Effect of pharmacological doses of ascorbic acid on the hepatic microsomal haemoproteins in the guinea-pig

Sutton, Judith L.; Basu, Tapan K.; Dickerson, J. W. T.

doi:10.1079/bjn19830007

Cited by 7 publications

(4 citation statements)

References 29 publications

(2 reference statements)

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“…No change in blood parameters including serum albumin, globulin, albumin/globulin ratio, total bilirubin, alkaline phosphatase, alanine aminotransferase, aspartate aminotransperase, r-glutamyltransferase and lactate dehydrogenase contents suggests that feeding dry or fermented diets did not cause any abnormal liver functions in the rats. Serum uric acid levels in humans can be affected by dietary factors such as Zn (Umeki et al, 1986) and ascorbic acid (Sutton et al, 1983). In a study with rats increased levels of serum uric acid was shown to be associated with high blood pressure and renal disease (Mazzali et al, 2001).…”

Section: Blood Parametersmentioning

confidence: 99%

Effects of Feeding a Dry or Fermented Restaurant Food Residue Mixture on Performance and Blood Profiles of Rats

Kim¹,

Bae²,

Jee³

et al. 2011

Asian Australas. J. Anim. Sci

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This study was conducted to compare the effects of feeding dry or fermented (aerobically or anaerobically with or without lactic acid bacteria) restaurant food residue mixture-containing diets on animal performance and blood profiles. Rats were used as the model animal for the simulation of laboratory rodents, rabbit or horse feeding and fed for 4 wks. The results were compared with feeding a dry diet (control) with the same ingredient composition as diets processed by aerobic and anaerobic methods. Feeding all the fermented diets tended to increase (p>0.05) average daily gain of rats resulting in improved (p<0.01) feed efficiency. Apparent digestibility of NDF was increased (p<0.05) by feeding the fermented diets, although digestibilities of DM, OM, CP, and NFC were not affected (p>0.05). Compared with the aerobically fermented diet, digestibility of ADF was increased (p<0.05) for the anaerobically fermented diet and for the 0.5% LAB culture plus anaerobically fermented diet. The digestibility of crude ash tended to increase (p>0.05) with feeding of the fermented diets. Feeding either of the fermented diets had little effects on serum nutrients, electrolytes, enzymes and blood cell profiles of rats except sodium and uric acid concentrations. These results showed that compared with feeding a dry food residue-containing diet, feeding aerobically or anaerobically fermented diets showed better animal performance as indicated by higher feed efficiency and rat growth rate. These improvements were attributed to the desirable dietary protein conservation during the food residue fermentation process and to higher total tract digestibilities of NDF and crude ash in the fermented food residue diets.

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Section: Blood Parametersmentioning

confidence: 99%

Effects of Feeding a Dry or Fermented Restaurant Food Residue Mixture on Performance and Blood Profiles of Rats

Kim¹,

Bae²,

Jee³

et al. 2011

Asian Australas. J. Anim. Sci

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“…Reports suggest antioxidant supplements, including vitamin C and E, reduce both oxidative stress and serum uric acid levels [ 56 ]. Choi et al reported that taking 1.5 g of vitamin C daily is associated with a 45% reduced incidence of gout [ 57 ]; consuming 3.0 g/day resulted in transient increases in uric acid excretion in one study [ 58 ] and a 102% increase in uricosuria in another [ 59 ]. These findings that vitamin C promotes uricosuria have led to speculation that uric acid and vitamin C compete with each other for reabsorption [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

Antioxidative effects of molybdenum and its association with reduced prevalence of hyperuricemia in the adult population

