Effect of phosphate buffer on the micellisation process of Poloxamer 407: Microcalorimetry, acoustic spectroscopy and dynamic light scattering (DLS) studies

Perinelli, Diego Romano; Cespi, Marco; Pucciarelli, Stefania; Casettari, Luca; Palmieri, Gianni

doi:10.1016/j.colsurfa.2013.06.002

Cited by 27 publications

(16 citation statements)

References 38 publications

(55 reference statements)

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“…However, when compared to each other, the formulations P3.5, PFF3.5 and PFQ3.5 did not present hardness values that were statistically different (p > 0.05). Tests developed with poloxamer 407 demonstrate that the increase in the concentration of the polymer results in a higher micellar concentration, making the polymeric complex more resistant [ 50 , 51 ].…”

Section: Resultsmentioning

confidence: 99%

Photoprotection and skin irritation effect of hydrogels containing hydroalcoholic extract of red propolis: A natural pathway against skin cancer

Batista

Queiroz

Alves

et al. 2022

Heliyon

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The use of natural products in sunscreen formulations as a prophylactic measure against skin cancer is receiving special attention attributed to the photoprotective and antioxidant properties of their chemical components. In this work, we describe the development of topical hydrogel formulations containing hydroalcoholic extract of red propolis (HERP), and the evaluation of the dermal sensitizing effect of the developed products. Sunscreen formulations composed of HERP in different concentrations (1.5, 2.5 or 3.5% w/w) alone or in combination with a chemical (octyl methoxycinnamate) and/or physical (titanium dioxide) filters were developed using poloxamer 407 as gel basis. The preliminary and accelerated stability tests, texture analysis and spreadability tests were performed. All formulations revealed to be stable in preliminary stability assessment. The formulations containing HERP 1.5 and 2.5% alone or associated with the filters showed intense modifications during accelerated stability test, which were confirmed by rheological analyses. The incorporation of HERP and filters in the poloxamer hydrogel decreased the toughness of product (p < 0.05) and the formulation containing HERP alone presented the lowest adhesivity (p < 0.001). The incorporation of HERP in the hydrogel decreased the poloxamer transition temperature, showing different rheological behavior with the increase of HERP concentration. The developed formulations were stable, exhibited non-Newtonian and pseudoplastic behavior, showing in vivo skin compatibility and no skin irritancy.

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Section: Resultsmentioning

confidence: 99%

Photoprotection and skin irritation effect of hydrogels containing hydroalcoholic extract of red propolis: A natural pathway against skin cancer

Batista

Queiroz

Alves

et al. 2022

Heliyon

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“…[ 17 ] Poloxamer 407 contains ≈101 and 56 repeat units of PEO and PPO, respectively. [ 63 ] The solution and interfacial behavior of poloxamer 407 has been characterized using techniques including tensiometry, [ 64 ] dynamic light scattering (DLS), [ 65 ] cryogenic transition electron microscopy (cryo‐TEM), [ 66 ] and small angle neutron scattering (SANS). [ 67 ] Tensiometry reveals that poloxamer 407 exhibits a critical micelle concentration of 0.7% w/v at 15 °C, which is depressed to 0.005% w/v upon heating to 42 °C, indicating that an increase in temperature promotes the formation of micelles at lower concentrations (due to desolvation of the PPO core).…”

Section: Thermoreversible Gelatorsmentioning

confidence: 99%

Polymers Exhibiting Lower Critical Solution Temperatures as a Route to Thermoreversible Gelators for Healthcare

Cook

Haddow

Kirton

et al. 2020

Adv Funct Materials

133

113

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The ability to trigger changes to material properties with external stimuli, so‐called “smart” behavior, has enabled novel technologies for a wide range of healthcare applications. Response to small changes in temperature is particularly attractive, where material transformations may be triggered by contact with the human body. Thermoreversible gelators are materials where warming triggers reversible phase change from low viscosity polymer solution to a gel state. These systems can be generated by the exploitation of macromolecules with lower critical solution temperatures included in their architectures. The resultant materials are attractive for topical and mucosal drug delivery, as well as for injectables. In addition, the materials are attractive for tissue engineering and 3D printing. The fundamental science underpinning these systems is described, along with progress in each class of material and their applications. Significant opportunities exist in the fundamental understanding of how polymer chemistry and nanoscience describe the performance of these systems and guide the rational design of novel systems. Furthermore, barriers to translating technologies must be addressed, for example, rigorous toxicological evaluation is rarely conducted. As such, applications remain tied to narrow fields, and advancements will be made where the existing knowledge in these areas may be applied to novel problems of science.

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“…Specifically, this technique measures the variation of ultrasound parameters (sound speed and attenuation) when high-intensity ultrasound waves travel through the sample [ 8 ]. Being particularly sensitive to the structural changes in the material as a function of temperature and concentration, this technique has been successfully employed for the characterization of plenty of colloidal systems, investigated for their applications in pharmaceutical and biomedical fields [ 9 , 10 ]. Despite HR-US already being employed in some works for the characterization of the temperature-dependent behaviour (e.g., gel-to-sol transition) of liposomes composed of a single phospholipid [ 11 ] or a mixture of phospholipids and other components [ 12 , 13 ], a general overview of HR-US and liposomes characterization over temperature lacks in the literature.…”

Section: Introductionmentioning

confidence: 99%

High-Resolution Ultrasound Spectroscopy for the Determination of Phospholipid Transitions in Liposomal Dispersions

et al. 2022

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High-resolution ultrasound spectroscopy (HR-US) is a spectroscopic technique using ultrasound waves at high frequencies to investigate the structural properties of dispersed materials. This technique is able to monitor the variation of ultrasound parameters (sound speed and attenuation) due to the interaction of ultrasound waves with samples as a function of temperature and concentration. Despite being employed for the characterization of several colloidal systems, there is a lack in the literature regarding the comparison between the potential of HR-US for the determination of phospholipid thermal transitions and that of other common techniques both for loaded or unloaded liposomes. Thermal transitions of liposomes composed of pure phospholipids (dimyristoylphosphatidylcholine, DMPC; dipalmitoylphosphatidylcholine, DPPC and distearoylphosphatidylcholine, DSPC), cholesterol and their mixtures were investigated by HR-US in comparison to the most commonly employed microcalorimetry (mDSC) and dynamic light scattering (DLS). Moreover, tramadol hydrochloride, caffeine or miconazole nitrate as model drugs were loaded in DPPC liposomes to study the effect of their incorporation on thermal properties of a phospholipid bilayer. HR-US provided the determination of phospholipid sol-gel transition temperatures from both attenuation and sound speed that are comparable to those calculated by mDSC and DLS techniques for all analysed liposomal dispersions, both loaded and unloaded. Therefore, HR-US is proposed here as an alternative technique to determine the transition temperature of phospholipid membrane in liposomes.

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Effect of phosphate buffer on the micellisation process of Poloxamer 407: Microcalorimetry, acoustic spectroscopy and dynamic light scattering (DLS) studies

Cited by 27 publications

References 38 publications

Photoprotection and skin irritation effect of hydrogels containing hydroalcoholic extract of red propolis: A natural pathway against skin cancer

Photoprotection and skin irritation effect of hydrogels containing hydroalcoholic extract of red propolis: A natural pathway against skin cancer

Polymers Exhibiting Lower Critical Solution Temperatures as a Route to Thermoreversible Gelators for Healthcare

High-Resolution Ultrasound Spectroscopy for the Determination of Phospholipid Transitions in Liposomal Dispersions

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