Effect of physical activity and BMI SDS on bone metabolism in children and adolescents

Pimentel, Duarte Vaz; Suttkus, Anne; Vogel, Mandy; Lacher, Martin; Jurkutat, Anne; Poulain, Tanja; Ceglarek, Uta; Kratzsch, Jürgen; Kieß, Wieland; Körner, Antje; Mayer, Steffi

doi:10.1016/j.bone.2021.116131

Cited by 8 publications

(8 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previously, Mayer et al. studied 397 German children with a wide range of BMI (217 subjects without obesity, 180 subjects with obesity) and reported significantly higher bone formation as well as resorption markers in boys than in girls ( 34 ). In our present study, higher levels of serum BTMs in boys were observed both in the control and overweight/obese groups.…”

Section: Discussionmentioning

confidence: 99%

“…In our present study, higher levels of serum BTMs in boys were observed both in the control and overweight/obese groups. The higher serum BTMs in boys may be attributed to physical factors (higher physical activity and muscle strength in boys) and biological factors (gender hormones) ( 34 ). As a result of testosterone acting on periosteal apposition, boys have a greater width and size of bones than girls of the same age ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of BMI, Age, Gender, and Pubertal Stage on Bone Turnover Markers in Chinese Children and Adolescents

et al. 2022

View full text Add to dashboard Cite

ObjectivesTo ascertain the associations of serum bone turnover markers (BTMs) levels with body mass index (BMI) in Chinese children and adolescents, and whether the influence of BMI, age, pubertal stage on BTMs varied by gender.MethodsA total of 500 students (180 controls and 320 children and adolescents with overweight/obesity) aged 9–14 years were randomly selected from the Chinese National Survey on Students Constitution and Health Cohort. Serum levels of BTMs, including bone formation marker bone alkaline phosphatase (BAP), collagen type 1 C-terminal propeptide (CICP), and bone resorption markers C-terminal telopeptide of type-I collagen (CTX) were determined by commercial enzyme-linked immunosorbent assay kits. The associations among BMI, age, gender, pubertal stage, and BTMs were analyzed.ResultsSerum levels of CICP and CTX in overweight/obese children and adolescents were lower than those in controls (p<0.05). Moreover, after subgroup analysis stratified by gender, the decreased serum CICP and CTX levels in overweight/obese children and adolescents were observed only in boys (p<0.05). After adjustment of age and pubertal stage, there was a negative correlation between serum BAP and BMI in both boys and girls (p<0.05). However, the correlations between serum CICP, CTX levels, and BMI were significant in boys but not in girls. Serum BAP and CICP levels were independently correlated with BMI, age, gender, and pubertal stage, while CTX levels were independently correlated with BMI, age, and gender (p<0.05). BAP, CICP, and CTX levels showed a clear age, gender, and pubertal stage dependence with significantly higher values in boys (p<0.05).ConclusionsOur findings support the associations between serum BTMs levels and BMI in Chinese children and adolescents, and suggest age, gender, and pubertal stage differences in this relationship that warrant future studies.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Effect of BMI, Age, Gender, and Pubertal Stage on Bone Turnover Markers in Chinese Children and Adolescents

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Adolescents were asked about several physical activities, and a final score was estimated indicating their physical activity level. Physical activity is an important moderator linked to improvement of muscle mass and BMC in children and adolescents ( 43 ). For socioeconomic status, we used the School Vulnerability Index (SVI), which measures the vulnerability degree for pupils who attend public, subsidized, or private schools.…”

Section: Methodsmentioning

confidence: 99%

The inverse relationship between fatness and bone mineral content is mediated by the adolescent appendicular skeletal muscle mass index: The Cogni-Action Project

