Effect of phenolic acids and related compounds on gastric acid secretion in the rat.

Tani, Satoru

doi:10.1248/cpb.26.309

Cited by 5 publications

(3 citation statements)

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“…Tannic acid, which is classified into a group of hydrolyzable tannins, clearly suppressed gastric secretion and total acidity (15). These results suggest that effects of tannins on gastric secretion are different between condensed tannin related compounds and hydrolyzable tannins.…”

Section: Discussionmentioning

confidence: 82%

Pharmacological Studies onLinderae umbellataeRamus, IV*. Effects of Condensed Tannin Related Compounds on Peptic Activity and Stress-Induced Gastric Lesions in Mice

Ezaki¹,

Kato²,

Takizawa³

et al. 1985

Planta Med

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Nine condensed tannin related compounds isolated from LINDERAE UMBELLATAE Ramus, (+)-catechin ( 1), (-)-epicatechin ( 2), proanthocyanidin B-1 ( 3), B-2 ( 4), B-4 ( 5), trimer A ( 6), trimer B ( 7), cinnamtannin B (1) ( 8) and cinnamtannin D (1) ( 9), were tested for their effects on peptic activity and stress-induced gastric lesions in mice. Peptic activity of rat gastric juice was suppressed by 6 and 7 IN VITRO, and slightly suppressed by 8 and 9. In pylorus-ligated mice, these compounds, except for 4, administered orally exhibited anti-peptic activity. Pretreatments of 4,6 and 7 orally protected mice against stress-induced gastric lesions. Effects of these compounds on digestive systems were dìscussed.

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Section: Discussionmentioning

confidence: 82%

Pharmacological Studies onLinderae umbellataeRamus, IV*. Effects of Condensed Tannin Related Compounds on Peptic Activity and Stress-Induced Gastric Lesions in Mice

Ezaki¹,

Kato²,

Takizawa³

et al. 1985

Planta Med

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“…Tannins have astrinction actions, to be able to precipitate proteins of mucosal membranes and skin, and have a hemostatic local action (Costa, 1975). According to Tani (1976Tani ( , 1978 and Esaki et al (1985), tannins suppress gastric secretions, and in a small dose, the astrinction, which is one of the chemical properties of tannins, has been considered mainly local action for the protection of the gastric mucosa in stress-induced gastric lesions in rats. In our experiment, the action of both extracts, when administered intraperitoneally, also prevented acute gastric mucosal injury produced by stressinduced lesions (unpublished observation), revealing not tannins alone may be responsible for the antiulcer activity.…”

Section: Discussionmentioning

confidence: 99%

Antiulcer Activity of the Crude Extract from the Leaves of Casearia Sylvestris

Sertié

Carvalho

Panizza

2000

Pharmaceutical Biology

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In rats, administration of Casearia sylvestris extract derived from fresh and dried leaves protects stomach mucosa without changing gastric pH. In stress-induced acute lesions, the preventive effect of extract from dried leaves is more effective than extract from fresh leaves. In acetic acid-induced chronic ulcer, both extracts reduce the size of ulceration and increase the number of collagen fibers after 5 days of treatment, and these effects are similar with both extracts. These antiulcer activities of Casearia sylvestris may be due to the presence of volatile oils, tannins and triterpenerelated compounds.

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“…A crude extract from Linderae ramus, of which the main constituent is tannin, has been shown to be effective in various kinds of experimental ulcer models in rats (6). Tannic acid inhibits gastric acid secretion in pylorusligated rats and mice (7,8); it is also effective in acute and chronic experimental ulcer models (8,9). However, the mechanisms of anti-secretory and antiulcerogenic actions of tannic acid are not known.…”

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confidence: 99%

Inhibitory Effect of Tannic Acid on Gastric H⁺,K⁺-ATPase

Murakami

Muramatsu²,

Otomo³

1992

J. Nat. Prod.

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The effect of tannic acid on gastric H+,K(+)-ATPase was studied. Tannic acid dose-dependently inhibited pig gastric H+,K(+)-ATPase activity with an IC50 value of 2.9 x 10(-8) M. Tannic acid also inhibited K(+)-stimulated p-nitrophenyl phosphatase (K(+)-pNPPase) activity, which is found in gastric H+,K(+)-ATPase preparations, as well as H+,K(+)-ATPase activity, with an IC50 value of 4.1 x 10(-7) M. Kinetic studies showed that the inhibition of H+,K(+)-ATPase activity by tannic acid was competitive with respect to ATP and noncompetitive with respect to K+. These results show that tannic acid is a potent inhibitor of gastric H+,K(+)-ATPase; this may be related to its anti-secretory and anti-ulcerogenic effects.

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Effect of phenolic acids and related compounds on gastric acid secretion in the rat.

Cited by 5 publications

References 0 publications

Pharmacological Studies onLinderae umbellataeRamus, IV*. Effects of Condensed Tannin Related Compounds on Peptic Activity and Stress-Induced Gastric Lesions in Mice

Pharmacological Studies onLinderae umbellataeRamus, IV*. Effects of Condensed Tannin Related Compounds on Peptic Activity and Stress-Induced Gastric Lesions in Mice

Antiulcer Activity of the Crude Extract from the Leaves of Casearia Sylvestris

Inhibitory Effect of Tannic Acid on Gastric H⁺,K⁺-ATPase

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Effect of phenolic acids and related compounds on gastric acid secretion in the rat.

Cited by 5 publications

References 0 publications

Pharmacological Studies onLinderae umbellataeRamus, IV*. Effects of Condensed Tannin Related Compounds on Peptic Activity and Stress-Induced Gastric Lesions in Mice

Pharmacological Studies onLinderae umbellataeRamus, IV*. Effects of Condensed Tannin Related Compounds on Peptic Activity and Stress-Induced Gastric Lesions in Mice

Antiulcer Activity of the Crude Extract from the Leaves of Casearia Sylvestris

Inhibitory Effect of Tannic Acid on Gastric H+,K+-ATPase

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Inhibitory Effect of Tannic Acid on Gastric H⁺,K⁺-ATPase