease (AD) based on the existing randomized controlled trials (RCTs).MethodsA systematic search was conducted in nine databases until November 17, 2023, for RCTs assessing the effect of hyperbaric oxygen intervention for AD. The primary outcomes included Mini-Mental State Examination (MMSE), Alzheimer’s Disease Assessment Scale-Cognitive (ADAS-Cog), activities of daily living (ADL), and adverse events. All results were shown in forest plots, and sensitivity analysis was adopted to further verify the robustness of the pooled results.ResultsA total of 11 RCTs recruiting 847 participants were included in this meta-analysis. Based on the pooled evidence, hyperbaric oxygen could remarkably ameliorate MMSE [MD = 3.08, 95%CI (2.56, 3.61), p < 0.00001], ADAS-Cog [MD = −4.53, 95%CI (−5.05, −4.00), p < 0.00001], ADL [MD = 10.12, 95%CI (4.46, 15.79), p = 0.0005], MDA levels [SMD = −2.83, 95%CI (−5.27, −0.38), p = 0.02], SOD levels [SMD = 2.12, 95%CI (1.10, 3.15), p < 0.0001], IL-1-β levels [SMD = −1.00, 95%CI (−1.48, −0.53), p < 0.0001], and TGF-β1 levels [MD = 4.87, 95%CI (3.98, 5.76), p < 0.00001] without adverse events [OR = 1.17, 95%CI (0.68, 2.03), p = 0.58] for people with AD. The pooled results were robust after checking by sensitivity analysis.ConclusionThese evidences suggest that hyperbaric oxygen is an effective and safe intervention for the treatment of AD. Further studies with more rigorous design will help to fully evaluate the clinical value of hyperbaric oxygen on cognition function in people with AD.Systematic review registrationhttps://www.crd.york.ac.uk, identifier CRD42023483726.

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“…Neurodegenerative diseases predominantly manifest as sporadic conditions, with fewer instances of hereditary transmission, affecting the central nervous system and resulting in the gradual and progressive deterioration of specific neuronal populations and their interconnections [1]. Given the ongoing aging trend and the extension of our life expectancy, the incidence of dementia is anticipated to rise significantly in the coming years [2,3].…”

Section: Introductionmentioning

confidence: 99%

The Role of Oxygen Homeostasis and the HIF-1 Factor in the Development of Neurodegeneration

Mitroshina,

Vedunova

2024

IJMS

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Understanding the molecular underpinnings of neurodegeneration processes is a pressing challenge for medicine and neurobiology. Alzheimer’s disease (AD) and Parkinson’s disease (PD) represent the most prevalent forms of neurodegeneration. To date, a substantial body of experimental evidence has strongly implicated hypoxia in the pathogenesis of numerous neurological disorders, including AD, PD, and other age-related neurodegenerative conditions. Hypoxia-inducible factor (HIF) is a transcription factor that triggers a cell survival program in conditions of oxygen deprivation. The involvement of HIF-1α in neurodegenerative processes presents a complex and sometimes contradictory picture. This review aims to elucidate the current understanding of the interplay between hypoxia and the development of AD and PD, assess the involvement of HIF-1 in their pathogenesis, and summarize promising therapeutic approaches centered on modulating the activity of the HIF-1 complex.

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Effect of physical activity on risk of Alzheimer's disease: A systematic review and meta-analysis of twenty-nine prospective cohort studies

Cited by 6 publications

References 59 publications

Associations of Physical Activity and Heart Rate Variability from a Two-Week ECG Monitor with Cognitive Function and Dementia: The ARIC Neurocognitive Study

Associations of Physical Activity and Heart Rate Variability from a Two-Week ECG Monitor with Cognitive Function and Dementia: The ARIC Neurocognitive Study

Clinical evidence of hyperbaric oxygen therapy for Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials

The Role of Oxygen Homeostasis and the HIF-1 Factor in the Development of Neurodegeneration

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