Effect of pH on the in vitro corrosion rate of magnesium degradable implant material

Ng, Wf F.; Chiu, K. Y.; Cheng, F. T.

doi:10.1016/j.msec.2010.04.003

Cited by 121 publications

(75 citation statements)

References 33 publications

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“…The general solution of Equation (4) is the sum of homogeneous solution in Equation (12) and a particular solution,…”

Section: Single-layer Reactive Diffusionmentioning

confidence: 99%

An Analytical Model of Reactive Diffusion for Transient Electronics

Cheng²,

et al. 2013

Adv Funct Materials

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Transient electronics is a class of technology that involves components which physically disappear, in whole or in part, at prescribed rates and at programmed times. Enabled devices include medical monitors that fully resorb when implanted into the human body (“bio‐resorbable”) to avoid long‐term adverse effects, or environmental monitors that dissolve when exposed to water (“eco‐resorbable”) to eliminate the need for collection and recovery. Analytical models for dissolution of the constituent materials represent important design tools for transient electronic systems that are configured to disappear in water or biofluids. Here, solutions for reactive‐diffusion are presented in single‐ and double‐layered structures, in which the remaining thicknesses and electrical resistances are obtained analytically. The dissolution time and rate are defined in terms of the reaction constants and diffusivities of the materials, the thicknesses of the layer, and other properties of materials and solution. These models agree well with the experiments for single layers of Mg and SiO2, and double layers of Mg/MgO. The underlying physical constants extracted from analysis fall within a broad range previously reported in other studies; these constants can be extremely sensitive to the morphologies of the materials, temperature, and the PH value, concentration, and properties of the surrounding liquid.

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“…The general solution of Equation (4) is the sum of homogeneous solution in Equation (12) and a particular solution,…”

Section: Single-layer Reactive Diffusionmentioning

confidence: 99%

An Analytical Model of Reactive Diffusion for Transient Electronics

Cheng²,

et al. 2013

Adv Funct Materials

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“…Mainly due to higher chloride concentrations, HBSSs are more aggressive medium compared to artificial plasma. Sulfate ions contained in HBSS can also result in higher corrosion rate of magnesium and its alloys compared to other corrosion media used for material corrosion properties characterization [22][23][24][25][26][27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

“…Corrosion behavior of magnesium alloys was studied in several types of HBSS [22][23][24][25][26][27][28][29][30][31][32], however, the influence of the chemical composition of HBSS on corrosion processes is not available in the literature according to the authors' knowledge.…”

Section: Introductionmentioning

confidence: 99%

Influence of the Composition of the Hank’s Balanced Salt Solution on the Corrosion Behavior of AZ31 and AZ61 Magnesium Alloys

Tkácz

Doležal

Drábiková

et al. 2017

Metals

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Abstract:The electrochemical corrosion characteristics of AZ31 and AZ61 magnesium alloys were analyzed in terms of potentiodynamic tests and electrochemical impedance spectroscopy. The influence of the solution composition and material surface finish was examined also through the analysis of corrosion products created on the samples' surface after electrochemical measurements in terms of scanning electron microscopy using energy-dispersive spectroscopy. Obtained data revealed the differences in the response of the magnesium alloys to enriched Hank's Balanced Salt Solution-HBSS+ (with Mg 2+ and Ca 2+ ions) and Hank's Balanced Salt Solution-HBSS (without Mg 2+ and Ca 2+ ions). Both examined alloys exhibited better corrosion resistance from the thermodynamic and kinetic point of view in the enriched HBSS+. AZ61 magnesium alloy reached higher values of polarization resistance than AZ31 magnesium alloy in both the used corrosion solutions. Phosphate-based corrosion products were characteristic for the AZ31 and AZ61 alloys tested in the HBSS (without Mg 2+ and Ca 2+ ions). The combination of phosphate-based corrosion products and clusters of MgO and Mg(OH) 2 was typical for the surface of samples tested in the enriched HBSS+ (with Mg 2+ and Ca 2+ ions). Pitting corrosion attack was observed only in the case of enriched HBSS+.

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“…Increased solution pH has been found to cause a moderate to substantial decrease in the biocorrosion of Mg alloys [36,106]. The solubility of the corrosion layer decreases with increasing pH, and at elevated pH values Mg(OH) 2 is able to provide increasing protectiveness to the samples' surface, lowering the rate of biocorrosion.…”

Section: Ph and Buffer Systemsmentioning

confidence: 99%

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

2017

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The factors that influence magnesium (Mg) corrosion in vitro are systematically evaluated from a review of the relevant literature. We analysed the influence of the following factors on Mg biocorrosion in vitro: (i) inorganic ions, including both anions and cations, (ii) organic components such as proteins, amino acids and vitamins, and (iii) experimental parameters such as temperature, pH, buffer system and flow rate. Considerations and recommendations towards a standardised approach to in vitro biocorrosion testing are given. Several potential simulated body fluids are recommended. Implementing a standardised approach to experimental parameters has the potential to significantly reduce variability between in vitro biocorrosion tests, and to help build towards a methodology that accurately and consistently mimics in vivo corrosion. However, there are also knowledge gaps with regard to how best to characterise the in vivo environment and corrosion mechanism. The assumption that blood plasma is the correct bodily fluid upon which to base in vitro methodologies is examined, and factors that influence the corrosion mechanism in vivo, such as specimen encapsulation, bear consideration for further studies.

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Effect of pH on the in vitro corrosion rate of magnesium degradable implant material

Cited by 121 publications

References 33 publications

An Analytical Model of Reactive Diffusion for Transient Electronics

An Analytical Model of Reactive Diffusion for Transient Electronics

Influence of the Composition of the Hank’s Balanced Salt Solution on the Corrosion Behavior of AZ31 and AZ61 Magnesium Alloys

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

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