Effect of photobiomodulation therapy on reducing the chemo-induced oral mucositis severity and on salivary levels of CXCL8/interleukin 8, nitrite, and myeloperoxidase in patients undergoing hematopoietic stem cell transplantation: a randomized clinical trial

Salvador, D.; Soave, Danilo Figueiredo; Sacono, Nancy Tomoko; Castro, Eduardo Fernandes de; Silva, Geisa Badauy Lauria; Silva, Larissa Pereira e; Silva, Tarcı́lia Aparecida; Valadares, Marize Campos; Mendonça, Elismauro Francisco; Batista, Aline Carvalho

doi:10.1007/s10103-017-2263-1

Cited by 34 publications

(22 citation statements)

References 44 publications

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“…Similar to the studies with only adults, an increasing trend was observed in UWS TNF-a, however a decreasing trend was observed for UWS IL-1b several days after autologous and allogeneic HSCT [20]. Increasing trends were also observed for the cytokines IL-6, CXCL8/IL-8 and IL-10 the metalloproteinase MMP2/TIMP-2 and the growth factors FGF, EGF and VEGF levels in UWS several days after autologous and allogeneic HSCT [20,41]. Decreasing trends were observed for myeloperoxidase (MPO) and the matrix metalloproteinase MMP9/TIMP-2 [20,41].…”

Section: Saliva Compositionsupporting

confidence: 69%

“…Increasing trends were also observed for the cytokines IL-6, CXCL8/IL-8 and IL-10 the metalloproteinase MMP2/TIMP-2 and the growth factors FGF, EGF and VEGF levels in UWS several days after autologous and allogeneic HSCT [20,41]. Decreasing trends were observed for myeloperoxidase (MPO) and the matrix metalloproteinase MMP9/TIMP-2 [20,41]. In aGVHD patients (children 14 years of age and adults) similar trends for total protein (no change) and uric acid (decreasing trend) were observed compared to the studies including only adult HSCT recipients [17].…”

Section: Saliva Compositionmentioning

confidence: 99%

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Salivary Changes before and after Hematopoietic Stem Cell Transplantation: A Systematic Review

Leeuwen

Potting

Huysmans

et al. 2019

Biology of Blood and Marrow Transplantation

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A B S T R A C T Severe oral problems, including oral mucositis (OM) and xerostomia, often occur after conditioning therapy for hematopoietic stem cell transplantation (HSCT). Saliva plays a major role in protecting the oral mucosa and teeth. Alterations in salivary flow rate or salivary components resulting in decreased salivary defence mechanisms may affect oral/mucosal health and may influence the severity of OM. A systematic review was conducted to assess the current scientific knowledge on changes in salivary function and composition before and after HSCT. All English or Dutch articles examining salivary flow rate or salivary components before and after HSCT were included after title/abstract selection by 2 independent reviewers (weighted k = .91). After quality assessment and exclusion of all research groups with both children age <14 years and adults, 33 articles were included for data analysis. Overall, the salivary flow rate was decreased at several days and months after HSCT. Although several salivary components were studied, most components were examined in only 1 or 2 studies with different patient populations or at different time points after HSCT. At 7 days after HSCT, albumin and proinflammatory cytokines were increased, whereas secretory IgA and components of the salivary antioxidant system were decreased. Secretory IgA levels were still reduced at 1 month after HSCT but returned to pre-HSCT values at 6 months after HSCT. Lactoferrin, secretory leukocyte protease inhibitor, and b 2 -microglobulin levels were increased at 6 months after HSCT. Our findings show that changes in saliva reflect an inflammatory response occurring immediately after HSCT, followed by evidence of increased salivary antimicrobial defense mechanisms by 6 months after HSCT.

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Section: Saliva Compositionsupporting

confidence: 69%

Section: Saliva Compositionmentioning

confidence: 99%

Salivary Changes before and after Hematopoietic Stem Cell Transplantation: A Systematic Review

Leeuwen

Potting

Huysmans

et al. 2019

Biology of Blood and Marrow Transplantation

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“…It has been demonstrated by in vitro studies that phototherapy (PT) using laser light modulates cellular functions, such as cell migration and proliferation, even when these cells were exposed to inflammatory cytokines , indicating that this therapy may have biostimulatory effects from the activation of different cell pathways (MAPK/ERK) that induces cellular proliferation . A recent clinical trial also demonstrated the downregulation of several inflammatory mediators as CXCL8, IL‐8 and nitric oxide in saliva after PBM on patients scheduled for hematopoietic stem cell transplantation and planned treatment consisting of a high‐dose chemotherapy myeloablative conditioning regimen compared to control group .…”

