Effect of pH on the toxicity and bioconcentration of sulfadiazine on Daphnia magna

Anskjær, Gitte Gotholdt; Rendal, Cecilie; Kusk, Kresten Ole

doi:10.1016/j.chemosphere.2013.01.029

Cited by 42 publications

(15 citation statements)

References 31 publications

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“…In addition, several controlled laboratory studies have been addressed to investigate sulfonamides bioaccumulation in water ecosystems. Anskjaer et al (2013) observed that the uptake of sulfadiazine in Daphnia magna was significantly influenced by pH and higher bioconcentration was found at lower pH levels. Migliore et al (1993) found that sulfadimethoxine tended to accumulate in brine shrimp Artemia, and could significantly reduce the hatching rate.…”

Section: Introductionmentioning

confidence: 94%

“…Nevertheless, to estimate BCF for ionizing compounds (e.g., sulfonamides) is difficult due to the difference in lipophilicity of neutral and ionized species. It has been demonstrated that the neutral fraction is not solely responsible for sulfonamides bioconcentration in aquatic organisms (Lo and Hayton, 1981;Anskjaer et al, 2013). Meylan et al (1999) developed an improved screening-level BCF estimation method (r 2 = 0.73, ME = 0.48) and proposed that log BCF values were 0.5 for the ionizable compounds with log K ow < 5.…”

Section: Bioconcentration Factors Of Two Sulfonamidesmentioning

confidence: 99%

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Biological uptake and depuration of sulfadiazine and sulfamethoxazole in common carp (Cyprinus carpio)

et al. 2015

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Section: Introductionmentioning

confidence: 94%

Section: Bioconcentration Factors Of Two Sulfonamidesmentioning

confidence: 99%

Biological uptake and depuration of sulfadiazine and sulfamethoxazole in common carp (Cyprinus carpio)

et al. 2015

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“…The categories of chemicals that have a greater tendency to be ionizable include pharmaceuticals and some classes of pesticides12. The dependence on pH of the toxicity and bioconcentration of ionizable organic compounds to organisms has been observed in many studies3456. This dependence greatly influences the estimation of the toxicity and bioconcentration of ionizable organic compounds because the pH of natural waters fluctuates from 6 to 97.…”

mentioning

confidence: 99%

“…1). Anskjær, et al 5. reported that the toxicity and bioconcentration of sulfadiazine in Daphnia magna depend on the pH.…”

mentioning

confidence: 99%

Estimation of the toxicity of sulfadiazine to Daphnia magna using negligible depletion hollow-fiber liquid-phase microextraction independent of ambient pH

Liu

Zhang

et al. 2016

Sci Rep

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The toxicity of ionizable organic compounds to organisms depends on the pH, which therefore affects risk assessments of these compounds. However, there is not a direct chemical method to predict the toxicity of ionizable organic compounds. To determine whether hollow-fiber liquid-phase microextraction (HF-LPME) is applicable for this purpose, a three-phase HF-LPME was used to measure sulfadiazine and estimate its toxicity to Daphnia magna in solutions of different pH. The result indicated that the sulfadiazine concentrations measured by HF-LPME decreased with increasing pH, which is consistent with the decreased toxicity. The concentration immobilize 50% of the daphnids (EC50) in 48 h calculated from nominal concentrations increased from 11.93 to 273.5 mg L−1 as the pH increased from 6.0 to 8.5, and the coefficient of variation (CV) of the EC50 values reached 104.6%. When calculated from the concentrations measured by HF-LPME (pH 12 acceptor phase), the EC50 ranged from 223.4 to 394.6 mg L−1, and the CV decreased to 27.60%, suggesting that the concentrations measured by HF-LPME can be used to estimate the toxicity of sulfadiazine irrespective of the solution pH.

