Effect of phenylephrine on histamine-induced bronchoconstriction in dogs

Hirota, Kazuyoshi; Sato, Tetsumi; Hashimoto, Yuichi; Muraoka, Masahiro; Ishihara, Hironori; Matsuki, Akitomo

doi:10.1007/bf02480091

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…We have previously reported that divalent cations (Mg 2+ and Zn 2+ ) (12) and droperidol (27) produce bronchodilation and an increase in plasma catecholamines. In contrast, phenylephrine (28) and lidocaine (29) worsen histamine‐induced bronchoconstriction and result in a reduction of plasma catecholamines.…”

Section: Discussionmentioning

confidence: 99%

Spasmolytic effect of magnesium sulfate on serotonin‐induced pulmonary hypertension and bronchoconstriction in dogs

Yoshioka

Hirota

Sato

et al. 2001

Acta Anaesthesiol Scand

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Section: Discussionmentioning

confidence: 99%

Spasmolytic effect of magnesium sulfate on serotonin‐induced pulmonary hypertension and bronchoconstriction in dogs

Yoshioka

Hirota

Sato

et al. 2001

Acta Anaesthesiol Scand

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“…For another example, clinically relevant concentration of phenylephrine has been reported to exert no effects on airway smooth muscle tone [5]. However, we found that phenylephrine worsens histamine-induced bronchoconstriction [6]. As an increase in blood pressure by phenylephrine significantly reduces endogenous catecholamine release, which counteracts histamine-induced hypotension, a decrease in endogenous epinephrine release potentiates histamine-induced bronchoconstriction (Fig.…”

mentioning

confidence: 56%

Study on airway smooth muscle tone using fiberoptic bronchoscopy: basic research and clinical application

Hirota

2010

J Anesth

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“…28 Therefore, plasma catecholamines, especially epinephrine, may modulate airway smooth muscle tone. Indeed, we observed previously that histamine-induced bronchoconstriction was worsened by phenylephrine 16 and lidocaine, 17 with a reduction in plasma catecholamines, and reversed by droperidol 15 and divalent cations (Mg 2+ and Zn 2+ ) 18 with an increase in plasma catecholamines. Therefore, the decrease in plasma catecholamines may partially antagonize the relaxant effects of propofol.…”

Section: Discussionmentioning

confidence: 79%

Comparison of relaxant effects of propofol on methacholine-induced bronchoconstriction in dogs with and without vagotomy

Kabara

Hirota

Hashiba

et al. 2001

British Journal of Anaesthesia

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Propofol has been suggested to have in vivo airway relaxant effects, although the mechanism is still unclear. In this study, we determined whether propofol could antagonize methacholine-induced bronchoconstriction and determined whether vagotomy modifies this relaxant effect. Fourteen mongrel dogs anaesthetized with pentobarbital and pancuronium were assigned to a control group (n=7) and a vagotomy group (n=7). The trachea was intubated with a special endotracheal tube that had a second lumen for insertion of the bronchoscope. Bronchial cross-sectional area, which was monitored continuously through the bronchoscope, was measured with image analysis software. Bronchoconstriction was elicited with methacholine (0.5 microg kg(-1) + 5.0 microg kg(-1) min(-1)) until the end of the experiment. Thirty minutes after the start of methacholine infusion, propofol 0, 0.2, 2.0 and 20 mg kg(-1) was administered. Changes in bronchial cross-sectional area were expressed as percentages of the basal area. Plasma concentrations of propofol and catecholamine were measured by high-performance liquid chromatography. Maximal inhibition (bronchoconstriction = 0%, baseline = 100%) and IC50 (concentration producing 50% inhibition of maximal effect) produced by propofol was obtained from each concentration-response curve using a curve-fitting program. Methacholine decreased bronchial cross-sectional area to 49.3% (95% confidence interval 38.5-60.1%) and 45.3% (34.8-55.7%) of the baseline value. Propofol 20 mg kg(-1) significantly reversed this effect: bronchial cross-sectional area was reduced to 77.8% (66.2-89.6%) and 75.9% (64.0-87.9) in the control and vagotomy groups respectively. The two groups did not differ significantly in the maximal inhibitory effect of propofol [control group, 61.1% (46.3-75.9%), vagotomy group, 64.2% (40.1-88.3%)] or pIC50 [control group 5.03 (4.55-5.51), vagotomy group 4.86 (4.49-5.24)]. Therefore, the relaxant effects of propofol on methacholine-induced bronchoconstriction may not be mediated centrally. Propofol may relax airway smooth muscles directly or through the peripheral vagal pathway.

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Effect of phenylephrine on histamine-induced bronchoconstriction in dogs

Abstract: The dose of phenylephrine that produced vasopressive actions worsened the histamine-induced bronchoconstriction slightly but significantly. Therefore, phenylephrine should be used with caution in asthmatic patients.

Cited by 5 publications

References 17 publications

Spasmolytic effect of magnesium sulfate on serotonin‐induced pulmonary hypertension and bronchoconstriction in dogs

Spasmolytic effect of magnesium sulfate on serotonin‐induced pulmonary hypertension and bronchoconstriction in dogs

Study on airway smooth muscle tone using fiberoptic bronchoscopy: basic research and clinical application

Comparison of relaxant effects of propofol on methacholine-induced bronchoconstriction in dogs with and without vagotomy

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