Effect of photodynamic therapy by 810 and 940 nm diode laser on Herpes Simplex Virus 1: An in vitro study

Namvar, Mahsa Alavi; Vahedi, Mohammad; Abdolsamadi, Hamidreza; Mirzaei, Alireza; Mohammadi, Younes; Jalilian, Farid Azizi

doi:10.1016/j.pdpdt.2018.11.011

Cited by 39 publications

(28 citation statements)

References 31 publications

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“…Antimicrobial PhotoDynamic Therapy (aPDT) relies on the application of a photosensitizer able to absorb appropriate wavelengths in the visible light range and to react with oxygen molecules inside and around cells, resulting in the production of singlet oxygen or other cytotoxic reactive oxygen species (ROS), which lead to cell death, after inducing photodamage. aPDT can efficiently kill a wide range of bacteria (both antibiotic-susceptible and multi-resistant strains), viruses, fungal, and protozoan parasites (Smijs and Pavel, 2011;Thomas et al, 2015;Wang et al, 2017;Alves et al, 2018;Andrade et al, 2018;Namvar et al, 2019) without causing development of resistance (Al-Mutairi et al, 2018;Ma et al, 2018). This approach is particularly advantageous against bacteria naturally producing and accumulating endogenous photosensitizers such as porphyrins and flavins (Plavskii et al, 2018), physiologically involved in several essential biological functions (e.g., respiration, biological oxidation, photosynthesis, sulfate reduction, metabolism of fats, carbohydrates, and proteins) (Shu et al, 2013;García-Angulo, 2017;Sepúlveda Cisternas et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

The in vitro Photoinactivation of Helicobacter pylori by a Novel LED-Based Device

et al. 2020

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The rise of antibiotic resistance is the main cause for the failure of conventional antibiotic therapy of Helicobacter pylori infection, which is often associated with severe gastric diseases, including gastric cancer. In the last years, alternative non-pharmacological approaches have been considered in the treatment of H. pylori infection. Among these, antimicrobial PhotoDynamic Therapy (aPDT), a light-based treatment able to photoinactivate a wide range of bacteria, viruses, fungal and protozoan parasites, could represent a promising therapeutic strategy. In the case of H. pylori, aPDT can exploit photoactive endogenous porphyrins, such as protoporphyrin IX and coproporphyrin I and III, to induce photokilling, without any other exogenous photosensitizers. With the aim of developing an ingestible LED-based robotic pill for minimally invasive intragastric treatment of H. pylori infection, it is crucial to determine the best illumination parameters to activate the endogenous photosensitizers. In this study the photokilling effect on H. pylori has been evaluated by using a novel LED-based device, designed for testing the appropriate LEDs for the pill and suitable to perform in vitro irradiation experiments. Exposure to visible light induced bacterial photokilling most effectively at 405 nm and 460 nm. Sub-lethal light dose at 405 nm caused morphological changes on bacterial surface indicating the cell wall as one of the main targets of photodamage. For the first time endogenous photosensitizing molecules other than porphyrins, such as flavins, have been suggested to be involved in the 460 nm H. pylori photoinactivation.

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Section: Introductionmentioning

confidence: 99%

The in vitro Photoinactivation of Helicobacter pylori by a Novel LED-Based Device

et al. 2020

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“…Less frequently were the following PS naphthalene derivatives (Azidonaphthalene (AzNAP); 1,5-diazidonaphthalene (DAN); 1,5-Diiodonaphthalene (DINAP), 7.6% (n = 3/39) [ 37 ], oxazolidine (JL103, JL118, JL122), 7.6% (n = 3/39) [ 33 ] and to Amotosalen derivatives (Amotosalen-HCl and Amotosalen) 5% (n = 2/39) [ 52 , 53 ] respectively. The following PS were not grouped, and individually correspond to 2.6% (n = 1/39), such as 5-aminolevulinic acid (ALA) [ 36 ], Solid phase fullerene-based PS (SPFPS) [ 38 ], Ortoquin [ 32 ], Indocyanine green (ICG) [ 50 ], rhodanine derivative (LJ001) [ 33 ], Fotoditazine [ 60 ], Hypericin (Hy) [ 58 ], Diazidobiphenyl derivative (DABIPH) [ 37 ] and benzochlorine derivative (Zn-BC-AM) [ 43 ], Methylene blue (MB) [ 41 , 49 ] and curcumin (CUR) [ 51 , 57 ]. Highlight MB and CUR which were the most frequent PS in analyzed articles.…”

