Effect of Phyllanthus amarus on Some Reproductive Indices of Male Albino Rats

Abstract

Background: Medicinal plants have been a good source of drugs for humans, but chronic and prolong use of medicinal plants like Phyllanthus amarus for the treatment of malaria and other disorders are issues of concerns. This study evaluated the effect of Phyllanthus amarus on reproductive organs and sperm parameters in albino rats.
 Materials and Methods: Twenty-four healthy male albino rats of 12 weeks old were assigned into four groups with six rats in each group using a Completely Randomized Design (CRD). The experimental animals were orally treated with Phyllanthus amarus. Group A served as the control and was given only water and feed; Group B, C and D received 100 mg/kgBW, 200 mg/kgBW and 300 mg/kgBW of Phyllanthus amarus respectively. Data obtained were analyzed using analysis of variance (ANOVA). The treatments lasted for a period of 65 days after two weeks of acclimatization.
 Results: The results showed statistically significant (p<0.05) reduction in weight of testes and epididymes, sperm motility, sperm viability, sperm count and sperm head abnormalities in male rats treated with Phyllanthus amarus when compared to the control. The sperm pH was not significantly (p>0.05) affected by Phyllanthus amarus among the different treatment groups in the experimental animals.
 Conclusion: Findings from the present study indicate that Phyllanthus amarus possesses a dose-dependent anti-fertility activity in amale albino rats under a sub-chronic course of administration.

An evaluation of sodium fluoride toxicity and the ameliorative potential of extract of Phyllantus amarus on reproductive hormones and lipid profile of adult male albino rats

“…This result agrees with work of [18] who observed that the methanol extracts of Phyllanthus amarus (800 mg/kg) caused an insignificant change in the levels of Luteinizing (LH) and Follicle stimulating (FSH) hormone. [19] in the study of the effect of Phyllanthus amarus on some reproductive indices of male albino rats observed reduction in weight of testes and epididymes, sperm motility, sperm viability, sperm count and sperm head abnormalities in male rats treated with Phyllanthus amarus when compared to the control.…”

In-Vivo Immunomodulatory Activity of Ethanolic Extracts of Aerial Parts of Phyllanthus Amarus Plant in Cyclophosphamide Induced Mice

“…2 Phyllanthus amarus is a small erect herbal plant that grows upto 10-50 cm and it has small leaves, its stem have green capsules with flowers and very small fruits that burst open when dry. This plant is commonly called stonebreaker 3 .Phyllanthus amarus is used in traditional medicine for gastrointestinal, kidney, liver, menorrhagia and other conditions. 4 Indian traditional systems of medicine like Siddha and Ayurveda have suggested to increase the body's natural resistance to disease under the concept of 'Rasayana'.…”