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“…Direct relationships between the low levels of pharmaceuticals identified in drinking water and adverse impacts to human health are not being observed at this time [46,47]. However, numerous laboratory studies [48][49][50][51][52][53][54][55][56] and literature reviews [57][58][59] have demonstrated the negative impacts of drugs to aquatic organisms.…”

Section: Introductionmentioning

confidence: 99%

Pharmaceutical Dispensing and Wasting In Health Care Facilities, Amounts, Costs and Evaluation of Potential Ecologic Effects

Mankes¹,

Silver²

2017

SOJPPS

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Drug waste from hospitals contributes to environmental contamination. Patient excreta, bathing or discarding of excess drugs are some sources of drug waste. We report on the wasting of 84 drugs of 14 therapeutic classes in two hospitals in Albany, NY. We consider drug metabolism, excretion, disposal and ecotoxicity in strategies for reducing drug waste, costs and potential environmental damage.Medication (12,345) and waste collection (199) records for: drugs dispensed, returned and wasted were examined. Of 2,700 drugs available, 84 drugs from 14 classes, weighing 56 kg were dispensed to patients, and 2.3 kg were wasted. Twelve drugs accounted for 80 percent of the drug waste and cost $111,000. Of the top wasted and dispensed drugs, all but ibuprofen are persistant and none were bioaccumulative. Ibuprofen, ipratropium ondansetron and oxymetazoline are "very highly toxic" or "highly toxic". Environmental Risk Ratio (PEC/PNEC) for the 20 top drugs were"Insignificant" or "Cannot Be Excluded".Acetazolamide is the most toxic to fish. Dexamethasone has the greatest chronic toxicity to Ceriodaphnia. Ibuprofen is predicted to be very highly toxic (acute and chronic) to zebra mussel, crab and fish. Neostigmine is the most acutely toxic (LC50<1 mg/L) to Daphnia. Ondansetron is the most acutely toxic to green algae. All but 2 of the drugs were 5 to 100% excreted. Fourteen were metabolised. Active metabolites were formed from 2 drugs. Nicardipine, ondansetron and prednisone formed drug conjugates which were excreted. Incineration was the manufacturer's recommended disposal method.We recommend excess drugs be returned to the hospital pharmacy for disposal by incineration. Drug use and disposal should be monitored by an expert committee according to recognized guidelines of pharmaceutical management. Knowledge of the adverse impacts from the release of highly toxic drugs into the environment must influence drug selection and disposal.Key words: Waste; Ecotoxicity; Wastewater; Abbreviations AMCH = Academic Medical Center Hospital; ASTER = Assessment Tools for the Evaluation of Risk. United States Environmental Protection Agency https://archive.epa.gov/med/med_archive_03/web/html/ aster.html Last accessed 6/4/17; B = Bioaccumulation is the general term describing a process by which chemicals are taken up by an organism either directly from exposure to a contaminated medium or by consumption of food containing the chemical; EC50 = Effective Concentration producing an adverse effect in 50% of a test species; EbC50 or ErC50 = EC50 in terms of reduction of growth rate; EyC50 = EC50 in terms of change in biomass yield; Ecosar = Ecologic Structure Activity Relationships is a computerized predictive system that estimates aquatic toxicity. The program estimates a chemical's acute (short-term) toxicity and chronic (long-term or delayed) toxicity to aquatic organisms such as fish, invertebrates, and plants by using computerized Structure Activity Relationships (SARs). https://www.epa.gov/tsca-screening-tools/ ecological-structure-...

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Effect of pH on the toxicity and bioconcentration of sulfadiazine on Daphnia magna

Cited by 42 publications

References 31 publications

Biological uptake and depuration of sulfadiazine and sulfamethoxazole in common carp (Cyprinus carpio)

Biological uptake and depuration of sulfadiazine and sulfamethoxazole in common carp (Cyprinus carpio)

Estimation of the toxicity of sulfadiazine to Daphnia magna using negligible depletion hollow-fiber liquid-phase microextraction independent of ambient pH

Pharmaceutical Dispensing and Wasting In Health Care Facilities, Amounts, Costs and Evaluation of Potential Ecologic Effects

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