et al. 2022

View full text Add to dashboard Cite

BackgroundExcess adipose tissue negatively influences bone health during childhood, affecting future bone fragility diseases such as osteoporosis. However, little is known about how adolescent appendicular skeletal muscle mass index (ASMI) may mediate the relation between fatness and bone mineral content (BMC).MethodsThe sample comprised 1,296 adolescents (50% girls) aged 10–14. A principal component analysis was performed to obtain a factor made up of four fatness indicators (a) neck circumference, (b) kilograms of fat, (c) visceral fat area, and (d) waist-to-height ratio. BMC, kilograms of fat, visceral fat area, and appendicular skeletal muscle mass were obtained by a multi-frequency bioelectrical impedance analyzer. ASMI was calculated as the appendicular skeletal muscle mass divided by height squared (kg/m2). A mediation analysis was performed adjusting by age, sex, maturation, socioeconomic status, physical activity, and adolescents' body weight. We also explore differences by sex and nutritional status.ResultsThe fatness factor explained 71.5% of the proportion variance. Fatness was inversely associated with the ASMI and BMC, while the ASMI was positively related to BMC. Overall, the inverse relationship between fatness and BMC was partially mediated by the adolescents' ASMI (29.7%, indirect effect: B= −0.048, 95%CI −0.077 to −0.022), being higher in girls than in boys (32.9 vs. 29.2%). Besides, the mediation effect was higher in adolescents with normal body weight than with overweight-obese (37.6 vs 23.9%, respectively).ConclusionsThis finding highlighted the relevance of promoting healthy habits to reduce fatness and improve muscle mass in adolescents. Moreover, this highlights the central role of ASMI mediating the inverse association between fatness and BMC in female and male adolescents. Public health strategies should promote bone health in childhood, reducing the incidence of early osteopenia and osteoporosis.

show abstract

“…Obese children had significantly lower levels of calcium, phosphorus, ALP, 25(OH)D3, P1NP, and OC than healthy children of the same age, as well as lower mean height than normal children of the same age. 55 , 56 Obesity in children not only affects normal growth and development but also leads to metabolic diseases such as diabetes. A meta‐analysis confirmed that OC was reduced in almost all children with type 1 diabetes, and OC was negatively correlated with glycosylated hemoglobin.…”

Section: Application Of Btmsmentioning

confidence: 99%

“…Although studies have shown that the incidence of osteoporosis and fracture risk is significantly higher in children with obesity compared with healthy children, it is worth noting that DXA found no differences in osteoporosis between the two, 54 implying that monitoring bone metabolic status is critical for the bone health of children with obesity. Obese children had significantly lower levels of calcium, phosphorus, ALP, 25(OH)D3, P1NP, and OC than healthy children of the same age, as well as lower mean height than normal children of the same age 55,56 . Obesity in children not only affects normal growth and development but also leads to metabolic diseases such as diabetes.…”

Section: Application Of Btmsmentioning

confidence: 99%

Broad application prospects of bone turnover markers in pediatrics

Zhang

Huang

et al. 2022

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Background Bone turnover markers (BTMs) have been studied for application in clinical medicine. However, BTMs in children are challenging, and few studies explore these BTMs in children. The application of BTMs is complicated mainly due to pre‐analytical factors, variable reference intervals of age‐ and sex‐related BTMs for adolescents and children in different regions and laboratories. Therefore, laboratory testing of BTMs is critical for understanding pediatric bone development and metabolism, which provides additional information about bone development and diseases. Methods Literature search was conducted using the MeSH term “child” combined with the terms that bone turnover markers such as “osteocalcin,” “Procollagen type I N‐terminal propeptide,” “procollagen type I C‐terminal propeptide,” “osteocalcin,” “N‐terminal cross‐linked telopeptide,” and “C‐terminal cross‐linked telopeptide,” Several databases including Web of Science, Google Scholar, and PubMed were searched to obtain the relevant studies. Results BTMs represent the combined effects of skeletal development, growth, and remodeling in children, which can be used in clinical pediatrics to assist in the diagnosis and prognosis of bone metabolic disorders. Conclusion BTMs are clearly helpful for diagnosis and monitoring of bone growth and development as well as bone metabolic disorders.

show abstract

Effect of physical activity and BMI SDS on bone metabolism in children and adolescents

Cited by 8 publications

References 45 publications

The Effect of BMI, Age, Gender, and Pubertal Stage on Bone Turnover Markers in Chinese Children and Adolescents

The Effect of BMI, Age, Gender, and Pubertal Stage on Bone Turnover Markers in Chinese Children and Adolescents

The inverse relationship between fatness and bone mineral content is mediated by the adolescent appendicular skeletal muscle mass index: The Cogni-Action Project

Broad application prospects of bone turnover markers in pediatrics

Contact Info

Product

Resources

About