Effect of pH and β-cyclodextrin on the photophysical properties of lamotrigine

Abstract

Abstract:Photophysical properties of lamotrigine (LMT) were investigated at different pH values. Lamotrigine exhibited a broad absorption band at 308 nm that was shifted to 268 nm at pH 2.0 due to protonation (HLMT +) . Emission spectra of LMT at different pH values showed a single band at 483 nm except for at pH 2.0, where a second band at 502 nm was observed due to the deprotonation from the singlet excited state. LMT pH profile was used to calculate that LMT is preferentially included within the β -CD cavity through its diamino-1,2,4-triazine moiety.

Investigation of Solvent Effect and H-Bonding on Spectroscopic Properties of 1-(3-Amino-6-(2,5-dichlorothiophen-3-yl)-4-phenylfuro[2,3-b]Pyridin-2-yl) Ethenone: Experimental and Computational Study

“…Solutions of pH profiles were aqueous 0.1 mol L −1 phosphate buffer solutions within the pH range of 1-13. All fluorescence measurements were made according to previously described method [10].…”