Effect of PGF2α and Methylergometrine during Puerperium in Gir Cows

Abstract

The therapeutic efficacy of methylergometrine and PGF2α on uterine involution and postpartum fertility was studied in 18 (6/group) Gir cows. Animals of groups I and II were treated with single i/m injection of PGF2α and Methylergometrine immediately after parturition, respectively, while group-III served as untreated control. The time required for expulsion of fetal membranes was shorter in group-I (2.55 ± 0.60 hours) than in group II (3.03 ± 0.34 hours) and group III (4.10 ± 0.36 hours) but did not differ statistically. Time taken for completion of uterine involution was significantly (p Less than 0.05) shorter in group I (28.67±1.12 days) than that of group II (35.83 ± 1.49 days) and group-III (41.00±1.46 days). The intervals for first estrus postpartum and service period were also significantly (p Less than 0.01) shorter for group I (37.83 ± 1.10 and 89.50 ± 4.34 days) than in group-II (46.17 ± 1.40 and 108.33 ± 4.91 days) and group-III (50.83 ± 1.11 and 118.33 ± 4.40 days, respectively). The number of services per conception was non-significantly lower in group I (1.17 ± 0.17) as compared to group II (1.50 ± 0.34) and controlled group III (1.67±0.33). The conception rate was 100% in group I and 83.33 % each in group II and III. Thus, it can be concluded that use of PGF2α immediately after parturition in Gir cows enhanced the process of placental separation, hastened the uterine involution, decreased the service period, increased the conception rate and thereby reduce the calving interval to the profitable ambiance as compared to Methylergometrine and control groups.

Prevention of Retention of Placenta in Lactating Friesian Cows with Dystocia and its Relation with their Productive and Reproductive Efficiency and Blood Constituents

“…In same trend was observed with (Khatri et al 2013;Hanan, 2015 andAbou-Aiana et al, 2019) who demonstrated that time required from calving to complete uterine involution was significantly shorter in PGF2αtreated cows than that recorded for either oxytocin-treated and control cows. Also, (Solanki et al, 2019) found that administration of methylergometrine or PGF2α immediately after parturition in Gir cows hastened (P<0.05) the uterine involution. Rapid and earlier fetal membranes drop and uterine involution after administration of PG or MT may be due to immunepotentiating effect of prostaglandin F2 alpha or methylergometrine maleate.…”

“…Our findings were supported by (Abou-Aiana et al, 2019), who demonstrated that there were decrease in the time from parturition till the first estrus postpartum and days open in cows administrated with PGF2α or oxytocin intramuscularly injection as compared to that in the control cows. Also, (Solanki et al, 2019) found that administration of methylergometrine or PGF2α immediately after parturition in Gir cows reduced postpartum estrus and service period. In contrary, (Hendricks et al 2006 andHanan, 2015) who indicated that repeated administration of PGF2α to cows following postcalving had no impact on interval from calving to first service or days open.…”

“…Time elapsed from parturition to complete fetal membranes drop was shorter in cows received oxytocin or methylergometrine maleate/ intramuscularly injection than in untreated cows (Azad et al, 2016 andMadhwal et al, 2019). Also, the usage of methylergometrine or PGF2α immediately postpartum reduced (P<0.05) the incidence of retained fetal membranes and improved reproductive performance in cows Metwally, 2004 andSolanki et al, 2019). Additionally, administration of 500 μg PGF2α or 50 I.U.…”

“…There are many factors influencing the incidence of retained fetal membranes like abortion, dystocia, multiple birth, poor body condition scores, age, nutritional deficiencies, and hormonal imbalance (Grunert, 1986). Abnormal parturition or puerperal complications leads to retention of placenta and its negative sequel on reproductive performance of cows (Ahmed et al, 2004;Kumari et al, 2014 andSolanki et al, 2019), further associated with enhanced risk for endometritis and metritis (Mc Dougall, 2001). High levels of prostaglandin F2α or PG E2 are released from the uterus during the early postcalving time in cows, may play an important role in both placental separation and uterine involution (Slama et al 1994).…”

“…For the prevention or treatment of retention of placenta, injections of ecbolic drugs as oxytocin, prostaglandin F2 alpha (PGF2α) or methylergometrine have been administrated within 24 hours of parturition (Nosier et al, 2012 andSolanki et al 2019). Time elapsed from parturition to complete fetal membranes drop was shorter in cows received oxytocin or methylergometrine maleate/ intramuscularly injection than in untreated cows (Azad et al, 2016 andMadhwal et al, 2019).…”