“…These properties can control the activity of peptides. In particular, membrane charge and thickness have been shown to modulate the binding, aggregation, and activity of peptides ( 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ). Here, we seek to understand how these important aspects of lipid composition affect the macromolecular poration activity of the pHD peptides.…”