Effect of phototherapy on blood endothelin and nitric oxide levels: clinical significance in preterm infants

Abstract

Under phototherapy, blood levels of ET and NO were significantly higher in preterm infants, especially in preterm infants of < or =32 weeks GA.

Long-term hazards of neonatal blue-light phototherapy

“…Phototherapy may significantly affect the haemodynamics of various organs, increase the cerebral and peripheral blood flow, enhance transepidermal water loss, decrease the cardiac output and the renal and mesenteric blood flows, and cause reopening of the ductus arteriosus in preterm infants by modifying the blood endothelin and nitric oxide levels. 57,60 NBLP can induce a higher frequency of sister chromatid exchanges in the peripheral lymphocytes of preterm icteric neonates, 61,62 and also lead to oxidative stress. 8 The antioxidant defence capacity of low-birthweight, immature infants is considerably lower than that of term neonates.…”

Evaluation of the effects of phototherapy on cochlear function in newborns

“…Endothelin and nitric oxide are powerful vasoactive agents. In a study of 64 newborns with hyperbilirubinemia, phototherapy increased blood levels of endothelin and nitric oxide [22]. Phototherapy might increase cerebral blood flow in infants; the risk of intracranial haemorrhage might also increase for the same reason in ventilated, premature infants [6].…”

The side effects of phototherapy for neonatal jaundice: what do we know? What should we do?

“…NNPT has been reported to alter heart function by increasing the heart rate and diminishing the variability of heart rate and cardiac output while affecting blood vessel function by diminishing the mean arterial blood pressure and increasing peripheral blood flow [14,58,98]. The alteration of cardiovascular function and the fluid homeostasis after NNPT treatment can affect the closure of PDA.…”

“…Bronze baby syndrome [33,95] Case report 4 [21,77] Case series 4 Asthma [9,10] Case-control study 3b Allergic rhinitis and conjunctivitis [40] Case-control study 3b Melanotic nevus and skin cancers [81] Case report 4 [20,29,31,63] Case-control study 3b [25] Cohort study 2b Patent ductus arteriosus [14,19,98] Before-after study 2c [15,58] Cohort study 2b [76] RCT 1b Retinopathy of prematurity [101] Case-control study 3b [37,52] Cohort study 2b [39] Cross-sectional study 4 for NNPT is to use it only when really needed, considering risks and benefits, and following the officially available guidelines. Current guidelines for NNPT issued by the American Academy of Pediatrics (AAP) are widely accepted in clinical practice.…”