Section: Resultsmentioning

confidence: 99%

“… ZnPc-UCNs-PDT pointed the nanoparticles increased target specificity and it is promising to the treatment modality for localized viral infections. Lhotáková, Y., et al 2012 [ 50 ] Czech Republic Mouse polyomavirus (strain A2) Baculoviruses DNA (non-enveloped) DNA (enveloped) Swiss Albino mouse (3T6) fibroblasts Spodoptera frugiperda (Sf9) cells Tetraphenylporphyrin (TPP) 0, 0.001, 0.005 and 0.010% 30 minutes Xe lamp UV/VIS 400 nm - 300 W 10, 20 or 30 minutes - The TPP-PDT effect on mouse polyomavirus and baculovirus were performed with nanofibers materials containing TPP (polyurethane Tecophilic® and polycaprolactone (PCL)) and in water-soluble TPP (TPPS). For this, mouse polyomavirus at 1 × 10 5 and the recombinant baculovirus at 5 × 10 4 PFU were incubated on nanofibers textiles with TPP and TPPS in the dark, and irradiated.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of photodynamic therapy as an antiviral treatment: Potential guidance for dealing with SARS-CoV-2

Conrado

Sakita

Arita

et al. 2021

Photodiagnosis and Photodynamic Therapy

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Background SARS-CoV-2, which causes the coronavirus disease (COVID-19), presents high rates of morbidity and mortality and has affected thousands of people around the world. The search to eliminate SARS-CoV-2 is ongoing and urgent. This systematic review seeks to assess whether photodynamic therapy (PDT) could be effective in SARS-CoV-2 inactivation. Methods The focus question was: Can photodynamic therapy be used as potential guidance for dealing with SARS-CoV-2?”. A literature search, according to PRISMA statements, was conducted in the electronic databases PubMed, EMBASE, SCOPUS, Web of Science, LILACS, and Google Scholar. Studies published from January 2004 to June 2020 were analyzed. In vitro and in vivo studies were included that evaluated the effect of PDT mediated by several photosensitizers on RNA and DNA enveloped and non-enveloped viruses. Results From 27 selected manuscripts, 26 publications used in vitro studies, 24 were exclusively in vitro , and two had in vitro / in vivo parts. Only one analyzed publication was exclusively in vivo . Meta-analysis studies were unfeasible due to heterogeneity of the data. The risk of bias was analyzed in all studies. Conclusion The in vitro and in vivo studies selected in this systematic review indicated that PDT is capable of photoinactivating enveloped and non-enveloped DNA and RNA viruses, suggesting that PDT can potentially photoinactivate SARS-CoV-2.

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“…23 Moreover, the efficacy of ICG-mediated aPDT against different bacterial infections has been confirmed in several studies. [24][25][26][27] As commented by Namvar et al, 28 ICG with photothermal and photodynamic effects is a good candidate for virus inactivation by aPDT and has proved to be effective against herpes simplex virus. Geralde et al 29 evaluated the efficacy of aPDT with ICG (10 µmol/L) as a photosensitizer and extracorporeal illumination using an infrared light source with a 780 nm laser device for the treatment of pneumonia in an experimental mouse model.…”

Section: Discussionmentioning

confidence: 96%

Computational Biology Analysis of COVID-19 Receptor-Binding Domains: A Target Site for Indocyanine Green Through Antimicrobial Photodynamic Therapy

Pourhajibagher

Bahador

2020

J Lasers Med Sci

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Introduction: The receptor-binding domain (RBD) in SARS-CoV-2 binds strongly to angiotensinconverting enzyme 2 (ACE2) receptors and causes coronavirus disease 2019 (COVID-19). Antimicrobial photodynamic therapy (aPDT) is a well-established treatment option for the treatment of several viral infections. This in silico study was conducted to target the RBD of SARS-CoV-2 as a target site for aPDT. Methods: SARS-CoV-2-RBD was selected as a novel target for indocyanine green (ICG) as a photosensitizer during aPDT to exploit its molecular modeling, hierarchical nature of protein structure, and physico-chemical properties using several bioinformatic tools. The binding mode of the RBD to ICG was assessed via protein-ligand docking. Results: The results of a computational biology analysis revealed that SARS-CoV-2-RBD has 223 amino acids with a molecular weight of 25098.40 Da. RBD is most similar to 6W41 with an E-value of 4e-167, identity of 100%, and query cover of 100%. The aliphatic index of the RBD protein sequences was 71.61, suggesting that the protein is stable in a broad spectrum of temperatures. The predicted structure of RBD showed that it is a protein with a positive charge and a random coil structure (69.51%). Four ligands were modeled in this entry, including one N-acetyl-D-glucosamine (NAG), one glycerol (GOL), and two sulfate ions (SO 4), to which ICG desires to bind in the molecular docking analysis. Conclusion: Molecular modeling and simulation analysis showed that SARS-CoV-2-RBD could be a substrate for binding to ICG during aPDT to control the spread of COVID-19.

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Effect of photodynamic therapy by 810 and 940 nm diode laser on Herpes Simplex Virus 1: An in vitro study

Cited by 39 publications

References 31 publications

The in vitro Photoinactivation of Helicobacter pylori by a Novel LED-Based Device

The in vitro Photoinactivation of Helicobacter pylori by a Novel LED-Based Device

A systematic review of photodynamic therapy as an antiviral treatment: Potential guidance for dealing with SARS-CoV-2

Computational Biology Analysis of COVID-19 Receptor-Binding Domains: A Target Site for Indocyanine Green Through Antimicrobial Photodynamic Therapy

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