Joun,

Li,

et al. 2024

PLoS ONE

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The relationship between molybdenum and kidney-related disease outcomes, including hyperuricemia, is not well investigated. This study aims to determine whether molybdenum and its antioxidative property are associated with systemic inflammation and kidney-related disease parameters including hyperuricemia. Urinary molybdenum’s epidemiological relationship to hyperuricemia and kidney-disease related outcomes was evaluated in 15,370 adult participants in the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2016. Individuals’ urinary molybdenum levels were corrected to their urinary creatinine concentrations. The association between urinary molybdenum-to-creatinine ratio and kidney-disease related outcomes were assessed by multivariable linear and logistic regression analyses, adjusting for covariates including age, sex, ethnicity, diabetes mellitus, hypertension, body mass index, and estimated glomerular filtration rate. Antimony and tungsten were used as control trace metals. Experimentally, HK-2 cell was used to assess molybdenum’s antioxidative properties. HK-2 cells were challenged with H2O2-induced oxidative stress. Oxidative stress was measured using a fluorescent microplate assay for reactive oxygen species (ROS) and antioxidation levels were assessed by measuring the expression of manganese superoxide dismutase. In the adult NHANES population, urinary molybdenum-to-creatinine ratio was significantly associated with decreased serum uric acid (β, -0.119; 95% CI, -0.148 to -0.090) concentrations, and decreased prevalence of hyperuricemia (OR, 0.73; 95% CI, 0.64–0.83) and gout (OR, 0.71; 95% CI, 0.52–0.94). Higher urinary molybdenum levels were associated with lower levels of systemic oxidative stress (gamma-glutamyltransferase levels; β, -0.052; 95% CI, -0.067 to -0.037) and inflammation (C-reactive protein levels; β, -0.184; 95% CI, -0.220 to -0.148). In HK-2 cells under H2O2-induced oxidative stress, molybdenum upregulated manganese superoxide dismutase expression and decreased oxidative stress. Urinary molybdenum levels are associated with decreased prevalence of hyperuricemia and gout in adult population. Molybdenum’s antioxidative properties might have acted as an important mechanism for the reduction of systemic inflammation, ROS, and uric acid levels.

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“…and 3) Investigation of the thiamin antagonistic effect of widely used cytotoxic agent 5-fluorouraci on malignant diseases [45][46][47]. Dr. Basu's research on various aspects of ascorbic acid is well known, in particular, his extensive reports against its Mega dose usage have been considered to be fundamental and have received much attention [39,44,[48][49][50]. Dr. Basu's recent research investigation on diabetes is another major break through in the contemporary nutritional research realm.…”

Section: Dr T K Basu's Research Profile and Our Common Research Inmentioning

confidence: 99%

Genotype X Environment Interactions and Its Impact on Use of Medicinal Plants

Acharya¹,

Basu²,

Banik³

et al. 2010

TONUTRAJ

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There is a paradigm shift from cure to prevention when it comes to human health. We want to live a healthy life and prevent sickness using substances other than pharmaceuticals. The plant-based nutraceutical products or Natural Health Products (NHPs) as they are some times referred to are the most important groups that have the potential to fit the bill. However, these products are sold without proper science based information in spite of the fact that most researchers acknowledge the need for such information. Evidence-based scientific studies to support health and nutraceutical claims related to the use of medicinal plants and their extracts have to be undertaken. It is only through critical research efforts that we can provide strong endorsements for medicinal plant use and ensure consumer confidence in the industry. Much of the research published on the medicinal value of plants does not take into account variability generated from genetic differences among plants and their interaction with the environment. Research should be directed towards properly identifying plants with known medicinal properties which have been grown in environments that are conducive to consistent production of the active agents attributed to the plants. Production of dependable medicinal plant products can only be attained if we pay close attention to these research-based principles. This article was written with main goals: 1) To discuss the above points in greater detail with examples; and 2) to highlight life time accomplishments and significant contributions of a well respected nutritionist Dr. T. K. Basu and his collaboration in development of fenugreek as a NHP. We believe that collaboration among clinical and agricultural researchers is essential to make the NHPs utilized to its potential and the plants (parts such as seed, foliage or roots) should be developed to the extent that they can be used directly to take advantage of the synergistic effect of the chemical constituents.

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Effect of pharmacological doses of ascorbic acid on the hepatic microsomal haemoproteins in the guinea-pig

Cited by 7 publications

References 29 publications

Effects of Feeding a Dry or Fermented Restaurant Food Residue Mixture on Performance and Blood Profiles of Rats

Effects of Feeding a Dry or Fermented Restaurant Food Residue Mixture on Performance and Blood Profiles of Rats

Antioxidative effects of molybdenum and its association with reduced prevalence of hyperuricemia in the adult population

Genotype X Environment Interactions and Its Impact on Use of Medicinal Plants

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