Section: Introductionmentioning

confidence: 99%

Photobiomodulation in the Metabolism of Lipopolysaccharides‐exposed Epithelial Cells and Gingival Fibroblasts

Pansani

Basso

Soares

et al. 2018

Photochem & Photobiology

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This study assessed the effects of photobiomodulation (PBM) to cells previously exposed to lipopolysaccharides (LPS). Human gingival fibroblasts (HGF) and epithelial cells (HaCaT) were seeded in wells of 24-well plates containing complete culture medium (DMEM). After 24 h, the DMEM was replaced by serum-free DMEM, and cells were exposed to LPS of Escherichia coli (E. coli) (10 μg mL ) for 24, 48, and 72 h. The cells were subjected to specific parameters of phototherapy (PT) (LASERTable-InGaAsP-780 ± 3 nm, 25 mW, 3 J cm ). Cell proliferation (alamarBlue ), viability (Trypan Blue) and synthesis of CCL2 (ELISA) were evaluated. Data were statistically analyzed by the Kruskal-Wallis and Mann-Whitney test (α = 5%). Proliferation and viability of both cell lines decreased after LPS treatment at 48 and 72 h. Enhanced synthesis of CCL2 by gingival fibroblasts occurred at 24 h, while epithelial cells increased synthesis of this chemokine at 48 and 72 h. PBM enhanced cell proliferation and viability in a time-dependent manner for both cell lines exposed or not to LPS, while synthesis of CCL2 by cells exposed to PT decreased over time. PBM caused biomodulatory effects on gingival fibroblasts and epithelial cells previously treated with LPS. These effects may decrease tissue inflammatory response and accelerate wound healing of oral mucosal tissue.

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“…Among the most studied dental applications for PBM therapy, the strongest evidence currently supports its use in OM where it is already a part of adjunctive supportive care in oncotherapy (MASCC) (Lalla et al., ; Migliorati et al., ). OM is a common sequela of radiotherapy, chemotherapy (and their combinations) as well as with patients requiring hematopoietic stem cell transplants (Gupta, Dai, & Hamblin, ; Salvador et al., ). These treatments change the integrity of the mucous membrane, oral microbiota, and salivary composition and compromise the protection barriers of the oral cavity (Medeiros‐Filho, Maia Filho, & Ferreira, ; Scully, Epstein, & Sonis, ).…”

Section: Photobiomodulation Therapy In Oral Diseasesmentioning

confidence: 99%

Learning from clinical phenotypes: Low‐dose biophotonics therapies in oral diseases

et al. 2018

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This narrative review on the use of biophotonics therapies for management of oral diseases is written as a tribute to Prof. Crispian Scully. His seminal contributions to the field are highlighted by the detailed, comprehensive description of clinical presentations of oral diseases. This has enabled a more thorough, fundamental understanding of many of these pathologies by research from his group as well as inspired mechanistic investigations in many groups globally. In the same vein, a major emphasis of this narrative review is to focus on the evidence from human case reports rather than in vitro or in vivo animal studies that showcases the growing and broad impact of biophotonics therapies. The similarities and differences between two distinct forms of low-dose biophotonics treatments namely photodynamic therapy and photobiomodulation therapy are discussed. As evident in this review, a majority of these reports provide promising evidence for their clinical efficacy. However, a lack of adequate technical details, precise biological rationale, and limited outcome measures limits the current utility of these treatments. Future investigations should attempt to address these shortcomings and develop better designed, rigorous, controlled studies to fully harness the tremendous potential of low-dose biophotonics therapies.

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Effect of photobiomodulation therapy on reducing the chemo-induced oral mucositis severity and on salivary levels of CXCL8/interleukin 8, nitrite, and myeloperoxidase in patients undergoing hematopoietic stem cell transplantation: a randomized clinical trial

Cited by 34 publications

References 44 publications

Salivary Changes before and after Hematopoietic Stem Cell Transplantation: A Systematic Review

Salivary Changes before and after Hematopoietic Stem Cell Transplantation: A Systematic Review

Photobiomodulation in the Metabolism of Lipopolysaccharides‐exposed Epithelial Cells and Gingival Fibroblasts

Learning from clinical phenotypes: Low‐dose biophotonics therapies in oral diseases

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