Effect of pH and nonionic surfactant on profile of intracellular and extracellular Monascus pigments

Kang, Bor‐Hwang; Zhang, Xuehong; Wu, Zhenqiang; Qi, Haifeng; Wang, Zhilong

doi:10.1016/j.procbio.2013.03.020

Cited by 68 publications

(42 citation statements)

References 33 publications

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“…The concentration of Monascus pigments is usually represented by the absorbance at their characteristic wavelength (Babitha et al 2007). However, there is overlap among the absorbance spectrum of single component in Monascus pigments (Zheng et al 2009) and the composition of Monascus pigments is always changed with the various culture conditions (Kang et al 2013a), which makes the representation of pigment concentration by color value inaccurate. Thus, the visible spectrum of Monascus pigments was determined.…”

Section: Discussionmentioning

confidence: 99%

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Accumulation of yellow Monascus pigments by extractive fermentation in nonionic surfactant micelle aqueous solution

Zhang

et al. 2014

Appl Microbiol Biotechnol

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Monascus species can produce various secondary metabolites of polyketide structure. In the current study, it is found that an interesting phenomenon, i.e., submerged culture of Monascus species in an aqueous solution majorly accumulated intracellular orange Monascus pigments exhibiting one peak at 470 nm with absorbance of 32 OD while extractive fermentation in a nonionic surfactant micelle aqueous solution produced extracellular and intracellular yellow Monascus pigments exhibiting one peak at 410 nm with absorbance 30 OD and 12 OD, respectively. The spectrum profiles of both intracellular and extracellular Monascus pigments were affected by surfactant loading, extractive fermentation time, and surfactant adding time. Meanwhile, the instability of orange Monascus pigments in the extracellular nonionic surfactant micelle aqueous solution was also confirmed experimentally. The mechanism behind this phenomenon is attributed to the export of intracellular yellow Monascus pigments into its broth by extractive fermentation. The transferring of intracellular yellow Monascus pigments into its broth blocks yellow Monascus pigments from further enzymatic conversion or eliminates the feedback inhibition of yellow Monascus pigments based on the biosynthetic pathway of Monascus pigments.

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Section: Discussionmentioning

confidence: 99%

“…It was observed that the profile of Monascus pigments was affected by both pH of the culture medium and extractive fermentation (Kang et al 2013a). Our interest spurs us to study the effect of nonionic surfactant on the composition of Monascus pigments and then search for the mechanism behind this phenomenon.…”

Section: Introductionmentioning

confidence: 99%

Accumulation of yellow Monascus pigments by extractive fermentation in nonionic surfactant micelle aqueous solution

Zhang

et al. 2014

Appl Microbiol Biotechnol

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“…1) in Triton X-100 micelle aqueous solution was conducted following in a similar procedure to our previous work [10]. M. anka (China Center of Industrial Culture Collection, CICC 5013) was maintained on potato dextrose agar (PDA) medium (potato 200 g, glucose 20 g and agar 15-20 g, per liter of tap water) at 4°C.…”

Section: Extractive Fermentation Of Monascus Pigmentsmentioning

confidence: 99%

“…The hydrophobic Monascus pigments are majorly accumulated intracellularly in conventional submerged aqueous culture. Recently, nonionic surfactant micelle aqueous solution is further developed for extractive fermentation of intracellular Monascus pigments [9], in which secretion of intracellular product and regulation of secondary microbial metabolites are fulfilled at the same time [10,11]. Especially, extractive fermentation in the nonionic surfactant Triton X-100 micelle aqueous solution with high MSG (monosodium glutamate) concentration produces the high color hue of red Monascus pigment derivates with MSG (monosodium glutamate) residue (Fig.…”

Section: Introductionmentioning

confidence: 99%

Transferring of red Monascus pigments from nonionic surfactant to hydrophobic ionic liquid by novel microemulsion extraction

Shen

Zhang

Liu

et al. 2014

Separation and Purification Technology

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“…Micelle aqueous solution, from addition of nonionic surfactant (Triton X-100) into the fermentation broth, facilitates intracellular conversion of MOPs to MYPs. MYPs are simultaneously extracted from the mycelia and effectively secreted into the broth (Kang et al 2013;Xiong et al 2015). These new techniques require more investigation and development before application at commercial scales.…”

Section: New Methods In Fermentationmentioning

confidence: 99%

Production and biological activities of yellow pigments from Monascus fungi

Chen

2016

World J Microbiol Biotechnol

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Monascus yellow pigments (MYPs), are azaphilone compounds and one of the three main components of total Monascus pigments (MPs). Thirty-five hydrophilic or hydrophobic MYPs have been identified, with the majority being hydrophobic. Apart from screening special Monascus strains, some advanced approaches, such as extractive and high-cell-density fermentations, have been applied for developing or producing new MYPs, especially extracellular hydrophilic MYPs. The outstanding performance of MYPs in terms of resistance to photodegradation, as well as tolerance for temperature and pH, give natural MYPs reasonable prospects, compared with the orange and red MPs, for practical use in the present and future. Meanwhile, MYPs have shown promising potential for applications in the food and pharmaceutical industries based on their described bioactivities. This review briefly summarizes the reports to date on chemical structures, biological activities, biosynthetic pathways, production technologies, and physicochemical performances of MYPs. The existing problems for MYPs are discussed and research prospects proposed.

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Effect of pH and nonionic surfactant on profile of intracellular and extracellular Monascus pigments

Cited by 68 publications

References 33 publications

Accumulation of yellow Monascus pigments by extractive fermentation in nonionic surfactant micelle aqueous solution

Accumulation of yellow Monascus pigments by extractive fermentation in nonionic surfactant micelle aqueous solution

Transferring of red Monascus pigments from nonionic surfactant to hydrophobic ionic liquid by novel microemulsion extraction

Production and biological activities of yellow pigments from Monascus fungi

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